Cd40lg
Gene Detail

Symbol Name ID

Cd40lg CD40 ligand MGI:88337

Synonyms

CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5

Feature Type

protein coding gene

Genetic Map

Chromosome X

31.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:57212143-57224042 bp, + strand From VEGA annotation of GRCm38   11900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor ligand superfamily protein, CD40 ligand type
Gene Tree: Cd40lg

Human homologs

Human Homolog		CD40LG, CD40 ligand
NCBI Gene ID		959
neXtProt AC		NX_P29965
Human Synonyms		CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP
Human Chr (Location)		Xq26; chrX:136648177-136660390 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human CD40LG

Alleles and phenotypes

All alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from APF )
 

Nullizygous mutations affect T-dependent humoral responses, germinal center formation, isotype switching and T cell differentiation, and may alter osteoclastogenesis, thrombogenesis, and susceptibility to autoimmune diabetes and prion infection. ENU mutants fail to show an IgG response to rSFV.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	B cell differentiation, B cell proliferation, ...
Component	cell, cell surface, ...
Function	CD40 receptor binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (18)    Tissues (5)    Images (9)
Theiler Stages: 23

Assay Type	Results
RNA in situ	18

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) Genomic(2) cDNA(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017791 (Evidence)
Ensembl Gene Model	ENSMUSG00000031132 (Evidence)
Entrez Gene	21947 (Evidence)
UniGene	4861
DFCI	TC1594456
DoTS	DT.87038738
PDB	1CDA
Consensus CDS Project	CCDS30152.1
International Mouse Knockout Project Status	Cd40lg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017791	VEGA Gene Model | MGI Sequence Detail	11900	C57BL/6J
transcript	OTTMUST00000043051	VEGA | MGI Sequence Detail	1250	Not Applicable
polypeptide	OTTMUSP00000019349	VEGA | MGI Sequence Detail	260	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(87 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR003263	Tumour necrosis factor ligand 5
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000001950	tumor necrosis factor ligand superfamily member 5

References

(Earliest) J:831 Armitage RJ, et al., Molecular and biological characterization of a murine ligand for CD40. Nature. 1992 May 7;357(6373):80-2
(Latest) J:209382 Muth S, et al., A CD40/CD40L feedback loop drives the breakdown of CD8(+) T-cell tolerance following depletion of suppressive CD4(+) T cells. Eur J Immunol. 2014 Apr;44(4):1099-107
All references(281)

Other accession IDs

MGD-MRK-12004, MGD-MRK-12047, MGD-MRK-1860