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Cd40lg
Gene Detail
 Symbol
Name
ID
Cd40lg
CD40 ligand
MGI:88337
Synonyms CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5
Feature Type protein coding gene
Genetic Map
Chromosome X
31.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:57212143-57224042 bp, + strand
From VEGA annotation of GRCm38

  11900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tumor necrosis factor ligand superfamily protein, CD40 ligand type
Gene Tree: Cd40lg

Human
homologs
Human Homolog CD40LG, CD40 ligand
NCBI Gene ID 959
neXtProt AC  NX_P29965
Human Synonyms  CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP
Human Chr (Location)  Xq26; chrX:136648177-136660390 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD40LG
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from APF )
 
Nullizygous mutations affect T-dependent humoral responses, germinal center formation, isotype switching and T cell differentiation, and may alter osteoclastogenesis, thrombogenesis, and susceptibility to autoimmune diabetes and prion infection. ENU mutants fail to show an IgG response to rSFV.
 
Interactions
Cd40lg interacts with 105 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process B cell differentiation, B cell proliferation, ...
Component cell, cell surface, ...
Function CD40 receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (5)    Images (9)
Theiler Stages: 23
Assay TypeResults
RNA in situ 18
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(2) cDNA(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017791 (Evidence)
Ensembl Gene ModelENSMUSG00000031132 (Evidence)
Entrez Gene21947 (Evidence)
UniGene4861
DFCITC1594456
DoTSDT.87038738
PDB1CDA
Consensus CDS ProjectCCDS30152.1
International Mouse Knockout Project StatusCd40lg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017791 VEGA Gene Model | MGI Sequence Detail 11900 C57BL/6J ±  kb
transcript OTTMUST00000043051 VEGA | MGI Sequence Detail 1250 Not Applicable 
polypeptide OTTMUSP00000019349 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR003263 Tumour necrosis factor ligand 5
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000001950 tumor necrosis factor ligand superfamily member 5
References (Earliest) J:831 Armitage RJ, et al., Molecular and biological characterization of a murine ligand for CD40. Nature. 1992 May 7;357(6373):80-2
(Latest) J:209382 Muth S, et al., A CD40/CD40L feedback loop drives the breakdown of CD8(+) T-cell tolerance following depletion of suppressive CD4(+) T cells. Eur J Immunol. 2014 Apr;44(4):1099-107
All references(281)
Other
accession IDs
MGD-MRK-12004, MGD-MRK-12047, MGD-MRK-1860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory