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Cd40lg Gene Detail
Summary
  • Symbol
    Cd40lg
  • Name
    CD40 ligand
  • Synonyms
    CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88337
    NCBI Gene: 21947
  • Gene Overview
    MyGene.info: CD40LG
Location & Maps
more
  • Sequence Map
    ChrX:57212143-57224042 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      11900 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 31.21 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CD40LG, CD40 ligand
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD40LG, CD40 ligand
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP
  • Links
    NCBI Gene ID: 959
    neXtProt AC: NX_P29965

  • Chr Location
    Xq26; chrX:136648177-136660390 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    2 with Cd40lg mouse models; 1 with human CD40LG associations

Human Disease Mouse Models
       Immunodeficiency with Hyper-IgM, Type 1; HIGM1   OMIM: 308230 View 3 "NOT" models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    73 phenotypes from 5 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    201 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
    APF
Nullizygous mutations affect T-dependent humoral responses, germinal center formation, isotype switching and T cell differentiation, and may alter osteoclastogenesis, thrombogenesis, and susceptibility to autoimmune diabetes and prion infection. ENU mutants fail to show an IgG response to rSFV.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    18
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017791 VEGA Gene Model | MGI Sequence Detail 11900 C57BL/6J ±  kb
transcript OTTMUST00000043051 VEGA | MGI Sequence Detail 1250 Not Applicable  
polypeptide OTTMUSP00000019349 VEGA | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    87 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001950 tumor necrosis factor ligand superfamily member 5
  • PDB
    1CDA
  • InterPro Domains
    IPR003263 CD40 ligand
    IPR021184 Tumour necrosis factor, conserved site
    IPR006052 Tumour necrosis factor domain
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
less
  • All nucleic 5
    Genomic 2
    cDNA 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12004, MGD-MRK-12047, MGD-MRK-1860
References
more
  • Summaries
    All 284
    Developmental Gene Expression 2
    Diseases 4
    Gene Ontology 9
    Phenotypes 201
  • Earliest
    J:831 Armitage RJ, et al., Molecular and biological characterization of a murine ligand for CD40. Nature. 1992 May 7;357(6373):80-2
  • Latest
    J:234978 Marigo I, et al., T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell. 2016 Sep 12;30(3):377-90
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory