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Cd40lg Gene Detail
Summary
  • Symbol
    Cd40lg
  • Name
    CD40 ligand
  • Synonyms
    CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88337
    NCBI Gene: 21947
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:56257503-56269402 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 31.21 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88337
 protein coding gene ChrX:56257448-56269402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035746
 protein coding gene ChrX:52538283-52549797 (+)
A/J MGP_AJ_G0035729
 protein coding gene ChrX:52733634-52747033 (+)
AKR/J MGP_AKRJ_G0035649
 protein coding gene ChrX:54131638-54145090 (+)
BALB/cJ MGP_BALBcJ_G0035716
 protein coding gene ChrX:52181879-52193446 (+)
C3H/HeJ MGP_C3HHeJ_G0035418
 protein coding gene ChrX:53066066-53078672 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036245
 protein coding gene ChrX:53928661-53940296 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033096
 protein coding gene ChrX:52138676-52150404 (+)
CAST/EiJ MGP_CASTEiJ_G0034711
 protein coding gene ChrX:38958033-38970520 (+)
CBA/J MGP_CBAJ_G0035393
 protein coding gene ChrX:55509028-55522287 (+)
DBA/2J MGP_DBA2J_G0035547
 protein coding gene ChrX:52311470-52323416 (+)
FVB/NJ MGP_FVBNJ_G0035497
 protein coding gene ChrX:51904732-51917031 (+)
LP/J MGP_LPJ_G0035635
 protein coding gene ChrX:53121870-53133405 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035533
 protein coding gene ChrX:57058438-57069992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036261
 protein coding gene ChrX:52566520-52578069 (+)
PWK/PhJ MGP_PWKPhJ_G0034407
 protein coding gene ChrX:37228092-37239902 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034251
 protein coding gene ChrX:39709051-39722082 (+)
WSB/EiJ MGP_WSBEiJ_G0034854
 protein coding gene ChrX:52106433-52119070 (+)



Homology
more
  • Human Ortholog
    CD40LG, CD40 ligand
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD40LG, CD40 ligand
  • Synonyms
    CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP
  • Links
    NCBI Gene ID: 959
    neXtProt AC: NX_P29965
    UniProt: P29965

  • Chr Location
    Xq26.3; chrX:136648158-136660390 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cd40lg mouse models; 12 with human CD40LG associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 5 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    239 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations affect T-dependent humoral responses, germinal center formation, isotype switching and T cell differentiation, and may alter osteoclastogenesis, thrombogenesis, and susceptibility to autoimmune diabetes and prion infection. ENU mutants fail to show an IgG response to rSFV.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    13
  • cDNA Data
    4
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031132 Ensembl Gene Model | MGI Sequence Detail 11900 C57BL/6J ±  kb
    transcript ENSMUST00000033466 Ensembl | MGI Sequence Detail 1250 Not Applicable  
    polypeptide ENSMUSP00000033466 Ensembl | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 4
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12004, MGD-MRK-12047, MGD-MRK-1860
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 12
      Phenotypes 239
    • Earliest
      J:831 Armitage RJ, et al., Molecular and biological characterization of a murine ligand for CD40. Nature. 1992 May 7;357(6373):80-2
    • Latest
      J:342049 Calzada-Fraile D, et al., Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8(+) T cells. Nat Commun. 2023 Oct 25;14(1):6772
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory