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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd40lg
CD40 ligand
MGI:88337
73 phenotypes from 5 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd40lgm1Btlr/Y
involves: C57BL/6J 		abnormal class switch recombination J:185495
decreased IgG level J:185495
normal immune system phenotype J:185495
Cd40lgm1Btlr/Cd40lgm1Btlr
C57BL/6J-Cd40lgm1Btlr 		decreased IgG level J:162147
normal immune system phenotype J:162147
Cd40lgm1Btlr/Cd40lgm1Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
decreased IgG level J:185495
normal immune system phenotype J:185495
Cd40lgtm1Flv/Cd40lgtm1Flv
involves: 129S2/SvPas * C57BL/6 		abnormal adaptive immunity J:25010
abnormal class switch recombination J:25010
abnormal immune system morphology J:25010
abnormal immune system physiology J:25010
abnormal osteoclast differentiation J:120087
abnormal T cell differentiation J:25010
abnormal T-helper 2 physiology J:25010
absent spleen germinal center J:25010
decreased double-positive T cell number J:25010
decreased IgA level J:25010
decreased IgD level J:25010
decreased IgE level J:25010
decreased IgG1 level J:25010
decreased IgG3 level J:25010
decreased immunoglobulin level J:25010
increased CD4-positive, alpha-beta T cell number J:25010
Cd40lgtm1Flv/Cd40lgtm1Flv
NOD.129S2-Cd40lgtm1Flv 		decreased regulatory T cell number J:93421
decreased susceptibility to autoimmune diabetes J:93421
Cd40lgtm1Imx/Y
B6.129S2-Cd40lgtm1Imx/J 		abnormal leukocyte adhesion J:108988
abnormal thalamus morphology J:106362
decreased cerebral infarct size J:108988
decreased platelet aggregation J:108988
Cd40lgtm1Imx/?
B6.129S2-Cd40lgtm1Imx/J 		decreased bone mineral density J:145330
decreased compact bone mass J:145330
decreased trabecular bone mass J:145330
Cd40lgtm1Imx/Y
involves: 129S2/SvPas * C57BL/6 		abnormal antigen presentation J:21137
abnormal class switch recombination J:21137
abnormal immune system organ morphology J:21137
abnormal immune system physiology J:21137
abnormal lymph node morphology J:21137
absent lymph node germinal center J:21137
absent spleen germinal center J:21137
decreased IgA level J:21137
decreased IgE level J:21137
decreased IgG1 level J:21137
decreased IgG2b level J:21137
decreased immunoglobulin level J:21137
normal immune system phenotype J:21137
lymph node hypoplasia J:21137
Cd40lgtm1Imx/?
involves: 129S2/SvPas * C57BL/6 		abnormal thrombosis J:103954
abnormal vascular endothelial cell morphology J:115587
decreased platelet aggregation J:103954
normal hematopoietic system phenotype J:103954
increased bleeding time J:103954
Cd40lgtm1Imx/Cd40lgtm1Imx
involves: 129S2/SvPas * C57BL/6 		abnormal blood coagulation J:75152
abnormal nervous system physiology J:115487
increased susceptibility to prion infection J:115487
loss of cortex neurons J:115487
microgliosis J:115487
neurodegeneration J:115487
normal reproductive system phenotype J:21137
spongiform encephalopathy J:115487
Cd40lgtm1Imx/Cd40lgtm1Imx
involves: 129S2/SvPas * C57BL/6J * BALB/c 		abnormal T cell clonal deletion J:110925
Cd40lgtm1Parl/Cd40lgtm1Parl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
increased IgG1 level J:213459
thrombocytopenia J:213459
Cd40lgtm1Parl/Cd40lgtm1Parl
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
normal immune system phenotype J:213459
Cd40lgtm1Parl/Cd40lgtm1Parl
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * CD-1 * SJL 		decreased IgA level J:213459
decreased IgG1 level J:213459
decreased IgG2a level J:213459
decreased IgG3 level J:213459
decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
Cd40lgtm1Parl/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
increased IgG1 level J:213459
thrombocytopenia J:213459
Cd40lgtm1Parl/Y
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
normal immune system phenotype J:213459
Cd40lgtm1Parl/Y
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * CD-1 * SJL 		decreased IgA level J:213459
decreased IgG1 level J:213459
decreased IgG2a level J:213459
decreased IgG3 level J:213459
decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
Tg(Igh-V-CD40lg)#Tsub/0
C57BL/6-Tg(Igh-V-CD40lg)#Tsub 		glomerulonephritis J:128824
increased anti-double stranded DNA antibody level J:128824
increased anti-histone antibody level J:128824
increased anti-single stranded DNA antibody level J:128824
increased urine protein level J:128824
Tg(Igh-V-CD40lg)#Tsub/0
involves: C57BL/6 		abnormal bronchus-associated lymphoid tissue morphology J:89855
abnormal colon goblet cell morphology J:89855
abnormal colon morphology J:89855
abnormal ileum crypts of Lieberkuhn morphology J:89855
abnormal intestinal mucosa morphology J:89855
colitis J:89855
diarrhea J:89855
enlarged lymph nodes J:89855
enlarged spleen J:89855
glomerulonephritis J:89855
increased autoantibody level J:89855
increased IgG level J:89855
increased IgM level J:89855
increased interferon-gamma secretion J:89855
increased splenocyte number J:89855
increased splenocyte proliferation J:89855
megacolon J:89855
weight loss J:89855
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04/30/2024
MGI 6.23 		The Jackson Laboratory