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Cd40
Gene Detail
 Symbol
Name
ID
Cd40
CD40 antigen
MGI:88336
Synonyms Bp50, Cd40, p50, Tnfrsf5
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr2:165055627-165072948 bp, + strand
From VEGA annotation of GRCm38

  17322 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor receptor superfamily member 5
Gene Tree: Cd40

Human
homologs
Human Homolog CD40, CD40 molecule, TNF receptor superfamily member 5
NCBI Gene ID 958
neXtProt AC  NX_P25942
Human Synonyms  Bp50, CDW40, p50, TNFRSF5
Human Chr (Location)  20q12-q13.2; chr20:46118260-46129745 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD40
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Gene trapped(1)
 
Homozygous inactivation of this gene may cause impaired immunoglobulin class switching and germinal center formation, reduced susceptibility to type II hypersensitivity reaction, impaired priming of T cells and control of M. tuberculosis infection, and altered response to transplant.
 
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process B cell activation, cellular calcium ion homeostasis, ...
Component CD40 receptor complex, cell surface, ...
Function antigen binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(10) cDNA(24) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016424 (Evidence)
Ensembl Gene ModelENSMUSG00000017652 (Evidence)
Entrez Gene21939 (Evidence)
UniGene271833
DFCITC1575459, TC1593855, TC1682219, TC1772398
DoTSDT.101194552, DT.110729823, DT.91339881, DT.99863551, DT.99863552, DT.99863553
NIA Mouse Gene IndexU002826
Consensus CDS ProjectCCDS17069.1, CCDS17070.1, CCDS17071.1
International Mouse Knockout Project StatusCd40
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016424 VEGA Gene Model | MGI Sequence Detail 17322 C57BL/6J ±  kb
transcript OTTMUST00000039545 VEGA | MGI Sequence Detail 2986 Not Applicable 
polypeptide OTTMUSP00000017667 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(15) UniProt(3)
Polymorphisms RFLP(5) : SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020435 Tumour necrosis factor receptor 5
Protein Ontology PR:000001961 tumor necrosis factor receptor superfamily member 5
References (Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:207011 Arcipowski KM, et al., TRAF6 is a critical regulator of LMP1 functions in vivo. Int Immunol. 2014 Mar;26(3):149-58
All references(350)
Other
accession IDs
MGD-MRK-1859, MGI:2138913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory