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Cd40
Gene Detail
Symbol

Name
ID
Cd40
CD40 antigen
MGI:88336
Synonyms
Bp50, Cd40, p50, Tnfrsf5
Feature Type
protein coding gene
Genetic Map
Chromosome 2
85.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr2:165055627-165072948 bp, + strand
From VEGA annotation of GRCm38

  17322 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CD40
Protein SuperFamily: tumor necrosis factor receptor superfamily member 5
Gene Tree: Cd40

Human
homologs
CD40, CD40 molecule, TNF receptor superfamily member 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 958
neXtProt AC: NX_P25942

Human Synonyms: Bp50, CDW40, p50, TNFRSF5

Human Chr (Location): 20q12-q13.2; chr20:46118250-46129745 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD40

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene may cause impaired immunoglobulin class switching and germinal center formation, reduced susceptibility to type II hypersensitivity reaction, impaired priming of T cells and control of M. tuberculosis infection, and altered response to transplant.
 
Interactions
Cd40 interacts with 248 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process B cell activation, cellular calcium ion homeostasis, ...
Component CD40 receptor complex, cell, ...
Function antigen binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CD40 ; Xenbase cd40 ; ZFIN cd40    NEW 
Molecular
reagents
All nucleic(35) Genomic(10) cDNA(24) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016424 (Evidence)
Ensembl Gene Model ENSMUSG00000017652 (Evidence)
Entrez Gene 21939 (Evidence)
UniGene 271833
DFCI TC1575459, TC1593855, TC1682219, TC1772398
DoTS DT.101194552, DT.110729823, DT.91339881, DT.99863551, DT.99863552, DT.99863553
NIA Mouse Gene Index U002826
Consensus CDS Project CCDS17069.1, CCDS17070.1, CCDS17071.1
International Mouse Phenotyping Consortium Status Cd40
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016424 VEGA Gene Model | MGI Sequence Detail 17322 C57BL/6J ±  kb
transcript OTTMUST00000039545 VEGA | MGI Sequence Detail 2986 Not Applicable 
polypeptide OTTMUSP00000017667 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(13) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020435 Tumour necrosis factor receptor 5
Protein Ontology PR:000001961 tumor necrosis factor receptor superfamily member 5
References
(Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:222667 Wolf D, et al., Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice. Circulation. 2014 Jun 10;129(23):2414-25
All references(359)
Other
accession IDs
MGD-MRK-1859, MGI:2138913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory