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Cd28 Gene Detail
Summary
  • Symbol
    Cd28
  • Name
    CD28 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88327
    NCBI Gene: 12487
  • Gene Overview
    MyGene.info: CD28
Location & Maps
more
  • Sequence Map
    Chr1:60716800-60773359 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.52 cM, cytoband C1-C3
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    CD28, CD28 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD28, CD28 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Tp44
  • Links
    NCBI Gene ID: 940
    neXtProt AC: NX_P10747

  • Chr Location
    2q33; chr2:203706475-203738912 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 8 alleles in 15 genetic backgrounds
    39 phenotypes from multigenic genotypes
    3 images
    285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Cd28
  • Incidental Mutations
Homozygous mutation of this gene results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002254 VEGA Gene Model | MGI Sequence Detail 56560 C57BL/6J ±  kb
transcript OTTMUST00000004499 VEGA | MGI Sequence Detail 4347 Not Applicable  
polypeptide OTTMUSP00000002157 VEGA | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    305 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001841 T-cell-specific surface glycoprotein CD28
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
    IPR008093 T cell antigen CD28
Molecular
Reagents
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  • All nucleic 37
    cDNA 37

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1845
References
more
  • Summaries
    All 390
    Developmental Gene Expression 1
    Gene Ontology 21
    Phenotypes 285
  • Earliest
    J:23361 Gross JA, et al., The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J Immunol. 1990 Apr 15;144(8):3201-10
  • Latest
    J:226243 Bolton HA, et al., Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest. 2015 Sep;125(9):3627-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory