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Cd22
Gene Detail
Symbol

Name
ID
Cd22
CD22 antigen
MGI:88322
Synonyms
Lyb8, Lyb-8
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:30865402-30880342 bp, - strand
From VEGA annotation of GRCm38

  14941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Cd22

Human
homologs
Human Homolog CD22, CD22 molecule
NCBI Gene ID 933
neXtProt AC  NX_P20273
Human Synonyms  SIGLEC2, SIGLEC-2
Human Chr (Location)  19q13.1; chr19:35329166-35347361 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens.
 
Interactions
Cd22 interacts with 133 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(22) Primer pair(1)
Microarray probesets(4)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049771 VEGA Gene Model | MGI Sequence Detail 14941 C57BL/6J ±  kb
transcript OTTMUST00000126799 VEGA | MGI Sequence Detail 3974 Not Applicable 
polypeptide OTTMUSP00000068550 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(21) UniProt(7)
Polymorphisms
RFLP(5) : SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000001288 B-cell receptor CD22
References
(Earliest) J:6945 Symington FW, et al., Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics. 1982;16(5):381-91
(Latest) J:208364 Poe JC, et al., EndoU is a novel regulator of AICD during peripheral B cell selection. J Exp Med. 2014 Jan 13;211(1):57-69
All references(107)
Other
accession IDs
MGD-MRK-12060, MGD-MRK-12066, MGD-MRK-1839

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory