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Cd22
Gene Detail
 Symbol
Name
ID
Cd22
CD22 antigen
MGI:88322
Synonyms Lyb8, Lyb-8
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:30865402-30880342 bp, - strand
From VEGA annotation of GRCm38

  14941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Cd22

Human
homologs
Human Homolog CD22, CD22 molecule
NCBI Gene ID 933
neXtProt AC  NX_P20273
Human Synonyms  SIGLEC2, SIGLEC-2
Human Chr (Location)  19q13.1; chr19:35329166-35347361 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens.
 
Interactions
Cd22 interacts with 133 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, cell surface receptor signaling pathway
Component external side of plasma membrane, extracellular vesicular exosome, ...
Function carbohydrate binding, coreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(22) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049771 (Evidence)
Ensembl Gene ModelENSMUSG00000030577 (Evidence)
Entrez Gene12483 (Evidence)
UniGene260994
DFCITC1581015, TC1588258, TC1623396, TC1660438, TC1692534, TC1694392
DoTSDT.101332297, DT.101360519, DT.101368681, DT.101387446, DT.101735692, DT.110994805, DT.110994813, DT.488385, DT.91339727, DT.91339728, DT.91339730, DT.91339731, DT.91339732, DT.91339734, DT.99858762
Consensus CDS ProjectCCDS21114.1
International Mouse Knockout Project StatusCd22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049771 VEGA Gene Model | MGI Sequence Detail 14941 C57BL/6J ±  kb
transcript OTTMUST00000126799 VEGA | MGI Sequence Detail 3974 Not Applicable 
polypeptide OTTMUSP00000068550 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(21) UniProt(7)
Polymorphisms RFLP(5) : SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000001288 B-cell receptor CD22
References (Earliest) J:6945 Symington FW, et al., Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics. 1982;16(5):381-91
(Latest) J:208364 Poe JC, et al., EndoU is a novel regulator of AICD during peripheral B cell selection. J Exp Med. 2014 Jan 13;211(1):57-69
All references(106)
Other
accession IDs
MGD-MRK-12060, MGD-MRK-12066, MGD-MRK-1839

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory