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Cd14
Gene Detail
Symbol

Name
ID
Cd14
CD14 antigen
MGI:88318
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:36725074-36726736 bp, - strand
From Ensembl annotation of GRCm38

  1663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD14
Protein SuperFamily: monocyte differentiation antigen CD14
Gene Tree: Cd14

Human
homologs
CD14, CD14 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 929
neXtProt AC: NX_P08571

Human Chr (Location): 5q31.1; chr5:140631728-140633701 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (other)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.
 
Interactions
Cd14 interacts with 34 markers (Mir23b, Mir30a, Mir30d, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(120)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(2) cDNA(120) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000051439 (Evidence)
Entrez Gene 12475 (Evidence)
UniGene 3460
DFCI TC1574770
DoTS DT.494761
PDB 1WWL
Consensus CDS Project CCDS29159.1
International Mouse Phenotyping Consortium Status Cd14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051439 Ensembl Gene Model | MGI Sequence Detail 1663 C57BL/6J ±  kb
transcript ENSMUST00000061829 Ensembl | MGI Sequence Detail 1572 Not Applicable 
polypeptide ENSMUSP00000056669 Ensembl | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR016337 Monocyte differentiation antigen CD14
Protein Ontology PR:000001889 CD14 molecule
References
(Earliest) J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
(Latest) J:222669 Tanimura N, et al., The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14
All references(172)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory