Cd14 MGI Mouse Gene Detail - MGI:88318

Cd14 Gene Detail

Symbol

Cd14
Name

CD14 antigen

Feature Type

protein coding gene
IDs

MGI:88318
NCBI Gene: 12475
Gene Overview

MyGene.info: CD14

Sequence Map

Chr18:36725074-36726736 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

1663 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

7 experiments

Human Ortholog

CD14, CD14 molecule

Vertebrate Orthologs

7

Human Ortholog

CD14, CD14 molecule
Orthology source: HomoloGene, HGNC
Links

HGNC:1628

NCBI Gene ID: 929

neXtProt AC: NX_P08571

UniProt: P08571
Chr Location

5q31.3; chr5:140631728-140633701 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 493
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CD14
Protein SuperFamily

monocyte differentiation antigen CD14
Gene Tree

Cd14

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Phenotype Summary

22 phenotypes from 3 alleles in 8 genetic backgrounds
2 phenotypes from multigenic genotypes
111 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.

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All GO Annotations

40
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

55
Tissues

50
cDNA Data

120
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Cd14 interacts with 34 markers (Mir23b, Mir30a, Mir30d, ...) View All

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All Sequences

25
RefSeq

2
UniProt

6
CCDS

CCDS29159.1
UniGene

3460

Ensembl

ENSMUSG00000051439 (Evidence)
NCBI Gene

12475

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051439	Ensembl Gene Model \| MGI Sequence Detail	1663	C57BL/6J	± kb
transcript	ENSMUST00000061829	Ensembl \| MGI Sequence Detail	1572	Not Applicable
polypeptide	ENSMUSP00000056669	Ensembl \| MGI Sequence Detail	366	Not Applicable

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SNPs within 2kb

51 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000001889 CD14 molecule

(term hierarchy)
PDB

1WWL
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain, L domain-like

IPR016337 Monocyte differentiation antigen CD14

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All nucleic 124

Genomic 2

cDNA 120

Primer pair 2

Microarray probesets 3

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MGD-MRK-1831

Summaries

All 182

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 111
Earliest

J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
Latest

J:242238 Buchheister S, et al., CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function. Am J Pathol. 2017 May;187(5):1106-1120

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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