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Cd14 Gene Detail
Summary
  • Symbol
    Cd14
  • Name
    CD14 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88318
    NCBI Gene: 12475
  • Gene Overview
    MyGene.info: CD14
Location & Maps
more
  • Sequence Map
    Chr18:36725074-36726736 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1663 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CD14, CD14 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD14, CD14 molecule
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 929
    neXtProt AC: NX_P08571

  • Chr Location
    5q31.1; chr5:140631728-140633701 (-)  GRCh38.p2
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
    Mutagenetix , APF
Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    55
  • Tissues
    50
  • cDNA Data
    120
  • Literature Summary
    3
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051439 Ensembl Gene Model | MGI Sequence Detail 1663 C57BL/6J ±  kb
transcript ENSMUST00000061829 Ensembl | MGI Sequence Detail 1572 Not Applicable  
polypeptide ENSMUSP00000056669 Ensembl | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001889 CD14 molecule
  • PDB
    1WWL
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR016337 Monocyte differentiation antigen CD14
Molecular
Reagents
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  • All nucleic 124
    Genomic 2
    cDNA 120
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1831
References
more
  • Summaries
    All 177
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 109
  • Earliest
    J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
  • Latest
    J:230432 Wang Y, et al., TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory