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Cd14 Gene Detail
Summary
  • Symbol
    Cd14
  • Name
    CD14 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88318
    NCBI Gene: 12475
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36858120-36859851 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88318
 protein coding gene Chr18:36858117-36859868 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024285
 protein coding gene Chr18:35136143-35137809 (-)
A/J MGP_AJ_G0024251
 protein coding gene Chr18:33898362-33900028 (-)
AKR/J MGP_AKRJ_G0024219
 protein coding gene Chr18:34854268-34855934 (-)
BALB/cJ MGP_BALBcJ_G0024251
 protein coding gene Chr18:33948574-33950240 (-)
C3H/HeJ MGP_C3HHeJ_G0024018
 protein coding gene Chr18:34916321-34917987 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024692
 protein coding gene Chr18:36372226-36373888 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022132
 protein coding gene Chr18:33992356-33994026 (-)
CAST/EiJ MGP_CASTEiJ_G0023493
 protein coding gene Chr18:34932323-34933989 (-)
CBA/J MGP_CBAJ_G0023986
 protein coding gene Chr18:37447607-37449273 (-)
DBA/2J MGP_DBA2J_G0024118
 protein coding gene Chr18:33516060-33517726 (-)
FVB/NJ MGP_FVBNJ_G0024085
 protein coding gene Chr18:33223859-33225525 (-)
LP/J MGP_LPJ_G0024200
 protein coding gene Chr18:35170829-35172495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024113
 protein coding gene Chr18:38663377-38665043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024741
 protein coding gene Chr18:34723323-34724989 (-)
PWK/PhJ MGP_PWKPhJ_G0023237
 protein coding gene Chr18:33777169-33778835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023044
 protein coding gene Chr18:34975860-34977540 (-)
WSB/EiJ MGP_WSBEiJ_G0023556
 protein coding gene Chr18:34644557-34646223 (-)



Homology
more
  • Human Ortholog
    CD14, CD14 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD14, CD14 molecule
  • Links
    NCBI Gene ID: 929
    neXtProt AC: NX_P08571
    UniProt: P08571

  • Chr Location
    5q31.3; chr5:140631728-140633701 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    11 with human CD14 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    52
  • cDNA Data
    121
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051439 Ensembl Gene Model | MGI Sequence Detail 1732 C57BL/6J ±  kb
    transcript ENSMUST00000061829 Ensembl | MGI Sequence Detail 1641 Not Applicable  
    polypeptide ENSMUSP00000056669 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      Genomic 2
      cDNA 121
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1831
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 137
    • Earliest
      J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
    • Latest
      J:306186 Pisko J, et al., Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres. Sci Rep. 2021 Apr 29;11(1):9228
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/09/2022
    MGI 6.21     		The Jackson Laboratory