Cd14 MGI Mouse Gene Detail - MGI:88318 - CD14 antigen

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Cd14 Gene Detail

Symbol

Cd14
Name

CD14 antigen

Feature Type

protein coding gene
IDs

MGI:88318
NCBI Gene: 12475
Alliance

gene page
Transcription Start Sites

12 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr18:36858120-36859851 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

7 experiments

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SNPs within 2kb

147 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_88318	protein coding gene	Chr18:36858117-36859868 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024285	protein coding gene	Chr18:35136143-35137809 (-)
A/J	MGP_AJ_G0024251	protein coding gene	Chr18:33898362-33900028 (-)
AKR/J	MGP_AKRJ_G0024219	protein coding gene	Chr18:34854268-34855934 (-)
BALB/cJ	MGP_BALBcJ_G0024251	protein coding gene	Chr18:33948574-33950240 (-)
C3H/HeJ	MGP_C3HHeJ_G0024018	protein coding gene	Chr18:34916321-34917987 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024692	protein coding gene	Chr18:36372226-36373888 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022132	protein coding gene	Chr18:33992356-33994026 (-)
CAST/EiJ	MGP_CASTEiJ_G0023493	protein coding gene	Chr18:34932323-34933989 (-)
CBA/J	MGP_CBAJ_G0023986	protein coding gene	Chr18:37447607-37449273 (-)
DBA/2J	MGP_DBA2J_G0024118	protein coding gene	Chr18:33516060-33517726 (-)
FVB/NJ	MGP_FVBNJ_G0024085	protein coding gene	Chr18:33223859-33225525 (-)
LP/J	MGP_LPJ_G0024200	protein coding gene	Chr18:35170829-35172495 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024113	protein coding gene	Chr18:38663377-38665043 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024741	protein coding gene	Chr18:34723323-34724989 (-)
PWK/PhJ	MGP_PWKPhJ_G0023237	protein coding gene	Chr18:33777169-33778835 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023044	protein coding gene	Chr18:34975860-34977540 (-)
WSB/EiJ	MGP_WSBEiJ_G0023556	protein coding gene	Chr18:34644557-34646223 (-)

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Human Ortholog

CD14, CD14 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD14, CD14 molecule
Links

HGNC:1628

NCBI Gene ID: 929

UniProt: P08571
Chr Location

5q31.3; chr5:140631728-140633701 (-) GRCh38

MGI Vertebrate Homology

Cd14 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD14
Protein SuperFamily

CD14
Gene Tree

Cd14

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Diseases

11 with human CD14 associations

				Human Disease	Mouse Models
				allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				celiac disease IDs celiac disease DOID:10608 EFO:0001060 ICD10CM:K90.0 ICD9CM:579.0 MESH:D002446 NCI:C26714 OMIM:607202 OMIM:609754 OMIM:611598 OMIM:612005 OMIM:612006 OMIM:612007 OMIM:612008 OMIM:612009 OMIM:612011 ORDO:555 UMLS_CUI:C0007570
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				rhinitis IDs rhinitis DOID:4483 MESH:D012220 NCI:C34986 UMLS_CUI:C0035455
				sarcoidosis IDs sarcoidosis DOID:11335 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 UMLS_CUI:C0036202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 3 alleles in 8 genetic backgrounds
2 phenotypes from multigenic genotypes
149 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

1
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.

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All GO Annotations

90
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

52
cDNA Data

121
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

6
CCDS

CCDS29159.1

Ensembl

ENSMUSG00000051439 (Evidence)
NCBI Gene

12475

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000051439	Ensembl Gene Model \| MGI Sequence Detail	1732	C57BL/6J	± kb
	transcript	ENSMUST00000061829	Ensembl \| MGI Sequence Detail	1641	Not Applicable
	polypeptide	ENSMUSP00000056669	Ensembl \| MGI Sequence Detail	366	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001889 CD14 molecule

(term hierarchy)
PDB

1WWL
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR016337 Monocyte differentiation antigen CD14
GlyGen

P10810 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 126

Genomic 2

cDNA 121

Primer pair 3

Microarray probesets 3

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MGD-MRK-1831

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Summaries

All 248

Developmental Gene Expression 5

Gene Ontology 16

Phenotypes 149
Earliest

J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
Latest

J:365671 Magri Z, et al., CD14 is a decision-maker between Fas-mediated death and inflammation. Cell Rep. 2024 Sep 24;43(9):114685

TSS for Cd14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152967	Chr18:36859830-36859835 (-)	18 bp
Tssr152966	Chr18:36859783-36859798 (-)	60 bp
Tssr152965	Chr18:36859769-36859777 (-)	78 bp
Tssr152964	Chr18:36859721-36859744 (-)	118 bp
Tssr152963	Chr18:36859645-36859668 (-)	194 bp
Tssr152962	Chr18:36859624-36859639 (-)	219 bp
Tssr152961	Chr18:36859388-36859402 (-)	456 bp
Tssr152960	Chr18:36859331-36859354 (-)	508 bp
Tssr152959	Chr18:36859253-36859279 (-)	585 bp
Tssr152958	Chr18:36859225-36859239 (-)	619 bp
Tssr152957	Chr18:36859161-36859169 (-)	686 bp
Tssr152956	Chr18:36858150-36858180 (-)	1,686 bp

Cd14 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bwq4	Chr18, 18.83 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.
Cdcs6	Chr18, syntenic		J:154082	The mouse Cd14 gene is within the interval of Cdcs6. Cd14 was considered a good candidate gene because of expression differences between C57BL/6J mice (low Cd14 expression, conferring susceptibility) and C3/J-Il10 mice (high Cd14 expression, presumably conferring resistance).
Cdcs6	Chr18, syntenic		J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.
Nidd2	Chr18, 18.04 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.

*cM position of peak correlated region/marker

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