Cd14 MGI Mouse Gene Detail - MGI:88318

Symbol

Cd14
Name

CD14 antigen

Feature Type

protein coding gene
IDs

MGI:88318
NCBI Gene: 12475
Gene Overview

MyGene.info: CD14
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr18:36725074-36726736 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

7 experiments

SNPs within 2kb

51 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88318	protein coding gene	Chr18:36725064-36726815 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024285	protein coding gene	Chr18:35136143-35137809 (-)
A/J	MGP_AJ_G0024251	protein coding gene	Chr18:33898362-33900028 (-)
AKR/J	MGP_AKRJ_G0024219	protein coding gene	Chr18:34854268-34855934 (-)
BALB/cJ	MGP_BALBcJ_G0024251	protein coding gene	Chr18:33948574-33950240 (-)
C3H/HeJ	MGP_C3HHeJ_G0024018	protein coding gene	Chr18:34916321-34917987 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024692	protein coding gene	Chr18:36372226-36373888 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022132	protein coding gene	Chr18:33992356-33994026 (-)
CAST/EiJ	MGP_CASTEiJ_G0023493	protein coding gene	Chr18:34932323-34933989 (-)
CBA/J	MGP_CBAJ_G0023986	protein coding gene	Chr18:37447607-37449273 (-)
DBA/2J	MGP_DBA2J_G0024118	protein coding gene	Chr18:33516060-33517726 (-)
FVB/NJ	MGP_FVBNJ_G0024085	protein coding gene	Chr18:33223859-33225525 (-)
LP/J	MGP_LPJ_G0024200	protein coding gene	Chr18:35170829-35172495 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024113	protein coding gene	Chr18:38663377-38665043 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024741	protein coding gene	Chr18:34723323-34724989 (-)
PWK/PhJ	MGP_PWKPhJ_G0023237	protein coding gene	Chr18:33777169-33778835 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023044	protein coding gene	Chr18:34975860-34977540 (-)
WSB/EiJ	MGP_WSBEiJ_G0023556	protein coding gene	Chr18:34644557-34646223 (-)

Human Ortholog

CD14, CD14 molecule

Vertebrate Orthologs

7

Human Ortholog

CD14, CD14 molecule
Orthology source: HomoloGene, HGNC
Links

HGNC:1628

NCBI Gene ID: 929

neXtProt AC: NX_P08571

UniProt: P08571
Chr Location

5q31.3; chr5:140631728-140633701 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 493
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CD14
Protein SuperFamily

monocyte differentiation antigen CD14
Gene Tree

Cd14

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Phenotype Summary

22 phenotypes from 3 alleles in 8 genetic backgrounds
2 phenotypes from multigenic genotypes
119 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.

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All GO Annotations

67
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

55
Tissues

50
cDNA Data

121
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Cd14 interacts with 34 markers (Mir23b, Mir30a, Mir30d, ...) View All

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All Sequences

43
RefSeq

2
UniProt

6
CCDS

CCDS29159.1
UniGene

3460

Ensembl

ENSMUSG00000051439 (Evidence)
NCBI Gene

12475

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051439	Ensembl Gene Model \| MGI Sequence Detail	1663	C57BL/6J	± kb
transcript	ENSMUST00000061829	Ensembl \| MGI Sequence Detail	1572	Not Applicable
polypeptide	ENSMUSP00000056669	Ensembl \| MGI Sequence Detail	366	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001889 CD14 molecule

(term hierarchy)
PDB

1WWL
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR016337 Monocyte differentiation antigen CD14

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All nucleic 125

Genomic 2

cDNA 121

Primer pair 2

Microarray probesets 3

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MGD-MRK-1831

Summaries

All 207

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 119
Earliest

J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
Latest

J:268056 Sambamurthy N, et al., Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PLoS One. 2018;13(11):e0206217

TSS for Cd14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152967	Chr18:36726777-36726782 (-)	-44 bp
Tssr152966	Chr18:36726730-36726745 (-)	-2 bp
Tssr152965	Chr18:36726716-36726724 (-)	16 bp
Tssr152964	Chr18:36726668-36726691 (-)	56 bp
Tssr152963	Chr18:36726592-36726615 (-)	132 bp
Tssr152962	Chr18:36726571-36726586 (-)	157 bp
Tssr152961	Chr18:36726335-36726349 (-)	394 bp
Tssr152960	Chr18:36726278-36726301 (-)	446 bp
Tssr152959	Chr18:36726200-36726226 (-)	523 bp
Tssr152958	Chr18:36726172-36726186 (-)	557 bp
Tssr152957	Chr18:36726108-36726116 (-)	624 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/15/2019 MGI 6.13