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Cd14
Gene Detail
 Symbol
Name
ID
Cd14
CD14 antigen
MGI:88318
Feature Type protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:36725067-36726654 bp, - strand
From NCBI annotation of GRCm38

  1588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: monocyte differentiation antigen CD14
Gene Tree: Cd14

Human
homologs
Human Homolog CD14, CD14 molecule
NCBI Gene ID 929
neXtProt AC  NX_P08571
Human Chr (Location)  5q31.1; chr5:140631728-140633701 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (other)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.
 
Interactions
Cd14 interacts with 34 markers (Mir23b, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, ...
Component anchored component of membrane, cell surface, ...
Function lipopolysaccharide binding, lipoteichoic acid binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(120)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(2) cDNA(120) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051439 (Evidence)
Entrez Gene12475 (Evidence)
UniGene3460
DFCITC1574770
DoTSDT.494761
PDB1WWL
Consensus CDS ProjectCCDS29159.1
International Mouse Knockout Project StatusCd14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12475 NCBI Gene Model | MGI Sequence Detail 1588 C57BL/6J ±  kb
transcript NM_009841 RefSeq | MGI Sequence Detail 1681 C57BL/6 
polypeptide P10810 UniProt | EBI | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR016337 Monocyte differentiation antigen CD14
Protein Ontology PR:000001889 CD14 molecule
Graphical View of Protein Domain Structure
References (Earliest) J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
(Latest) J:210048 Almeida PE, et al., Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection. Biochim Biophys Acta. 2014 Jan;1841(1):97-107
All references(167)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory