Cd14
Gene Detail

Symbol

Name
ID

Cd14
CD14 antigen
MGI:88318

Feature Type

protein coding gene

Genetic Map

Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr18:36725067-36726654 bp, - strand From NCBI annotation of GRCm38   1588 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: monocyte differentiation antigen CD14
Gene Tree: Cd14

Human
homologs

Human Homolog		CD14, CD14 molecule
NCBI Gene ID		929
neXtProt AC		NX_P08571
Human Chr (Location)		5q31.1; chr5:140631728-140633701 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Chemically induced (other)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.

 

Interactions

Cd14 interacts with 34 markers (Mir23b, Mir30a, Mir30d, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, ...
Component	anchored component of membrane, cell surface, ...
Function	lipopolysaccharide binding, lipoteichoic acid binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	46

cDNA source data(120)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(123) Genomic(2) cDNA(120) Primer pair(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000051439 (Evidence)
Entrez Gene	12475 (Evidence)
UniGene	3460
DFCI	TC1574770
DoTS	DT.494761
PDB	1WWL
Consensus CDS Project	CCDS29159.1
International Mouse Knockout Project Status	Cd14

Sequences

Length	Strain/Species
genomic	12475	NCBI Gene Model | MGI Sequence Detail	1588	C57BL/6J
transcript	NM_009841	RefSeq | MGI Sequence Detail	1681	C57BL/6
polypeptide	P10810	UniProt | EBI | MGI Sequence Detail	366	Not Applicable

All sequences(32) RefSeq(2) UniProt(11)

Polymorphisms

SNPs within 2kb(55 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR016337	Monocyte differentiation antigen CD14
Protein Ontology	PR:000001889	CD14 molecule

Graphical View of Protein Domain Structure

References

(Earliest) J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
(Latest) J:210048 Almeida PE, et al., Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection. Biochim Biophys Acta. 2014 Jan;1841(1):97-107
All references(167)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-1831