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Cd14 Gene Detail
Summary
  • Symbol
    Cd14
  • Name
    CD14 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88318
    NCBI Gene: 12475
  • Gene Overview
    MyGene.info: CD14
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36725074-36726736 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88318
protein coding gene Chr18:36725064-36726815 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024285
protein coding gene Chr18:35136143-35137809 (-)
A/J MGP_AJ_G0024251
protein coding gene Chr18:33898362-33900028 (-)
AKR/J MGP_AKRJ_G0024219
protein coding gene Chr18:34854268-34855934 (-)
BALB/cJ MGP_BALBcJ_G0024251
protein coding gene Chr18:33948574-33950240 (-)
C3H/HeJ MGP_C3HHeJ_G0024018
protein coding gene Chr18:34916321-34917987 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024692
protein coding gene Chr18:36372226-36373888 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022132
protein coding gene Chr18:33992356-33994026 (-)
CAST/EiJ MGP_CASTEiJ_G0023493
protein coding gene Chr18:34932323-34933989 (-)
CBA/J MGP_CBAJ_G0023986
protein coding gene Chr18:37447607-37449273 (-)
DBA/2J MGP_DBA2J_G0024118
protein coding gene Chr18:33516060-33517726 (-)
FVB/NJ MGP_FVBNJ_G0024085
protein coding gene Chr18:33223859-33225525 (-)
LP/J MGP_LPJ_G0024200
protein coding gene Chr18:35170829-35172495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024113
protein coding gene Chr18:38663377-38665043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024741
protein coding gene Chr18:34723323-34724989 (-)
PWK/PhJ MGP_PWKPhJ_G0023237
protein coding gene Chr18:33777169-33778835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023044
protein coding gene Chr18:34975860-34977540 (-)
WSB/EiJ MGP_WSBEiJ_G0023556
protein coding gene Chr18:34644557-34646223 (-)



Homology
more
  • Human Ortholog
    CD14, CD14 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD14, CD14 molecule
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 929
    neXtProt AC: NX_P08571
    UniProt: P08571

  • Chr Location
    5q31.3; chr5:140631728-140633701 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit macrophages with impaired responses to LPS or E.coli, resulting in a reduction or loss of cytokine production. Macrophages also cannot contain vesicular stomatitis virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051439 Ensembl Gene Model | MGI Sequence Detail 1663 C57BL/6J ±  kb
    transcript ENSMUST00000061829 Ensembl | MGI Sequence Detail 1572 Not Applicable  
    polypeptide ENSMUSP00000056669 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      Genomic 2
      cDNA 121
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1831
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 116
    • Earliest
      J:9682 Matsuura K, et al., Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132
    • Latest
      J:264670 Davis S, et al., Phagocytosis-mediated M1 activation by chitin but not by chitosan. Am J Physiol Cell Physiol. 2018 Jul 1;315(1):C62-C72

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory