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Cacna1b
Gene Detail
Symbol

Name
ID
Cacna1b
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI:88296
Synonyms
alpha(1B), Cav2.2, Cchn1a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.58 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:24603887-24763152 bp, - strand
From VEGA annotation of GRCm38

  159266 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: CACNA1B
Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1b

Human
homologs
CACNA1B, calcium channel, voltage-dependent, N type, alpha 1B subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 774
neXtProt AC: NX_Q00975

Human Synonyms: BIII, CACNL1A5, CACNN, Cav2.2, DYT23

Human Chr (Location): 9q34; chr9:137877789-138124624 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CACNA1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation.
 
Interactions
Cacna1b interacts with 376 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component axon terminus, cell, ...
Function ATP binding, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (57)    Tissues (35)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
RT-PCR 27
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cacna1ba, cacna1bb    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(14) Primer pair(5) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000012011 (Evidence)
Ensembl Gene Model ENSMUSG00000004113 (Evidence)
Entrez Gene 12287 (Evidence)
DFCI TC1585624, TC1629109, TC1636423, TC1661917
DoTS DT.40170618, DT.87072237
NIA Mouse Gene Index U022366
Consensus CDS Project CCDS15739.1, CCDS38065.1
International Mouse Phenotyping Consortium Status Cacna1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012011 VEGA Gene Model | MGI Sequence Detail 159266 C57BL/6J ±  kb
transcript OTTMUST00000029152 VEGA | MGI Sequence Detail 6987 Not Applicable 
polypeptide OTTMUSP00000013174 VEGA | MGI Sequence Detail 2328 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(36) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(1161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR005821 Ion transport domain
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
InterPro IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro IPR005447 Voltage-dependent calcium channel, N-type, alpha-1 subunit
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000002117 voltage-dependent N-type calcium channel subunit alpha-1B
References
(Earliest) J:16589 Coppola T, et al., Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization. FEBS Lett. 1994 Jan 24;338(1):1-5
(Latest) J:210619 Duan JH, et al., N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice. Neuroscience. 2014 Jun 13;270:192-202
All references(88)
Other
accession IDs
MGD-MRK-1803, MGI:2139282, MGI:2139293, MGI:2139419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory