Cacna1b
Gene Detail

Symbol Name ID

Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit MGI:88296

Synonyms

alpha(1B), Cav2.2, Cchn1a

Feature Type

protein coding gene

Genetic Map

Chromosome 2

16.58 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr2:24603887-24763152 bp, - strand From VEGA annotation of GRCm38   159266 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1b

Human homologs

Human Homolog		CACNA1B, calcium channel, voltage-dependent, N type, alpha 1B subunit
NCBI Gene ID		774
neXtProt AC		NX_Q00975
Human Synonyms		BIII, CACNL1A5, CACNN, Cav2.2
Human Chr (Location)		9q34; chr9:140772241-141019076 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	calcium ion import, calcium ion transmembrane transport, ...
Component	axon terminus, dendrite, ...
Function	ATP binding, calcium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (53)    Tissues (30)    Images (6)
Theiler Stages: 12, 15, 20, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	30
RT-PCR	23

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000012011 (Evidence)
Ensembl Gene Model	ENSMUSG00000004113 (Evidence)
Entrez Gene	12287 (Evidence)
DFCI	TC1585624, TC1629109, TC1636423, TC1661917
DoTS	DT.40170618, DT.87072237
NIA Mouse Gene Index	U022366
Consensus CDS Project	CCDS15739.1, CCDS38065.1
International Mouse Knockout Project Status	Cacna1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012011	VEGA Gene Model | MGI Sequence Detail	159266	C57BL/6J
transcript	OTTMUST00000029152	VEGA | MGI Sequence Detail	6987	Not Applicable
polypeptide	OTTMUSP00000013174	VEGA | MGI Sequence Detail	2328	Not Applicable

All sequences(69) RefSeq(4) UniProt(10)

Polymorphisms

RFLP(2) : SNPs(869 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018249	EF-HAND 2
InterPro	IPR005821	Ion transport domain
InterPro	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
InterPro	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro	IPR005447	Voltage-dependent calcium channel, N-type, alpha-1 subunit
Protein Ontology	PR:000002117	voltage-dependent N-type calcium channel subunit alpha-1B

References

(Earliest) J:16589 Coppola T, et al., Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization. FEBS Lett. 1994 Jan 24;338(1):1-5
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(81)

Other accession IDs

MGD-MRK-1803, MGI:2139282, MGI:2139293, MGI:2139419