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Cacna1b
Gene Detail
Symbol

Name
ID
Cacna1b
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI:88296
Synonyms
alpha(1B), Cav2.2, Cchn1a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.58 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:24603887-24763152 bp, - strand
From VEGA annotation of GRCm38

  159266 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: voltage-gated calcium channel
Gene Tree: Cacna1b

Human
homologs
Human Homolog CACNA1B, calcium channel, voltage-dependent, N type, alpha 1B subunit
NCBI Gene ID 774
neXtProt AC  NX_Q00975
Human Synonyms  BIII, CACNL1A5, CACNN, Cav2.2
Human Chr (Location)  9q34; chr9:137877789-138124624 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation.
 
Interactions
Cacna1b interacts with 376 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component axon terminus, cell, ...
Function ATP binding, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (53)    Tissues (34)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
RT-PCR 23
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000012011 (Evidence)
Ensembl Gene ModelENSMUSG00000004113 (Evidence)
Entrez Gene12287 (Evidence)
DFCITC1585624, TC1661917, TC1636423, TC1629109
DoTSDT.40170618, DT.87072237
NIA Mouse Gene IndexU022366
Consensus CDS ProjectCCDS15739.1, CCDS38065.1
International Mouse Knockout Project StatusCacna1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012011 VEGA Gene Model | MGI Sequence Detail 159266 C57BL/6J ±  kb
transcript OTTMUST00000029152 VEGA | MGI Sequence Detail 6987 Not Applicable 
polypeptide OTTMUSP00000013174 VEGA | MGI Sequence Detail 2328 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(36) UniProt(17)
Polymorphisms
RFLP(2) : SNPs within 2kb(1161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR005821 Ion transport domain
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
InterPro IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
InterPro IPR005447 Voltage-dependent calcium channel, N-type, alpha-1 subunit
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000002117 voltage-dependent N-type calcium channel subunit alpha-1B
References
(Earliest) J:16589 Coppola T, et al., Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization. FEBS Lett. 1994 Jan 24;338(1):1-5
(Latest) J:210619 Duan JH, et al., N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice. Neuroscience. 2014 Jun 13;270:192-202
All references(88)
Other
accession IDs
MGD-MRK-1803, MGI:2139282, MGI:2139293, MGI:2139419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory