Cacna2d1
Gene Detail

Symbol Name ID

Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 MGI:88295

Synonyms

Cacna2, Ca(v)alpha2delta1, Cchl2a

Feature Type

protein coding gene

Genetic Map

Chromosome 5

6.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr5:15934691-16374511 bp, + strand From NCBI annotation of GRCm38   439821 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d1

Human homologs

Human Homolog		CACNA2D1, calcium channel, voltage-dependent, alpha 2/delta subunit 1
NCBI Gene ID		781
neXtProt AC		NX_P54289
Human Synonyms		CACNA2, CACNL2A, CCHL2A
Human Chr (Location)		7q21-q22; chr7:81579418-82073031 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice with a point mutation allele exhibit abnormal CNS synaptic transmission and decreased response to pregabalin.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, membrane, ...
Function	calcium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (179)    Tissues (43)    Images (25)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	158
RT-PCR	21

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(28) Primer pair(5)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000040118 (Evidence)
Entrez Gene	12293 (Evidence)
DFCI	TC1583783, TC1592023, TC1594526, TC1598457, TC1620949, TC1775772
DoTS	DT.101365391, DT.101715376, DT.40148582, DT.91334896, DT.91338426, DT.91562964, DT.97334162
NIA Mouse Gene Index	U158202
Consensus CDS Project	CCDS19096.1, CCDS51421.1, CCDS51422.1, CCDS51423.1
International Mouse Knockout Project Status	Cacna2d1

Sequences

Length	Strain/Species
genomic	12293	NCBI Gene Model | MGI Sequence Detail	439821	C57BL/6J
transcript	NM_001110843	RefSeq | MGI Sequence Detail	7472	C57BL/6
polypeptide	O08532	UniProt | EBI | MGI Sequence Detail	1103	Not Applicable

All sequences(59) RefSeq(10) UniProt(5)

Polymorphisms

RFLP(3) : SNPs(2182 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004010	Cache domain
InterPro	IPR013680	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR013608	VWA N-terminal
Protein Ontology	PR:000004942	voltage-dependent calcium channel subunit alpha-2/delta-1

Graphical View of Protein Domain Structure

References

(Earliest) J:1673 Chin H, et al., The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5. Genomics. 1992 Aug;13(4):1325-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(53)

Other accession IDs

MGD-MRK-1801