Cacna2d1
Gene Detail

Symbol

Name
ID

Cacna2d1
calcium channel, voltage-dependent, alpha2/delta subunit 1
MGI:88295

Synonyms

Cacna2, Ca(v)alpha2delta1, Cchl2a

Feature Type

protein coding gene

Genetic Map

Chromosome 5
6.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr5:15934691-16374511 bp, + strand From NCBI annotation of GRCm38   439821 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d1

Human
homologs

Human Homolog		CACNA2D1, calcium channel, voltage-dependent, alpha 2/delta subunit 1
NCBI Gene ID		781
neXtProt AC		NX_P54289
Human Synonyms		CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3
Human Chr (Location)		7q21-q22; chr7:81946444-82443715 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice with a point mutation allele exhibit abnormal CNS synaptic transmission and decreased response to pregabalin.

 

Interactions

Cacna2d1 interacts with 483 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (24 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	extracellular vesicular exosome, integral component of membrane, ...
Function	calcium channel activity, calcium channel regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (179)    Tissues (46)    Images (25)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	158
RT-PCR	21

cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(33) cDNA(28) Primer pair(5)
Microarray probesets(7)

Other database
links

Ensembl Gene Model	ENSMUSG00000040118 (Evidence)
Entrez Gene	12293 (Evidence)
DFCI	TC1594526, TC1598457, TC1592023, TC1583783, TC1775772, TC1620949
DoTS	DT.91334896, DT.101365391, DT.40148582, DT.101715376, DT.97334162, DT.91562964, DT.91338426
NIA Mouse Gene Index	U158202
Consensus CDS Project	CCDS19096.1, CCDS51421.1, CCDS51422.1, CCDS51423.1
International Mouse Knockout Project Status	Cacna2d1

Sequences

Length	Strain/Species
genomic	12293	NCBI Gene Model | MGI Sequence Detail	439821	C57BL/6J
transcript	NM_001110843	RefSeq | MGI Sequence Detail	7472	C57BL/6
polypeptide	O08532	UniProt | EBI | MGI Sequence Detail	1103	Not Applicable

All sequences(67) RefSeq(18) UniProt(5)

Polymorphisms

RFLP(3) : SNPs within 2kb(2704 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004010	Cache domain
InterPro	IPR013680	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR013608	VWA N-terminal
Protein Ontology	PR:000004942	voltage-dependent calcium channel subunit alpha-2/delta-1

Graphical View of Protein Domain Structure

References

(Earliest) J:1673 Chin H, et al., The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5. Genomics. 1992 Aug;13(4):1325-7
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(56)

Other
accession IDs

MGD-MRK-1801