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Cacna2d1
Gene Detail
 Symbol
Name
ID
Cacna2d1
calcium channel, voltage-dependent, alpha2/delta subunit 1
MGI:88295
Synonyms Cacna2, Ca(v)alpha2delta1, Cchl2a
Feature Type protein coding gene
Genetic Map
Chromosome 5
6.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr5:15934691-16374511 bp, + strand
From NCBI annotation of GRCm38

  439821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d1

Human
homologs
Human Homolog CACNA2D1, calcium channel, voltage-dependent, alpha 2/delta subunit 1
NCBI Gene ID 781
neXtProt AC  NX_P54289
Human Synonyms  CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3
Human Chr (Location)  7q21-q22; chr7:81946444-82443715 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with a point mutation allele exhibit abnormal CNS synaptic transmission and decreased response to pregabalin.
 
Interactions
Cacna2d1 interacts with 483 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function calcium channel activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (179)    Tissues (43)    Images (25)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 158
RT-PCR 21
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(28) Primer pair(5)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000040118 (Evidence)
Entrez Gene12293 (Evidence)
DFCITC1583783, TC1592023, TC1594526, TC1598457, TC1620949, TC1775772
DoTSDT.101365391, DT.101715376, DT.40148582, DT.91334896, DT.91338426, DT.91562964, DT.97334162
NIA Mouse Gene IndexU158202
Consensus CDS ProjectCCDS19096.1, CCDS51421.1, CCDS51422.1, CCDS51423.1
International Mouse Knockout Project StatusCacna2d1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12293 NCBI Gene Model | MGI Sequence Detail 439821 C57BL/6J ±  kb
transcript NM_001110843 RefSeq | MGI Sequence Detail 7472 C57BL/6 
polypeptide O08532 UniProt | EBI | MGI Sequence Detail 1103 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(18) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(2704 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004010 Cache domain
InterPro IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
InterPro IPR002035 von Willebrand factor, type A
InterPro IPR013608 VWA N-terminal
Protein Ontology PR:000004942 voltage-dependent calcium channel subunit alpha-2/delta-1
Graphical View of Protein Domain Structure
References (Earliest) J:1673 Chin H, et al., The gene for the dihydropyridine-sensitive calcium channel alpha 2 subunit (CCHL2A) maps to the proximal region of mouse chromosome 5. Genomics. 1992 Aug;13(4):1325-7
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(55)
Other
accession IDs
MGD-MRK-1801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory