Cbl
Gene Detail

Symbol Name ID

Cbl Casitas B-lineage lymphoma MGI:88279

Synonyms

4732447J05Rik, Cbl-2, c-Cbl

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr9:44149262-44234046 bp, - strand From NCBI annotation of GRCm38   84785 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase Cbl
Gene Tree: Cbl

Human homologs

Human Homolog		CBL, Cbl proto-oncogene, E3 ubiquitin protein ligase
NCBI Gene ID		867
neXtProt AC		NX_P22681
Human Synonyms		CBL2, C-CBL, FRA11B, NSLL, RNF55
Human Chr (Location)		11q23.3; chr11:119076986-119178859 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CBL

Alleles and phenotypes

All alleles(18) : Targeted(9) Gene trapped(9)
 

Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell surface receptor signaling pathway, metabolic process, ...
Component	cytoplasm, flotillin complex, ...
Function	calcium ion binding, ephrin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (134)    Tissues (132)    Images (5)
Theiler Stages: 17, 18, 21, 22, 23

Assay Type	Results
RNA in situ	134

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(145) Genomic(4) cDNA(135) Primer pair(1) Other(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000034342 (Evidence)
Entrez Gene	12402 (Evidence)
UniGene	266871
DFCI	TC1579852, TC1613263, TC1644313, TC1693467
DoTS	DT.101724794, DT.40164337, DT.55281861
NIA Mouse Gene Index	U030762
EC	6.3.2.-
PDB	2D9S
Consensus CDS Project	CCDS40598.1
International Mouse Knockout Project Status	Cbl

Sequences

Length	Strain/Species
genomic	12402	NCBI Gene Model | MGI Sequence Detail	84785	C57BL/6J
transcript	NM_007619	RefSeq | MGI Sequence Detail	5083	C57BL/6
polypeptide	P22682	UniProt | EBI | MGI Sequence Detail	913	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(480 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024162	Adaptor protein Cbl
InterPro	IPR014741	Adaptor protein Cbl, EF hand-like
InterPro	IPR003153	Adaptor protein Cbl, N-terminal helical
InterPro	IPR024159	Adaptor protein Cbl, PTB domain
InterPro	IPR014742	Adaptor protein Cbl, SH2-like
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR000980	SH2 domain
InterPro	IPR009060	UBA-like
InterPro	IPR000449	Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000005070	E3 ubiquitin-protein ligase CBL

Graphical View of Protein Domain Structure

References

(Earliest) J:12104 Dressler GR, et al., Murine genes with homology to Drosophila segmentation genes. Development. 1988;104 Suppl:181-6
(Latest) J:195089 Zuo W, et al., c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-beta type II receptor. Mol Cell. 2013 Feb 7;49(3):499-510
All references(119)

Other accession IDs

MGD-MRK-1779, MGD-MRK-1780, MGD-MRK-1782, MGI:2443367