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Cbl
Gene Detail
Symbol

Name
ID
Cbl
Casitas B-lineage lymphoma
MGI:88279
Synonyms
4732447J05Rik, Cbl-2, c-Cbl
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr9:44149262-44234046 bp, - strand
From Ensembl annotation of GRCm38

  84785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CBL
Protein SuperFamily: E3 ubiquitin-protein ligase Cbl
Gene Tree: Cbl

Human
homologs
CBL, Cbl proto-oncogene, E3 ubiquitin protein ligase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 867
neXtProt AC: NX_P22681

Human Synonyms: CBL2, C-CBL, FRA11B, NSLL, RNF55

Human Chr (Location): 11q23.3; chr11:119206276-119308149 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CBL

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(9) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.
 
Interactions
Cbl interacts with 295 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (134)    Tissues (132)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 134
cDNA source data(123)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cbl ; ZFIN cbl    NEW 
Molecular
reagents
All nucleic(133) Genomic(4) cDNA(123) Primer pair(1) Other(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000034342 (Evidence)
Entrez Gene 12402 (Evidence)
UniGene 266871
DFCI TC1579852, TC1613263, TC1644313, TC1693467
DoTS DT.101724794, DT.40164337, DT.55281861
NIA Mouse Gene Index U030762
EC 6.3.2.-
PDB 2D9S
Consensus CDS Project CCDS40598.1
International Mouse Phenotyping Consortium Status Cbl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034342 Ensembl Gene Model | MGI Sequence Detail 84785 C57BL/6J ±  kb
transcript ENSMUST00000037644 Ensembl | MGI Sequence Detail 5083 Not Applicable 
polypeptide ENSMUSP00000041902 Ensembl | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(7) : SNPs within 2kb(689 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024162 Adaptor protein Cbl
InterPro IPR014741 Adaptor protein Cbl, EF hand-like
InterPro IPR003153 Adaptor protein Cbl, N-terminal helical
InterPro IPR024159 Adaptor protein Cbl, PTB domain
InterPro IPR014742 Adaptor protein Cbl, SH2-like
InterPro IPR011992 EF-hand-like domain
InterPro IPR000980 SH2 domain
InterPro IPR009060 UBA-like
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000005070 E3 ubiquitin-protein ligase CBL
References
(Earliest) J:12104 Dressler GR, et al., Murine genes with homology to Drosophila segmentation genes. Development. 1988;104 Suppl:181-6
(Latest) J:221846 Rafiq K, et al., c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia. Circulation. 2014 May 20;129(20):2031-43
All references(128)
Other
accession IDs
MGD-MRK-1779, MGD-MRK-1780, MGD-MRK-1782, MGI:2443367

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory