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Cbl
Gene Detail
 Symbol
Name
ID
Cbl
Casitas B-lineage lymphoma
MGI:88279
Synonyms 4732447J05Rik, Cbl-2, c-Cbl
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr9:44149262-44234046 bp, - strand
From NCBI annotation of GRCm38

  84785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase Cbl
Gene Tree: Cbl

Human
homologs
Human Homolog CBL, Cbl proto-oncogene, E3 ubiquitin protein ligase
NCBI Gene ID 867
neXtProt AC  NX_P22681
Human Synonyms  CBL2, C-CBL, FRA11B, NSLL, RNF55
Human Chr (Location)  11q23.3; chr11:119206276-119308149 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CBL
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(9) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit increased thymic CD3 and CD4 expression and tyrosine-phosphorylation, lymphoid hyperplasia, and altered splenic hemopoiesis. Females show increased ductal density and branching in mammary fat pads.
 
Interactions
Cbl interacts with 296 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell surface receptor signaling pathway, negative regulation of apoptotic process, ...
Component cytoplasm, flotillin complex, ...
Function calcium ion binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (134)    Tissues (132)    Images (5)
Theiler Stages: 17, 18, 21, 22, 23
Assay TypeResults
RNA in situ 134
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) Genomic(4) cDNA(123) Primer pair(1) Other(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000034342 (Evidence)
Entrez Gene12402 (Evidence)
UniGene266871
DFCITC1579852, TC1613263, TC1644313, TC1693467
DoTSDT.101724794, DT.40164337, DT.55281861
NIA Mouse Gene IndexU030762
EC6.3.2.-
PDB2D9S
Consensus CDS ProjectCCDS40598.1
International Mouse Knockout Project StatusCbl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12402 NCBI Gene Model | MGI Sequence Detail 84785 C57BL/6J ±  kb
transcript NM_007619 RefSeq | MGI Sequence Detail 5083 C57BL/6 
polypeptide P22682 UniProt | EBI | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(2)
Polymorphisms RFLP(7) : SNPs within 2kb(689 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024162 Adaptor protein Cbl
InterPro IPR014741 Adaptor protein Cbl, EF hand-like
InterPro IPR003153 Adaptor protein Cbl, N-terminal helical
InterPro IPR024159 Adaptor protein Cbl, PTB domain
InterPro IPR014742 Adaptor protein Cbl, SH2-like
InterPro IPR011992 EF-hand-like domain
InterPro IPR000980 SH2 domain
InterPro IPR009060 UBA-like
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000005070 E3 ubiquitin-protein ligase CBL
Graphical View of Protein Domain Structure
References (Earliest) J:12104 Dressler GR, et al., Murine genes with homology to Drosophila segmentation genes. Development. 1988;104 Suppl:181-6
(Latest) J:206833 Leiser D, et al., Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation. FEBS Lett. 2014 Mar 3;588(5):653-8
All references(126)
Other
accession IDs
MGD-MRK-1779, MGD-MRK-1780, MGD-MRK-1782, MGI:2443367

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory