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Serpina6
Gene Detail
Symbol

Name
ID
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
MGI:88278
Synonyms
Cbg
Feature Type
protein coding gene
Genetic Map
Chromosome 12
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr12:103646630-103657212 bp, - strand
From VEGA annotation of GRCm38

  10583 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SERPINA6
Protein SuperFamily: serpin
Gene Tree: Serpina6

Human
homologs
SERPINA6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 866
neXtProt AC: NX_P08185

Human Synonyms: CBG

Human Chr (Location): 14q32.1; chr14:94304248-94323351 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINA6

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine.
 
Human Diseases Modeled in Mice Using Serpina6 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Serpina6 interacts with 44 markers (Mir7-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (60)    Tissues (5)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
Northern blot 24
cDNA source data(108)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(3) cDNA(108)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027668 (Evidence)
Ensembl Gene Model ENSMUSG00000060807 (Evidence)
Entrez Gene 12401 (Evidence)
UniGene 290079
DFCI TC1575276
DoTS DT.536139
NIA Mouse Gene Index U034298
Consensus CDS Project CCDS26135.1
International Mouse Phenotyping Consortium Status Serpina6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027668 VEGA Gene Model | MGI Sequence Detail 10583 C57BL/6J ±  kb
transcript OTTMUST00000068452 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000034618 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(150 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014686 corticosteroid-binding globulin
References
(Earliest) J:3809 Scrocchi LA, et al., Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice. Endocrinology. 1993 Feb;132(2):903-9
(Latest) J:192931 Minni AM, et al., Critical role of plasma corticosteroid-binding-globulin during stress to promote glucocorticoid delivery to the brain: impact on memory retrieval. Endocrinology. 2012 Oct;153(10):4766-74
All references(40)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1778, MGI:2144779, MGI:2144981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory