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Serpina6 Gene Detail
Summary
  • Symbol
    Serpina6
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 6
  • Synonyms
    Cbg
  • Feature Type
    protein coding gene
  • IDs
    MGI:88278
    NCBI Gene: 12401
  • Gene Overview
    MyGene.info: SERPINA6
Location & Maps
more
  • Sequence Map
    Chr12:103646630-103657212 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10583 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SERPINA6, serpin family A member 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SERPINA6, serpin family A member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CBG
  • Links
    NCBI Gene ID: 866
    neXtProt AC: NX_P08185

  • Chr Location
    14q32.1; chr14:94304248-94323351 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Serpina6 mouse models; 1 with human SERPINA6 associations

Human Disease Mouse Models
       Corticosteroid-Binding Globulin Deficiency   OMIM: 611489 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Serpina6
  • Incidental Mutations
Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027668 VEGA Gene Model | MGI Sequence Detail 10583 C57BL/6J ±  kb
transcript OTTMUST00000068452 VEGA | MGI Sequence Detail 1605 Not Applicable  
polypeptide OTTMUSP00000034618 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 111
    Genomic 3
    cDNA 108

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1778, MGI:2144779, MGI:2144981
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Diseases 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:3809 Scrocchi LA, et al., Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice. Endocrinology. 1993 Feb;132(2):903-9
  • Latest
    J:192931 Minni AM, et al., Critical role of plasma corticosteroid-binding-globulin during stress to promote glucocorticoid delivery to the brain: impact on memory retrieval. Endocrinology. 2012 Oct;153(10):4766-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory