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Cat Gene Detail
Summary
  • Symbol
    Cat
  • Name
    catalase
  • Synonyms
    Cas1, Cas-1, Cs-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88271
    NCBI Gene: 12359
  • Gene Overview
    MyGene.info: CAT
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103453904-103485153 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88271
protein coding gene Chr2:103453849-103485160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026204
protein coding gene Chr2:105436737-105467757 (-)
A/J MGP_AJ_G0026165
protein coding gene Chr2:101084558-101114958 (-)
AKR/J MGP_AKRJ_G0026146
protein coding gene Chr2:103826708-103858249 (-)
BALB/cJ MGP_BALBcJ_G0026174
protein coding gene Chr2:101371687-101402093 (-)
C3H/HeJ MGP_C3HHeJ_G0025925
protein coding gene Chr2:104176056-104207174 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026625
protein coding gene Chr2:108976734-109007829 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024016
protein coding gene Chr2:96764666-96800469 (-)
CAST/EiJ MGP_CASTEiJ_G0025390
protein coding gene Chr2:104649299-104681135 (-)
CBA/J MGP_CBAJ_G0025903
protein coding gene Chr2:112702268-112734801 (-)
DBA/2J MGP_DBA2J_G0026039
protein coding gene Chr2:100650271-100680457 (-)
FVB/NJ MGP_FVBNJ_G0026002
protein coding gene Chr2:99651283-99682379 (-)
LP/J MGP_LPJ_G0026143
protein coding gene Chr2:105571710-105602987 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026028
protein coding gene Chr2:116625833-116657059 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026679
protein coding gene Chr2:104043231-104074305 (-)
PWK/PhJ MGP_PWKPhJ_G0025125
protein coding gene Chr2:100161252-100193996 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024926
protein coding gene Chr2:103263734-103294909 (-)
WSB/EiJ MGP_WSBEiJ_G0025457
protein coding gene Chr2:104749410-104781314 (-)



Homology
more
  • Human Ortholog
    CAT, catalase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAT, catalase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 847
    neXtProt AC: NX_P04040
    UniProt: P04040

  • Chr Location
    11p13; chr11:34438925-34472060 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CAT associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 6 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12359 NCBI Gene Model | MGI Sequence Detail 31250 C57BL/6J ±  kb
    transcript NM_009804 RefSeq | MGI Sequence Detail 2551 C57BL/6  
    polypeptide P24270 UniProt | EBI | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 353
      Genomic 35
      cDNA 315
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 16
      Diseases 3
      Gene Ontology 26
      Phenotypes 53
    • Earliest
      J:5015 Feinstein RN, et al., Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966 May;53(5):923-33
    • Latest
      J:263791 Johnson JM, et al., Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome. J Mol Cell Cardiol. 2018 Jul 2;121:94-102

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory