Cat
Gene Detail

Symbol Name ID

Cat catalase MGI:88271

Synonyms

Cas1, Cas-1, Cs-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

54.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)

Sequence Map

Chr2:103453849-103485160 bp, - strand From VEGA annotation of GRCm38   31312 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Catalase_clade1-3
Gene Tree: Cat

Human homologs

Human Homolog		CAT, catalase
NCBI Gene ID		847
neXtProt AC		NX_P04040
Human Chr (Location)		11p13; chr11:34460472-34493607 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CAT

Alleles and phenotypes

All alleles(8) : Targeted(1) Gene trapped(1) Radiation induced(5) Other(1)
 

Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.

 

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	aerobic respiration, cholesterol metabolic process, ...
Component	cytosol, endoplasmic reticulum, ...
Function	aminoacylase activity, antioxidant activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (109)    Tissues (101)    Images (11)
Theiler Stages: 4, 22, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	94
Western blot	6
RT-PCR	7

cDNA source data(306)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(348) Genomic(35) cDNA(311) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014875 (Evidence)
Ensembl Gene Model	ENSMUSG00000027187 (Evidence)
Entrez Gene	12359 (Evidence)
UniGene	4215
DFCI	TC1577923, TC1635154
DoTS	DT.101198673, DT.87073214
NIA Mouse Gene Index	U023085
EC	1.11.1.6
Consensus CDS Project	CCDS16478.1
International Mouse Knockout Project Status	Cat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014875	VEGA Gene Model | MGI Sequence Detail	31312	C57BL/6J
transcript	OTTMUST00000035344	VEGA | MGI Sequence Detail	2613	Not Applicable
polypeptide	OTTMUSP00000015802	VEGA | MGI Sequence Detail	527	Not Applicable

All sequences(51) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(6) : SNPs(204 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024708	Catalase active site
InterPro	IPR011614	Catalase core domain
InterPro	IPR002226	Catalase haem-binding site
InterPro	IPR010582	Catalase immune-responsive domain
InterPro	IPR020835	Catalase-like domain
InterPro	IPR018028	Catalase, mono-functional, haem-containing
InterPro	IPR024711	Catalase, mono-functional, haem-containing, clades 1 and 3
Protein Ontology	PR:000005061	catalase

References

(Earliest) J:5015 Feinstein RN, et al., Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966 May;53(5):923-33
(Latest) J:187697 Sasaki M, et al., D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012 Sep 15;26(18):2038-49
All references(127)

Other accession IDs

MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185