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Cat
Gene Detail
Symbol

Name
ID
Cat
catalase
MGI:88271
Synonyms
Cas1, Cas-1, Cs-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr2:103453849-103485160 bp, - strand
From VEGA annotation of GRCm38

  31312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: Catalase_clade1-3
Gene Tree: Cat

Human
homologs
Human Homolog CAT, catalase
NCBI Gene ID 847
neXtProt AC  NX_P04040
Human Chr (Location)  11p13; chr11:34438925-34472060 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Radiation induced(5) Targeted(1)
 
Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.
 
Interactions
Cat interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process aerobic respiration, cholesterol metabolic process, ...
Component cytosol, endoplasmic reticulum, ...
Function aminoacylase activity, antioxidant activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (108)    Tissues (101)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 94
Western blot 6
RT-PCR 6
cDNA source data(308)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(350) Genomic(35) cDNA(313) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014875 (Evidence)
Ensembl Gene ModelENSMUSG00000027187 (Evidence)
Entrez Gene12359 (Evidence)
UniGene4215
DFCITC1577923, TC1635154
DoTSDT.101198673, DT.87073214
NIA Mouse Gene IndexU023085
EC1.11.1.6
Consensus CDS ProjectCCDS16478.1
International Mouse Knockout Project StatusCat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014875 VEGA Gene Model | MGI Sequence Detail 31312 C57BL/6J ±  kb
transcript OTTMUST00000035344 VEGA | MGI Sequence Detail 2613 Not Applicable 
polypeptide OTTMUSP00000015802 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(15)
Polymorphisms
RFLP(6) : SNPs within 2kb(311 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024708 Catalase active site
InterPro IPR011614 Catalase core domain
InterPro IPR002226 Catalase haem-binding site
InterPro IPR010582 Catalase immune-responsive domain
InterPro IPR020835 Catalase-like domain
InterPro IPR018028 Catalase, mono-functional, haem-containing
InterPro IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3
Protein Ontology PR:000005061 catalase
References
(Earliest) J:5015 Feinstein RN, et al., Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966 May;53(5):923-33
(Latest) J:207588 Miller L, et al., Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice. Toxicol Sci. 2013 Aug;134(2):400-11
All references(130)
Other
accession IDs
MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory