About   Help   FAQ
Cat
Gene Detail
Symbol

Name
ID
Cat
catalase
MGI:88271
Synonyms
Cas1, Cas-1, Cs-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr2:103453849-103485160 bp, - strand
From VEGA annotation of GRCm38

  31312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: CAT
Protein SuperFamily: Catalase_clade1-3
Gene Tree: Cat

Human
homologs
CAT, catalase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 847
neXtProt AC: NX_P04040

Human Chr (Location): 11p13; chr11:34438925-34472060 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Radiation induced(5) Targeted(1) Transgenic(2)
 
Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Cat interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process aerobic respiration, cholesterol metabolic process, ...
Component cytosol, endoplasmic reticulum, ...
Function aminoacylase activity, antioxidant activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (108)    Tissues (101)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 94
Western blot 6
RT-PCR 6
cDNA source data(308)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cat.1, cat.2 ; ZFIN cat    NEW 
Molecular
reagents
All nucleic(350) Genomic(35) cDNA(313) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014875 (Evidence)
Ensembl Gene Model ENSMUSG00000027187 (Evidence)
Entrez Gene 12359 (Evidence)
UniGene 4215
DFCI TC1577923, TC1635154
DoTS DT.101198673, DT.87073214
NIA Mouse Gene Index U023085
EC 1.11.1.6
Consensus CDS Project CCDS16478.1
International Mouse Phenotyping Consortium Status Cat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014875 VEGA Gene Model | MGI Sequence Detail 31312 C57BL/6J ±  kb
transcript OTTMUST00000035344 VEGA | MGI Sequence Detail 2613 Not Applicable 
polypeptide OTTMUSP00000015802 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(8)
Polymorphisms
RFLP(6) : SNPs within 2kb(311 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024708 Catalase active site
InterPro IPR011614 Catalase core domain
InterPro IPR002226 Catalase haem-binding site
InterPro IPR010582 Catalase immune-responsive domain
InterPro IPR020835 Catalase-like domain
InterPro IPR018028 Catalase, mono-functional, haem-containing
InterPro IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3
Protein Ontology PR:000005061 catalase
References
(Earliest) J:5015 Feinstein RN, et al., Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966 May;53(5):923-33
(Latest) J:215197 Kim HR, et al., Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function. PLoS One. 2014;9(4):e95332
All references(126)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory