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Cat Gene Detail
Summary
  • Symbol
    Cat
  • Name
    catalase
  • Synonyms
    Cas1, Cas-1, Cs-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88271
    NCBI Gene: 12359
  • Gene Overview
    MyGene.info: CAT
Location & Maps
more
  • Sequence Map
    Chr2:103453849-103485160 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31312 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    34 experiments
Homology
more
  • Human Ortholog
    CAT, catalase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAT, catalase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 847
    neXtProt AC: NX_P04040

  • Chr Location
    11p13; chr11:34438925-34472060 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cat mouse models; 1 with human CAT associations

Human Disease Mouse Models
       Acatalasemia   OMIM: 614097 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    6
  • Targeted
    1
  • Transgenic
    2
  • Genomic Mutations
    2 involving Cat
Mice homozygous for disruptions in this gene display a generally normal phenotype although subtle abnormalities do occur in mitochondrial respiration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014875 VEGA Gene Model | MGI Sequence Detail 31312 C57BL/6J ±  kb
transcript OTTMUST00000035344 VEGA | MGI Sequence Detail 2613 Not Applicable  
polypeptide OTTMUSP00000015802 VEGA | MGI Sequence Detail 527 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    313 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 351
    Genomic 35
    cDNA 313
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1765, MGD-MRK-1766, MGD-MRK-2185
References
more
  • Summaries
    All 129
    Developmental Gene Expression 14
    Diseases 3
    Gene Ontology 25
    Phenotypes 44
  • Earliest
    J:5015 Feinstein RN, et al., Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966 May;53(5):923-33
  • Latest
    J:234224 Liang L, et al., Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKbeta-AMPK-dependent regulation of autophagy. Biochim Biophys Acta. 2015 Feb;1852(2):343-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory