Car8
Gene Detail

Symbol Name ID

Car8 carbonic anhydrase 8 MGI:88253

Synonyms

Cals1, Carp, CA-RP VIII, wdl

Feature Type

protein coding gene

Genetic Map

Chromosome 4

3.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:8143367-8239041 bp, - strand From VEGA annotation of GRCm38   95675 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car8

Human homologs

Human Homolog		CA8, carbonic anhydrase VIII
NCBI Gene ID		767
neXtProt AC		NX_P35219
Human Synonyms		CALS, CAMRQ3, CARP, CA-VIII
Human Chr (Location)		8q12.1; chr8:61101423-61193954 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CA8

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Spontaneous(1)
 

Mice homozygous for a spontaneous deletion exhibit a wobbly side-to-side gait which is first noted at two weeks of age and persists throughout life.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	one-carbon metabolic process, phosphatidylinositol-mediated signaling
Component	cytoplasm
Function	carbonate dehydratase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (254)    Tissues (138)    Images (64)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	254

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000004323 (Evidence)
Ensembl Gene Model	ENSMUSG00000041261 (Evidence)
Entrez Gene	12319 (Evidence)
DFCI	TC1580658, TC1596317, TC1712128
DoTS	DT.102529759, DT.529972
NIA Mouse Gene Index	U024827
Consensus CDS Project	CCDS17954.1
International Mouse Knockout Project Status	Car8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004323	VEGA Gene Model | MGI Sequence Detail	95675	C57BL/6J
transcript	OTTMUST00000009792	VEGA | MGI Sequence Detail	3848	Not Applicable
polypeptide	OTTMUSP00000004709	VEGA | MGI Sequence Detail	291	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(727 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR023561	Carbonic anhydrase, alpha-class
InterPro	IPR018338	Carbonic anhydrase, alpha-class, conserved site
InterPro	IPR018434	Carbonic anhydrase-related protein, CA-VIII
Protein Ontology	PR:000004925	carbonic anhydrase-related protein

References

(Earliest) J:15409 Kato K, Sequence of a novel carbonic anhydrase-related polypeptide and its exclusive presence in Purkinje cells. FEBS Lett. 1990 Oct 1;271(1-2):137-40
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(44)

Other accession IDs

MGD-MRK-1740, MGD-MRK-19364, MGI:2140591, MGI:2449027