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Car8
Gene Detail
Symbol

Name
ID
Car8
carbonic anhydrase 8
MGI:88253
Synonyms
Cals1, Carp, CA-RP VIII, wdl
Feature Type
protein coding gene
Genetic Map
Chromosome 4
3.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:8143362-8239041 bp, - strand
From VEGA annotation of GRCm38

  95680 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CA8
Protein SuperFamily: carbonate dehydratase
Gene Tree: Car8

Human
homologs
CA8, carbonic anhydrase VIII
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 767
neXtProt AC: NX_P35219

Human Synonyms: CALS, CAMRQ3, CARP, CA-VIII

Human Chr (Location): 8q12.1; chr8:60187347-60281395 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CA8

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous deletion exhibit a wobbly side-to-side gait which is first noted at two weeks of age and persists throughout life.
 
Interactions
Car8 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process one-carbon metabolic process, phosphatidylinositol-mediated signaling
Component cytoplasm
Function carbonate dehydratase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (303)    Tissues (188)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 303
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ca8    NEW 
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000004323 (Evidence)
Ensembl Gene Model ENSMUSG00000041261 (Evidence)
Entrez Gene 12319 (Evidence)
DFCI TC1580658, TC1596317, TC1712128
DoTS DT.102529759, DT.529972
NIA Mouse Gene Index U024827
Consensus CDS Project CCDS17954.1
International Mouse Phenotyping Consortium Status Car8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004323 VEGA Gene Model | MGI Sequence Detail 95680 C57BL/6J ±  kb
transcript OTTMUST00000009792 VEGA | MGI Sequence Detail 3853 Not Applicable 
polypeptide OTTMUSP00000004709 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(929 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018434 Carbonic anhydrase-related protein, CA-VIII
Protein Ontology PR:000004925 carbonic anhydrase-related protein
References
(Earliest) J:15409 Kato K, Sequence of a novel carbonic anhydrase-related polypeptide and its exclusive presence in Purkinje cells. FEBS Lett. 1990 Oct 1;271(1-2):137-40
(Latest) J:208769 Nakatani T, et al., The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. 2014 Apr 1;388(1):68-80
All references(44)
Other
accession IDs
MGD-MRK-1740, MGD-MRK-19364, MGI:2140591, MGI:2449027

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory