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C8b
Gene Detail
Symbol

Name
ID
C8b
complement component 8, beta polypeptide
MGI:88236
Synonyms
4930439B20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
48.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:104766317-104804548 bp, + strand
From VEGA annotation of GRCm38

  38232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: C8b

Human
homologs
Human Homolog C8B, complement component 8, beta polypeptide
NCBI Gene ID 732
neXtProt AC  NX_P07358
Human Synonyms  C82
Human Chr (Location)  1p32.2; chr1:56929210-56968277 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human C8B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
In a controlled microbial environment ("clean") laboratory, mice homozygous for an inactivating mutation of this gene are viable and fertile and exhibit no apparent abonormal phenotype.
 
Interactions
C8b interacts with 114 markers (Mir7-1, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process complement activation, alternative pathway, complement activation, classical pathway, ...
Component extracellular region, extracellular space, ...
Function protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008115 (Evidence)
Ensembl Gene ModelENSMUSG00000029656 (Evidence)
Entrez Gene110382 (Evidence)
UniGene87072
DFCITC1584017, TC1628964
DoTSDT.484738, DT.524848, DT.99852091
NIA Mouse Gene IndexU004574
Consensus CDS ProjectCCDS18414.1
International Mouse Knockout Project StatusC8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008115 VEGA Gene Model | MGI Sequence Detail 38232 C57BL/6J ±  kb
transcript OTTMUST00000018444 VEGA | MGI Sequence Detail 2239 Not Applicable 
polypeptide OTTMUSP00000008473 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001862 Membrane attack complex component/perforin/complement C9
InterPro IPR020863 Membrane attack complex component/perforin domain, conserved site
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000004909 complement component C8 beta chain
References
(Earliest) J:3321 Bahary N, et al., Molecular genetic linkage maps of mouse chromosomes 4 and 6. Genomics. 1991 Sep;11(1):33-47
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-1714, MGI:1921221, MGI:2140338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory