C8b
Gene Detail

Symbol Name ID

C8b complement component 8, beta polypeptide MGI:88236

Synonyms

4930439B20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

48.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr4:104766317-104804548 bp, + strand From VEGA annotation of GRCm38   38232 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: C8b

Human homologs

Human Homolog		C8B, complement component 8, beta polypeptide
NCBI Gene ID		732
neXtProt AC		NX_P07358
Human Chr (Location)		1p32; chr1:57394883-57431688 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human C8B

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

In a controlled microbial environment ("clean") laboratory, mice homozygous for an inactivating mutation of this gene are viable and fertile and exhibit no apparent abonormal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	complement activation, alternative pathway, complement activation, classical pathway, ...
Component	extracellular region, extracellular space, ...
Function	protein complex binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(20)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008115 (Evidence)
Ensembl Gene Model	ENSMUSG00000029656 (Evidence)
Entrez Gene	110382 (Evidence)
UniGene	87072
DFCI	TC1584017, TC1628964
DoTS	DT.484738, DT.524848, DT.99852091
NIA Mouse Gene Index	U004574
Consensus CDS Project	CCDS18414.1
International Mouse Knockout Project Status	C8b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008115	VEGA Gene Model | MGI Sequence Detail	38232	C57BL/6J
transcript	OTTMUST00000018444	VEGA | MGI Sequence Detail	2239	Not Applicable
polypeptide	OTTMUSP00000008473	VEGA | MGI Sequence Detail	589	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(206 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR001862	Membrane attack complex component/perforin/complement C9
InterPro	IPR020863	Membrane attack complex component/perforin domain, conserved site
InterPro	IPR020864	Membrane attack complex component/perforin (MACPF) domain
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000004909	complement component C8 beta chain

References

(Earliest) J:3321 Bahary N, et al., Molecular genetic linkage maps of mouse chromosomes 4 and 6. Genomics. 1991 Sep;11(1):33-47
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGD-MRK-1714, MGI:1921221, MGI:2140338