C4b
Gene Detail

Symbol Name ID

C4b complement component 4B (Chido blood group) MGI:88228

STS

D17Mit34

Synonyms

C4, Ss

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr17:34728380-34743882 bp, - strand From VEGA annotation of GRCm38   15503 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36030  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: C4b

Human homologs

Human Homolog		C4A, complement component 4A (Rodgers blood group)
NCBI Gene ID		720
neXtProt AC		NX_P0C0L4
Human Synonyms		C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
Human Chr (Location)		6p21.3; chr6:31949834-31970457 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human C4A
Human Homolog		C4B, complement component 4B (Chido blood group)
NCBI Gene ID		721
neXtProt AC		NX_P0C0L5
Human Synonyms		C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3
Human Chr (Location)		6p21.3; chr6:31982572-32003195 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human C4B

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous C4 deficient mice have compromised immune responses.

 
Human Diseases Modeled Using Mouse C4b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	complement activation, immunoglobulin mediated immune response
Component	extracellular region, extracellular space

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (50)    Images (4)
Theiler Stages: 16, 18, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	25
RT-PCR	41

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(104) Genomic(71) cDNA(28) Primer pair(1) Other(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037255 (Evidence)
Ensembl Gene Model	ENSMUSG00000073418 (Evidence)
Entrez Gene	12268 (Evidence)
Consensus CDS Project	CCDS28657.1
International Mouse Knockout Project Status	C4b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037255	VEGA Gene Model | MGI Sequence Detail	15503	C57BL/6J
transcript	OTTMUST00000096077	VEGA | MGI Sequence Detail	5379	Not Applicable
polypeptide	OTTMUSP00000053641	VEGA | MGI Sequence Detail	1738	Not Applicable

All sequences(45) RefSeq(2)

Polymorphisms

RFLP(15) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000004902	complement C4-B

References

(Earliest) J:5011 Lilly F, The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529-39
(Latest) J:195307 Sponarova J, et al., Efficient amyloid a clearance in the absence of immunoglobulins and complement factors. Am J Pathol. 2013 Apr;182(4):1297-307
All references(157)

Other accession IDs

MGD-MRK-14605, MGD-MRK-1701