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C4b
Gene Detail
 Symbol
Name
ID
C4b
complement component 4B (Chido blood group)
MGI:88228
STS D17Mit34
Synonyms C4, Ss
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr17:34728380-34743882 bp, - strand
From VEGA annotation of GRCm38

  15503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36030  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: C4b

Human
homologs
Human Homolog C4A, complement component 4A (Rodgers blood group)
NCBI Gene ID 720
neXtProt AC  NX_P0C0L4
Human Synonyms  C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
Human Chr (Location)  6p21.3; chr6:31982057-32002680 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human C4A
Human Homolog C4B, complement component 4B (Chido blood group)
NCBI Gene ID 721
neXtProt AC  NX_P0C0L4, NX_P0C0L5
Human Synonyms  C4B1, C4B12, C4B2, C4B_2, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3
Human Chr (Location)  6p21.3; chr6:32014795-32035418 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C4B
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Homozygous C4 deficient mice have compromised immune responses.
 
Human Diseases Modeled Using Mouse C4b (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process complement activation, immunoglobulin mediated immune response
Component blood microparticle, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (50)    Images (4)
Theiler Stages: 16, 18, 20, 21, 23, 25, 28
Assay TypeResults
RNA in situ 25
RT-PCR 41
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(104) Genomic(71) cDNA(28) Primer pair(1) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037255 (Evidence)
Ensembl Gene ModelENSMUSG00000073418 (Evidence)
Entrez Gene12268 (Evidence)
Consensus CDS ProjectCCDS28657.1
International Mouse Knockout Project StatusC4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037255 VEGA Gene Model | MGI Sequence Detail 15503 C57BL/6J ±  kb
transcript OTTMUST00000096077 VEGA | MGI Sequence Detail 5379 Not Applicable 
polypeptide OTTMUSP00000053641 VEGA | MGI Sequence Detail 1738 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(16)
Polymorphisms RFLP(15) : SNPs within 2kb(223 from dbSNP Build 137)    SNPs within 2kb including multiple locations(407)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000004902 complement C4-B
References (Earliest) J:5011 Lilly F, The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529-39
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(161)
Other
accession IDs
MGD-MRK-14605, MGD-MRK-1701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory