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C4b
Gene Detail
Symbol

Name
ID
C4b
complement component 4B (Chido blood group)
MGI:88228
STS
Synonyms
C4, Ss
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr17:34728380-34743882 bp, - strand
From VEGA annotation of GRCm38

  15503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36030  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: C4A, C4B
Gene Tree: C4b

Human
homologs
C4A, complement component 4A (Rodgers blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 720
neXtProt AC: NX_P0C0L4

Human Synonyms: C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG

Human Chr (Location): 6p21.3; chr6:31982057-32002680 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human C4A

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous C4 deficient mice have compromised immune responses.
 
Human Diseases Modeled in Mice Using C4b (1)    Mutations Annotated to Human Diseases (1)   
Interactions
C4b interacts with 88 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process complement activation, immunoglobulin mediated immune response
Component blood microparticle, extracellular exosome, ...
Function carbohydrate binding, complement binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (54)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 41
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) Genomic(71) cDNA(28) Primer pair(1) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037255 (Evidence)
Ensembl Gene Model ENSMUSG00000073418 (Evidence)
Entrez Gene 12268 (Evidence)
Consensus CDS Project CCDS28657.1
International Mouse Phenotyping Consortium Status C4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037255 VEGA Gene Model | MGI Sequence Detail 15503 C57BL/6J ±  kb
transcript OTTMUST00000096077 VEGA | MGI Sequence Detail 5379 Not Applicable 
polypeptide OTTMUSP00000053641 VEGA | MGI Sequence Detail 1738 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(15)
Polymorphisms
RFLP(15) : SNPs within 2kb(223 from dbSNP Build 137)    SNPs within 2kb including multiple locations(407)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000004902 complement C4-B
References
(Earliest) J:5011 Lilly F, The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529-39
(Latest) J:223071 Cresci GA, et al., Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl(4)-induced injury. Mol Immunol. 2015 Mar;64(1):9-17
All references(157)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14605, MGD-MRK-1701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory