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C1qa
Gene Detail
Symbol

Name
ID
C1qa
complement component 1, q subcomponent, alpha polypeptide
MGI:88223
Synonyms
C1q
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:136895917-136898803 bp, - strand
From VEGA annotation of GRCm38

  2887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: C1QA
Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: C1qa

Human
homologs
C1QA, complement component 1, q subcomponent, A chain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 712
neXtProt AC: NX_P02745

Human Chr (Location): 1p36.12; chr1:22636625-22639682 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human C1QA

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving C1qa (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display absence seizures, glomerulonephritis, increased numbers of glomerular apoptotic bodies, high autoantibody titres, and increased mortality, with severity affected by genetic background.
 
Human Diseases Modeled in Mice Using C1qa (1)    Mutations Annotated to Human Diseases (1)   
Interactions
C1qa interacts with 41 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process complement activation, classical pathway, immune system process, ...
Component collagen trimer, extracellular exosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (19)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(121)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN c1qa    NEW 
Molecular
reagents
All nucleic(126) Genomic(5) cDNA(121)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009765 (Evidence)
Ensembl Gene Model ENSMUSG00000036887 (Evidence)
Entrez Gene 12259 (Evidence)
UniGene 439957
DFCI TC1574493
DoTS DT.101387343, DT.494330
NIA Mouse Gene Index U025674
Consensus CDS Project CCDS18812.1
International Mouse Phenotyping Consortium Status C1qa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009765 VEGA Gene Model | MGI Sequence Detail 2887 C57BL/6J ±  kb
transcript OTTMUST00000022609 VEGA | MGI Sequence Detail 1040 Not Applicable 
polypeptide OTTMUSP00000010321 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001073 C1q domain
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000004875 complement C1q subcomponent subunit A
References
(Earliest) J:1795 Petry F, et al., Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J Immunol. 1991 Dec 1;147(11):3988-93
(Latest) J:223071 Cresci GA, et al., Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl(4)-induced injury. Mol Immunol. 2015 Mar;64(1):9-17
All references(147)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1696, MGI:2140213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory