C1qa
Gene Detail

Symbol Name ID

C1qa complement component 1, q subcomponent, alpha polypeptide MGI:88223

Synonyms

C1q

Feature Type

protein coding gene

Genetic Map

Chromosome 4

69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr4:136895917-136898803 bp, - strand From VEGA annotation of GRCm38   2887 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: C1qa

Human homologs

Human Homolog		C1QA, complement component 1, q subcomponent, A chain
NCBI Gene ID		712
neXtProt AC		NX_P02745
Human Chr (Location)		1p36.12; chr1:22963118-22966175 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human C1QA

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele display absence seizures, glomerulonephritis, increased numbers of glomerular apoptotic bodies, high autoantibody titres, and increased mortality, with severity affected by genetic background.

 
Human Diseases Modeled Using Mouse C1qa (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	complement activation, classical pathway, innate immune response
Component	collagen, extracellular region
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (19)    Images (6)
Theiler Stages: 20, 21

Assay Type	Results
RNA in situ	24

cDNA source data(119)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) Genomic(5) cDNA(119)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009765 (Evidence)
Ensembl Gene Model	ENSMUSG00000036887 (Evidence)
Entrez Gene	12259 (Evidence)
UniGene	439957
DFCI	TC1574493
DoTS	DT.101387343, DT.494330
NIA Mouse Gene Index	U025674
Consensus CDS Project	CCDS18812.1
International Mouse Knockout Project Status	C1qa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009765	VEGA Gene Model | MGI Sequence Detail	2887	C57BL/6J
transcript	OTTMUST00000022609	VEGA | MGI Sequence Detail	1040	Not Applicable
polypeptide	OTTMUSP00000010321	VEGA | MGI Sequence Detail	245	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR001073	Complement C1q protein
InterPro	IPR008983	Tumour necrosis factor-like
Protein Ontology	PR:000004875	complement C1q subcomponent subunit A

References

(Earliest) J:1795 Petry F, et al., Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J Immunol. 1991 Dec 1;147(11):3988-93
(Latest) J:190597 Elvington A, et al., The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 1;189(9):4640-7
All references(128)

Other accession IDs

MGD-MRK-1696, MGI:2140213