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C1qa Gene Detail
Summary
  • Symbol
    C1qa
  • Name
    complement component 1, q subcomponent, alpha polypeptide
  • Synonyms
    C1q
  • Feature Type
    protein coding gene
  • IDs
    MGI:88223
    NCBI Gene: 12259
  • Gene Overview
    MyGene.info: C1QA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136895917-136898803 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.05 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88223
protein coding gene Chr4:136895916-136898844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028975
protein coding gene Chr4:139488898-139491784 (-)
A/J MGP_AJ_G0028934
protein coding gene Chr4:133553990-133556782 (-)
AKR/J MGP_AKRJ_G0028886
protein coding gene Chr4:137399324-137402116 (-)
BALB/cJ MGP_BALBcJ_G0028958
protein coding gene Chr4:134218373-134221259 (-)
C3H/HeJ MGP_C3HHeJ_G0028672
protein coding gene Chr4:137695676-137698562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029399
protein coding gene Chr4:144466891-144469777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026670
protein coding gene Chr4:126580754-126583592 (-)
CAST/EiJ MGP_CASTEiJ_G0028104
protein coding gene Chr4:135845554-135848357 (-)
CBA/J MGP_CBAJ_G0028637
protein coding gene Chr4:148458790-148461676 (-)
DBA/2J MGP_DBA2J_G0028786
protein coding gene Chr4:133957564-133960450 (-)
FVB/NJ MGP_FVBNJ_G0028753
protein coding gene Chr4:132917456-132920342 (-)
LP/J MGP_LPJ_G0028885
protein coding gene Chr4:139575396-139578282 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028779
protein coding gene Chr4:152596503-152599389 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029437
protein coding gene Chr4:137880074-137882960 (-)
PWK/PhJ MGP_PWKPhJ_G0027824
protein coding gene Chr4:130750086-130752878 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027650
protein coding gene Chr4:133671764-133674654 (-)
WSB/EiJ MGP_WSBEiJ_G0028182
protein coding gene Chr4:138038690-138041482 (-)



Homology
more
  • Human Ortholog
    C1QA, complement C1q A chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C1QA, complement C1q A chain
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 712
    neXtProt AC: NX_P02745
    UniProt: P02745

  • Chr Location
    1p36.12; chr1:22636625-22639682 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with C1qa mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display absence seizures, glomerulonephritis, increased numbers of glomerular apoptotic bodies, high autoantibody titres, and increased mortality, with severity affected by genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036887 Ensembl Gene Model | MGI Sequence Detail 2887 C57BL/6J ±  kb
    transcript ENSMUST00000046285 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    polypeptide ENSMUSP00000048836 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 5
      cDNA 122

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1696, MGI:2140213
    References
    more
    • Summaries
      All 175
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 4
      Phenotypes 127
    • Earliest
      J:1795 Petry F, et al., Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J Immunol. 1991 Dec 1;147(11):3988-93
    • Latest
      J:263219 Ling GS, et al., C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism. Science. 2018 May 4;360(6388):558-563

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory