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C1qa
Gene Detail
 Symbol
Name
ID
C1qa
complement component 1, q subcomponent, alpha polypeptide
MGI:88223
Synonyms C1q
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:136895917-136898803 bp, - strand
From VEGA annotation of GRCm38

  2887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: C1qa

Human
homologs
Human Homolog C1QA, complement component 1, q subcomponent, A chain
NCBI Gene ID 712
neXtProt AC  NX_P02745
Human Chr (Location)  1p36.12; chr1:22636625-22639682 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C1QA
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display absence seizures, glomerulonephritis, increased numbers of glomerular apoptotic bodies, high autoantibody titres, and increased mortality, with severity affected by genetic background.
 
Human Diseases Modeled Using Mouse C1qa (1)    Alleles Annotated to Human Diseases(1)   
Interactions
C1qa interacts with 41 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process complement activation, classical pathway, immune system process, ...
Component collagen trimer, extracellular region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (19)    Images (6)
Theiler Stages: 20, 21
Assay TypeResults
RNA in situ 24
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(126) Genomic(5) cDNA(121)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009765 (Evidence)
Ensembl Gene ModelENSMUSG00000036887 (Evidence)
Entrez Gene12259 (Evidence)
UniGene439957
DFCITC1574493
DoTSDT.101387343, DT.494330
NIA Mouse Gene IndexU025674
Consensus CDS ProjectCCDS18812.1
International Mouse Knockout Project StatusC1qa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009765 VEGA Gene Model | MGI Sequence Detail 2887 C57BL/6J ±  kb
transcript OTTMUST00000022609 VEGA | MGI Sequence Detail 1040 Not Applicable 
polypeptide OTTMUSP00000010321 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001073 Complement C1q protein
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000004875 complement C1q subcomponent subunit A
References (Earliest) J:1795 Petry F, et al., Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J Immunol. 1991 Dec 1;147(11):3988-93
(Latest) J:207387 Bossi F, et al., C1q as a unique player in angiogenesis with therapeutic implication in wound healing. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4209-14
All references(141)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1696, MGI:2140213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory