C1qa Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

C1qa
complement component 1, q subcomponent, alpha polypeptide
MGI:88223

20 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
C1qa^tm1.1Tenn/C1qa^tm1.1Tenn either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * FVB/N)	no abnormal phenotype detected	J:136269
C1qa^{tm1b(EUCOMM)Wtsi}/C1qa^{tm1b(EUCOMM)Wtsi} B6N(Cg)-C1qa^{tm1b(EUCOMM)Wtsi}/3J	decreased blood urea nitrogen level	J:211773
	decreased circulating glucose level	J:211773
	increased circulating chloride level	J:211773
C1qa^tm1Mjw/C1qa^tm1Mjw involves: 129P2/Ola * 129S/SvEv	normal immune system phenotype	J:47315
C1qa^tm1Mjw/C1qa^tm1Mjw involves: 129P2/Ola * 129S/SvEv * C57BL/6	glomerular crescent	J:47315
	glomerulonephritis	J:47315
	increased anti-histone antibody level	J:47315
	increased anti-nuclear antigen antibody level	J:47315
	increased renal glomerulus apoptosis	J:47315
	increased susceptibility to bacterial infection	J:83712
	premature death	J:47315
C1qa^tm1Mjw/C1qa^tm1Mjw involves: 129S/SvEv	abnormal excitatory postsynaptic currents	J:159281
	abnormal hippocampus pyramidal cell morphology	J:159281
	abnormal inhibitory postsynaptic currents	J:159281
	abnormal synaptic bouton morphology	J:159281
	absence seizures	J:159281
	increased excitatory postsynaptic current frequency	J:159281
	increased miniature excitatory postsynaptic current frequency	J:159281
	seizures	J:159281

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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