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Bsg
Gene Detail
Symbol

Name
ID
Bsg
basigin
MGI:88208
Synonyms
5A11/Basigin, CD147, EMMPRIN, gp 42, HT-7, neurothelin
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:79704491-79711969 bp, + strand
From VEGA annotation of GRCm38

  7479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

HCOP human homology predictions: BSG
Protein SuperFamily: cell surface glycoprotein HT7
Gene Tree: Bsg

Human
homologs
BSG, basigin (Ok blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 682
neXtProt AC: NX_P35613

Human Synonyms: 5F7, CD147, EMMPRIN, M6, OK, TCSF

Human Chr (Location): 19p13.3; chr19:571277-583493 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Most homozygous null mutants die near the time of implantation. Half of the survivors die prior to 1 month of age from interstitial pneumonia. The remaining mice are small, sterile, have retinal abnormalities, and perform poorly in behavioral tests.
 
Interactions
Bsg interacts with 39 markers (Mir1a-1, Mir1a-2, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process protein targeting to plasma membrane
Component acrosomal membrane, extracellular exosome, ...
Function carbohydrate binding, mannose binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (205)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 175
Northern blot 13
RT-PCR 12
cDNA source data(494)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bsg ; ZFIN bsg    NEW 
Molecular
reagents
All nucleic(501) Genomic(3) cDNA(494) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000042290 (Evidence)
Ensembl Gene Model ENSMUSG00000023175 (Evidence)
Entrez Gene 12215 (Evidence)
UniGene 726
DFCI TC1573844, TC1586331
DoTS DT.101165451, DT.101361365, DT.101361655, DT.101361743, DT.103586418, DT.110628685, DT.110628768, DT.110628911, DT.110628916, DT.110629031, DT.110629784, DT.110629862, DT.496444, DT.91569286, DT.97415679, DT.97415682
NIA Mouse Gene Index U011720
Consensus CDS Project CCDS23985.1, CCDS35967.1
International Mouse Phenotyping Consortium Status Bsg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042290 VEGA Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
transcript OTTMUST00000111260 VEGA | MGI Sequence Detail 1526 Not Applicable 
polypeptide OTTMUSP00000062228 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(5) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009151 Basigin
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000001324 basigin
References
(Earliest) J:10365 Altruda F, et al., Cloning of cDNA for a novel mouse membrane glycoprotein (gp42): shared identity to histocompatibility antigens, immunoglobulins and neural-cell adhesion molecules. Gene. 1989 Dec 28;85(2):445-51
(Latest) J:216233 Moreno V, et al., An EMMPRIN-gamma-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81
All references(81)
Other
accession IDs
MGD-MRK-1674, MGI:2143523, MGI:2143580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory