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Bsg Gene Detail
Summary
  • Symbol
    Bsg
  • Name
    basigin
  • Synonyms
    5A11/Basigin, CD147, EMMPRIN, gp 42, HT-7, neurothelin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88208
    NCBI Gene: 12215
  • Gene Overview
    MyGene.info: BSG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:79704491-79711969 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7479 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    BSG, basigin (Ok blood group)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BSG, basigin (Ok blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5F7, CD147, EMMPRIN, EMPRIN, OK, TCSF
  • Links
    NCBI Gene ID: 682
    neXtProt AC: NX_P35613
    UniProt: P35613

  • Chr Location
    19p13.3; chr19:571277-583493 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most homozygous null mutants die near the time of implantation. Half of the survivors die prior to 1 month of age from interstitial pneumonia. The remaining mice are small, sterile, have retinal abnormalities, and perform poorly in behavioral tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042290 VEGA Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
    transcript OTTMUST00000111260 VEGA | MGI Sequence Detail 1526 Not Applicable  
    polypeptide OTTMUSP00000062228 VEGA | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      31 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 505
      Genomic 3
      cDNA 494
      Primer pair 6
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1674, MGI:2143523, MGI:2143580
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 14
      Gene Ontology 5
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256134 Schmidt N, et al., Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca(2+)-ATPases and Key Regulators of Ca(2+) Clearance. Neuron. 2017 Nov 15;96(4):827-838.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory