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Bsg
Gene Detail
Symbol

Name
ID
Bsg
basigin
MGI:88208
Synonyms
5A11/Basigin, CD147, EMMPRIN, gp 42, HT-7, neurothelin
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:79704491-79711969 bp, + strand
From VEGA annotation of GRCm38

  7479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: cell surface glycoprotein HT7
Gene Tree: Bsg

Human
homologs
Human Homolog BSG, basigin (Ok blood group)
NCBI Gene ID 682
neXtProt AC  NX_P35613
Human Synonyms  5F7, CD147, EMMPRIN, M6, OK, TCSF
Human Chr (Location)  19p13.3; chr19:571277-583493 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous null mutants die near the time of implantation. Half of the survivors die prior to 1 month of age from interstitial pneumonia. The remaining mice are small, sterile, have retinal abnormalities, and perform poorly in behavioral tests.
 
Interactions
Bsg interacts with 39 markers (Mir1a-1, Mir1a-2, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process protein targeting to plasma membrane
Component acrosomal membrane, extracellular vesicular exosome, ...
Function carbohydrate binding, mannose binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (205)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 175
Northern blot 13
RT-PCR 12
cDNA source data(494)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(501) Genomic(3) cDNA(494) Primer pair(4)
Microarray probesets(2)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042290 VEGA Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
transcript OTTMUST00000111260 VEGA | MGI Sequence Detail 1526 Not Applicable 
polypeptide OTTMUSP00000062228 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(5) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009151 Basigin
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000001324 basigin
References
(Earliest) J:10365 Altruda F, et al., Cloning of cDNA for a novel mouse membrane glycoprotein (gp42): shared identity to histocompatibility antigens, immunoglobulins and neural-cell adhesion molecules. Gene. 1989 Dec 28;85(2):445-51
(Latest) J:211382 Pablo KA, et al., Deletion of the Basigin gene results in reduced mitochondria in the neural retina. Biochem Biophys Res Commun. 2013 Aug 30;438(3):546-50
All references(81)
Other
accession IDs
MGD-MRK-1674, MGI:2143523, MGI:2143580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory