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Bcr
Gene Detail
Symbol

Name
ID
Bcr
breakpoint cluster region
MGI:88141
Synonyms
5133400C09Rik, mKIAA3017
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr10:75060896-75184923 bp, + strand
From Ensembl annotation of GRCm38

  124028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BCR
Gene Tree: Bcr

Human
homologs
BCR, breakpoint cluster region
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 613
neXtProt AC: NX_P11274

Human Synonyms: ALL, BCR1, CML, D22S11, D22S662, PHL

Human Chr (Location): 22q11.23; chr22:23180365-23318037 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BCR

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(8) Targeted(3) Transgenic(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.
 
Mutations Annotated to Human Diseases (6)   
Interactions
Bcr interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process actin cytoskeleton organization, brain development, ...
Component cell junction, cytoplasm, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (43)    Tissues (34)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
RT-PCR 32
cDNA source data(124)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BCR ; Xenbase bcr    NEW 
Molecular
reagents
All nucleic(129) Genomic(1) cDNA(125) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000009681 (Evidence)
Entrez Gene 110279 (Evidence)
UniGene 333722
DFCI TC1597717, TC1635563, TC1684238
DoTS DT.110596752, DT.50316472, DT.99841283
NIA Mouse Gene Index U011655
EC 2.7.11.1
Consensus CDS Project CCDS35935.1
International Mouse Phenotyping Consortium Status Bcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009681 Ensembl Gene Model | MGI Sequence Detail 124028 C57BL/6J ±  kb
transcript ENSMUST00000164107 Ensembl | MGI Sequence Detail 6537 Not Applicable 
polypeptide ENSMUSP00000126377 Ensembl | MGI Sequence Detail 1270 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(7) UniProt(3)
Polymorphisms
RFLP(13) : SNPs within 2kb(570 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015123 Bcr-Abl oncoprotein oligomerisation
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004712 breakpoint cluster region protein
References
(Earliest) J:31014 Heisterkamp N, et al., Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988 Aug 25;16(16):8045-56
(Latest) J:216285 Gray EJ, et al., Src Homology 2 Domain Containing Protein 5 (SH2D5) Binds the Breakpoint Cluster Region Protein, BCR, and Regulates Levels of Rac1-GTP. J Biol Chem. 2014 Dec 19;289(51):35397-408
All references(85)
Other
accession IDs
MGD-MRK-1530, MGI:1918508, MGI:2143646, MGI:2143694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory