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Bcr
Gene Detail
Symbol

Name
ID
Bcr
breakpoint cluster region
MGI:88141
Synonyms
5133400C09Rik, mKIAA3017
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr10:75060896-75184923 bp, + strand
From Ensembl annotation of GRCm38

  124028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcr

Human
homologs
Human Homolog BCR, breakpoint cluster region
NCBI Gene ID 613
neXtProt AC  NX_P11274
Human Synonyms  ALL, BCR1, CML, D22S11, D22S662, PHL
Human Chr (Location)  22q11.23; chr22:23180365-23318037 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human BCR
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.
 
Interactions
Bcr interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process actin cytoskeleton organization, brain development, ...
Component cytoplasm, cytosol, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (43)    Tissues (34)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
RT-PCR 32
cDNA source data(124)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(129) Genomic(1) cDNA(125) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000009681 (Evidence)
Entrez Gene110279 (Evidence)
UniGene333722
DFCITC1597717, TC1635563, TC1684238
DoTSDT.110596752, DT.50316472, DT.99841283
NIA Mouse Gene IndexU011655
EC2.7.11.1
Consensus CDS ProjectCCDS35935.1
International Mouse Knockout Project StatusBcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009681 Ensembl Gene Model | MGI Sequence Detail 124028 C57BL/6J ±  kb
transcript ENSMUST00000164107 Ensembl | MGI Sequence Detail 6537 Not Applicable 
polypeptide ENSMUSP00000126377 Ensembl | MGI Sequence Detail 1270 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(7) UniProt(5)
Polymorphisms
RFLP(13) : SNPs within 2kb(570 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015123 Bcr-Abl oncoprotein oligomerisation
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004712 breakpoint cluster region protein
References
(Earliest) J:31014 Heisterkamp N, et al., Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988 Aug 25;16(16):8045-56
(Latest) J:213862 Um K, et al., Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23;29(6):701-15
All references(85)
Other
accession IDs
MGD-MRK-1530, MGI:1918508, MGI:2143646, MGI:2143694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory