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Bcr Gene Detail
Summary
  • Symbol
    Bcr
  • Name
    breakpoint cluster region
  • Synonyms
    5133400C09Rik, mKIAA3017
  • Feature Type
    protein coding gene
  • IDs
    MGI:88141
    NCBI Gene: 110279
  • Gene Overview
    MyGene.info: BCR
Location & Maps
more
  • Sequence Map
    Chr10:75060896-75184923 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      124028 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.49 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    BCR, BCR, RhoGEF and GTPase activating protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCR, BCR, RhoGEF and GTPase activating protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALL, BCR1, CML, D22S11, D22S662, PHL
  • Links
    NCBI Gene ID: 613
    neXtProt AC: NX_P11274
    UniProt: P11274

  • Chr Location
    22q11.23; chr22:23180365-23318037 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3192
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BCR
  • Gene Tree
    Bcr
Human Diseases
more
  • Diseases
    2 with human BCR associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 12 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 5 genetic backgrounds
    70 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110279 NCBI Gene Model | MGI Sequence Detail 124028 C57BL/6J ±  kb
transcript NM_001081412 RefSeq | MGI Sequence Detail 6537 Not Specified  
polypeptide Q6PAJ1 UniProt | EBI | MGI Sequence Detail 1270 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    570 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 129
    Genomic 1
    cDNA 125
    Primer pair 1
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-1530, MGI:1918508, MGI:2143646, MGI:2143694
References
more
  • Summaries
    All 138
    Developmental Gene Expression 5
    Diseases 9
    Gene Ontology 14
    Phenotypes 77
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237378 Zhang B, et al., Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells. Blood. 2016 Dec 08;128(23):2671-2682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory