Bcr
Gene Detail

Symbol Name ID

Bcr breakpoint cluster region MGI:88141

Synonyms

5133400C09Rik, mKIAA3017

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr10:75060896-75184923 bp, + strand From NCBI annotation of GRCm38   124028 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bcr

Human homologs

Human Homolog		BCR, breakpoint cluster region
NCBI Gene ID		613
neXtProt AC		NX_P11274
Human Synonyms		ALL, BCR1, CML, D22S11, D22S662, PHL
Human Chr (Location)		22q11.23; chr22:23522552-23660224 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human BCR

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)
 

Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin cytoskeleton organization, brain development, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (43)    Tissues (33)    Images (4)
Theiler Stages: 16, 17, 20, 22, 26, 28

Assay Type	Results
RNA in situ	11
RT-PCR	32

cDNA source data(123)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(128) Genomic(1) cDNA(124) Primer pair(1) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000009681 (Evidence)
Entrez Gene	110279 (Evidence)
UniGene	485801
DFCI	TC1597717, TC1635563, TC1684238
DoTS	DT.110596752, DT.50316472, DT.99841283
NIA Mouse Gene Index	U011655
EC	2.7.11.1
Consensus CDS Project	CCDS35935.1
International Mouse Knockout Project Status	Bcr

Sequences

Length	Strain/Species
genomic	110279	NCBI Gene Model | MGI Sequence Detail	124028	C57BL/6J
transcript	NM_001081412	RefSeq | MGI Sequence Detail	6537	Not Specified
polypeptide	Q6PAJ1	UniProt | EBI | MGI Sequence Detail	1270	Not Applicable

All sequences(28) RefSeq(3) UniProt(3)

Polymorphisms

RFLP(13) : SNPs(555 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015123	Bcr-Abl oncoprotein oligomerisation
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000004712	breakpoint cluster region protein

Graphical View of Protein Domain Structure

References

(Earliest) J:31014 Heisterkamp N, et al., Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988 Aug 25;16(16):8045-56
(Latest) J:195022 Yu M, et al., Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012;7(11):e49756
All references(80)

Other accession IDs

MGD-MRK-1530, MGI:1918508, MGI:2143646, MGI:2143694