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Bcl3
Gene Detail
 Symbol
Name
ID
Bcl3
B cell leukemia/lymphoma 3
MGI:88140
Synonyms Bcl-3
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:19808462-19822770 bp, - strand
From VEGA annotation of GRCm38

  14309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: B-cell lymphoma 3-encoded protein
Gene Tree: Bcl3

Human
homologs
Human Homolog BCL3, B-cell CLL/lymphoma 3
NCBI Gene ID 602
neXtProt AC  NX_P20749
Human Synonyms  BCL4, D19S37
Human Chr (Location)  19q13.1-q13.2; chr19:44742817-44760044 (+)  GRCh38
Alleles
and
phenotypes
All alleles(44) : Gene trapped(38) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice lacking functional copies of this gene exhibit defects of the immune system including disruption of the humoral immune response and abnormal spleen and Peyer's patch organogenesis. Mutant mice show increased susceptibility to pathogens.
 
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process antimicrobial humoral response, cellular response to DNA damage stimulus, ...
Component Bcl3-Bcl10 complex, Bcl3/NF-kappaB2 complex, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (57)    Images (4)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28
Assay TypeResults
RNA in situ 44
RT-PCR 15
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031375 (Evidence)
Ensembl Gene ModelENSMUSG00000053175 (Evidence)
Entrez Gene12051 (Evidence)
DFCITC1581689, TC1607712, TC1661054, TC1675185
DoTSDT.40147972, DT.484062, DT.91388794
NIA Mouse Gene IndexU028242
Consensus CDS ProjectCCDS20914.2
International Mouse Knockout Project StatusBcl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031375 VEGA Gene Model | MGI Sequence Detail 14309 C57BL/6J ±  kb
transcript OTTMUST00000077737 VEGA | MGI Sequence Detail 1850 Not Applicable 
polypeptide OTTMUSP00000041182 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000004699 B-cell lymphoma 3 protein
References (Earliest) J:742 Bhatia K, et al., Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes. Oncogene. 1991 Sep;6(9):1569-73
(Latest) J:200648 O'Carroll C, et al., Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse. Clin Exp Immunol. 2013 Aug;173(2):332-42
All references(74)
Other
accession IDs
MGD-MRK-1525, MGD-MRK-1528, MGI:2141858, MGI:2141992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory