Bcl2
Gene Detail

Symbol Name ID

Bcl2 B cell leukemia/lymphoma 2 MGI:88138

STS

D1Nds7

Synonyms

Bcl-2, C430015F12Rik, D830018M01Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

49.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)

Sequence Map

Chr1:106538178-106714274 bp, - strand From VEGA annotation of GRCm38   176097 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: apoptosis regulator, Bcl2 type
Gene Tree: Bcl2

Human homologs

Human Homolog		BCL2, B-cell CLL/lymphoma 2
NCBI Gene ID		596
neXtProt AC		NX_P10415
Human Synonyms		Bcl-2, PPP1R50
Human Chr (Location)		18q21.3; chr18:60790579-60986613 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BCL2

Alleles and phenotypes

All alleles(11) : Targeted(8) Gene trapped(2) Chemically induced(1)
 

Homozygous null mutants show pleiotropic abnormalities including small size, increased postnatal mortality, polycystic kidneys, apoptotic involution of thymus and spleen, graying in the second hair follicle cycle, and reduced numbers of motor, sympathetic and sensory neurons.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (216 annotations)

Process	actin filament organization, apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	BH3 domain binding, BH domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (76 records)
Data Summary: Results (419)    Tissues (188)    Images (12)
Theiler Stages: 1, 2, 3, 4, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	97
RNA in situ	61
Northern blot	31
Western blot	47
RT-PCR	159
RNase protection	5
Nuclease S1	19

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(15) cDNA(21) Primer pair(12) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000022128 (Evidence)
Ensembl Gene Model	ENSMUSG00000057329 (Evidence)
Entrez Gene	12043 (Evidence)
Consensus CDS Project	CCDS15209.1
International Mouse Knockout Project Status	Bcl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022128	VEGA Gene Model | MGI Sequence Detail	176097	C57BL/6J
transcript	OTTMUST00000052517	VEGA | MGI Sequence Detail	7191	Not Applicable
polypeptide	OTTMUSP00000024915	VEGA | MGI Sequence Detail	236	Not Applicable

All sequences(31) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(14) : PCR(8) RFLP(6) SNPs(870 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013278	Apoptosis regulator, Bcl-2
InterPro	IPR004725	Apoptosis regulator, Bcl-2/ BclX
InterPro	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro	IPR020731	Apoptosis regulator, Bcl-2, BH4 motif, conserved site
InterPro	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
InterPro	IPR002475	Bcl2-like
InterPro	IPR026298	Blc2 family
Protein Ontology	PR:000002307	apoptosis regulator Bcl-2

References

(Earliest) J:8659 Negrini M, et al., Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell. 1987 May 22;49(4):455-63
(Latest) J:190833 Guerrero AD, et al., Cleavage of Anti-Apoptotic Bcl-2 Family Members after TCR Stimulation Contributes to the Decision between T Cell Activation and Apoptosis. J Immunol. 2013 Jan 1;190(1):168-73
All references(424)

Other accession IDs

MGD-MRK-1524, MGD-MRK-1526, MGI:2138629, MGI:2442315, MGI:2444619, MGI:2444682