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Gene Detail
B cell leukemia/lymphoma 2
STS D1Nds7
Synonyms Bcl-2, C430015F12Rik, D830018M01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
49.76 cM
Detailed Genetic Map ± 1 cM

Mapping data(38)
Sequence Map
Chr1:106538178-106714274 bp, - strand
From VEGA annotation of GRCm38

  176097 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: apoptosis regulator, Bcl2 type
Gene Tree: Bcl2

Human Homolog BCL2, B-cell CLL/lymphoma 2
NCBI Gene ID 596
neXtProt AC  NX_P10415
Human Synonyms  Bcl-2, PPP1R50
Human Chr (Location)  18q21.3; chr18:63123346-63319778 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human BCL2
alleles, and
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null mutants show pleiotropic abnormalities including small size, increased postnatal mortality, polycystic kidneys, apoptotic involution of thymus and spleen, graying in the second hair follicle cycle, and reduced numbers of motor, sympathetic and sensory neurons.
Phenotype Images(2)
Bcl2 interacts with 434 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (233 annotations)
Process actin filament organization, apoptotic mitochondrial changes, ...
Component cell, cytoplasm, ...
Function BH3 domain binding, BH domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (79 records)
Data Summary: Results (401)    Tissues (191)    Images (12)
Theiler Stages: 1, 2, 3, 4, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 97
RNA in situ 61
Northern blot 18
Western blot 47
RT-PCR 154
RNase protection 5
Nuclease S1 19
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(52) Genomic(15) cDNA(23) Primer pair(12) Other(2)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000022128 (Evidence)
Ensembl Gene ModelENSMUSG00000057329 (Evidence)
Entrez Gene12043 (Evidence)
Consensus CDS ProjectCCDS15209.1
International Mouse Knockout Project StatusBcl2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022128 VEGA Gene Model | MGI Sequence Detail 176097 C57BL/6J ±  kb
transcript OTTMUST00000052517 VEGA | MGI Sequence Detail 7191 Not Applicable 
polypeptide OTTMUSP00000024915 VEGA | MGI Sequence Detail 236 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(14) : PCR(8) RFLP(6) SNPs within 2kb(970 from dbSNP Build 137)    SNPs within 2kb including multiple locations(972)
InterPro IPR013278 Apoptosis regulator, Bcl-2
InterPro IPR004725 Apoptosis regulator, Bcl-2/ BclX
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved site
InterPro IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002307 apoptosis regulator Bcl-2
References (Earliest) J:8659 Negrini M, et al., Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell. 1987 May 22;49(4):455-63
(Latest) J:212559 Moriishi T, et al., Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. PLoS One. 2014;9(1):e86629
All references(442)
accession IDs
MGD-MRK-1524, MGD-MRK-1526, MGI:2138629, MGI:2442315, MGI:2444619, MGI:2444682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory