About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Bcl2
B cell leukemia/lymphoma 2
MGI:88138

123 matching records from 123 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E6.5 E7.5 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E20 E P
Immunohistochemistry (section) 1 2 1 4 3 2 4 1 7 3 3 5 2 8 1 3 8
In situ RNA (section) 1 1 1 1 1 1 1 1 1 1 1 2
Immunohistochemistry (whole mount) 2 1 1 1 2 1
In situ RNA (whole mount) 1
Northern blot 1 1 1 1 1 1 1 2 1 2
Western blot 1 1 1 1 2 1 3 1 4 2 5 2 3 1 3 1 1 3 2 2 19
RT-PCR 3 3 2 1 1 2 1 1 3 3 1 4 2 3 5 1 8 3 6 3 2 2 5 2 4 29
cDNA clones 1
RNase protection 1 1 1 1 2
Nuclease S1 1 1 1 1 1 1 1 1 2 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Bcl2  B cell leukemia/lymphoma 2   (Synonyms: Bcl-2, C430015F12Rik, D830018M01Rik)
Results  Reference
1*J:57870 Abdelwahid E, Pelliniemi LJ, Niinikoski H, Simell O, Tuominen J, Rahkonen O, Jokinen E, Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis. Anat Rec. 1999 Oct 1;256(2):208-17
4*J:34582 Abe-Dohmae S, Harada N, Yamada K, Tanaka R, Bcl-2 gene is highly expressed during neurogenesis in the central nervous system. Biochem Biophys Res Commun. 1993 Mar 31;191(3):915-21
1J:172398 Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W, Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One. 2011;6(4):e19090
2*J:68216 Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H, Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97
1*J:330533 Bakalar D, O'Reilly JJ, Lacaille H, Salzbank J, Ellegood J, Lerch JP, Sasaki T, Imamura Y, Hashimoto-Torii K, Vacher CM, Penn AA, Lack of placental neurosteroid alters cortical development and female somatosensory function. Front Endocrinol (Lausanne). 2022;13:972033
1*J:346773 Barbagallo F, Rotilio V, Assenza MR, Aguanno S, Orsini T, Putti S, Isidori AM, Lenzi A, Naro F, De Angelis L, Pellegrini M, PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis. Int J Mol Sci. 2020 Apr 21;21(8)
1J:209511 Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS, alpha6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14;289(7):3842-55
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
1J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
1J:209730 Cardelli M, Zirngibl RA, Boetto JF, McKenzie KP, Troy TC, Turksen K, Aubin JE, Cartilage-specific overexpression of ERRgamma results in Chondrodysplasia and reduced chondrocyte proliferation. PLoS One. 2013;8(12):e81511
1J:144496 Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G, The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009 Jan 14;29(2):529-42
2*J:38306 Chen DF, Schneider GE, Martinou JC, Tonegawa S, Bcl-2 promotes regeneration of severed axons in mammalian CNS [see comments]. Nature. 1997 Jan 30;385(6615):434-9
1J:342014 Chen Y, Zhou T, Liao Z, Gao W, Wu J, Zhang S, Li Y, Liu H, Zhou H, Xu C, Su P, Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308
3J:208428 Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J, Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol. 2014 Apr;306(7):F764-72
1J:40384 Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH, Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
1*J:296013 Dehghan Z, Mohammadi-Yeganeh S, Salehi M, MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation. Biol Reprod. 2020 Aug 21;103(3):548-559
1J:141953 Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S, Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. Dev Biol. 2008 Aug 7;322(2):302-313
2J:77297 Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 2000 Oct;28(1):115-27
1J:131874 Di-Poi N, Zakany J, Duboule D, Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development. PLoS Genet. 2007 Dec 21;3(12):e232
2J:186281 Ding M, Lu Y, Abbassi S, Li F, Li X, Song Y, Geoffroy V, Im HJ, Zheng Q, Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol. 2012 Oct;227(10):3446-56
1J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104
1*J:157660 Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15;19(6):1048-57
1J:154416 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL, Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep;58(9):2059-69
1*J:54066 Dupe V, Ghyselinck NB, Thomazy V, Nagy L, Davies PJA, Chambon P, Mark M, Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev Biol. 1999 Apr 1;208(1):30-43
3J:129294 Dziarmaga A, Eccles M, Goodyer P, Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J Am Soc Nephrol. 2006 Jun;17(6):1568-75
2J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
1J:82147 Eng SR, Kozlov S, Turner EE, Unaltered expression of Bcl-2 and TAG-1/axonin-1 precedes sensory apoptosis in Brn3a knockout mice. Neuroreport. 2003 Feb 10;14(2):173-6
6*J:56116 Exley GE, Tang C, McElhinny AS, Warner CM, Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos. Biol Reprod. 1999 Jul;61(1):231-9
2*J:178498 Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfo M, De Luca P, de Carvalho DP, Ceccarelli M, De Felice M, Di Lauro R, Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011 Nov 15;359(2):163-75
1*J:85726 Fernandez EL, Gustafson AL, Andersson M, Hellman B, Dencker L, Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc. Toxicol Sci. 2003 Nov;76(1):162-70
2*J:73290 Figueiredo HF, Davis BM, Albers KM, Skin-derived nerve growth factor blocks programmed cell death in the trigeminal ganglia but does not enhance neuron proliferation. Mech Dev. 2001 Dec;109(2):205-14
1*J:199353 Fleury M, Petit-Cocault L, Clay D, Souyri M, Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis. Int J Dev Biol. 2010;54(6-7):1067-74
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1J:302364 Gausseres B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona A, Delangre E, Cruciani-Guglielmacci C, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K, The Constitutive Lack of alpha7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020 Jul 16;10(7):1057
7*J:25204 Gonzalez-Garcia M, Garcia I, Ding L, O'Shea S, Boise LH, Thompson CB, Nunez G, bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4304-8
9*J:20957 Gonzalez-Garcia M, Perez-Ballestero R, Ding L, Duan L, Boise LH, Thompson CB, Nunez G, bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development. 1994 Oct;120(10):3033-42
2J:239805 Grigaravicius P, Kaminska E, Hubner CA, McKinnon PJ, von Deimling A, Frappart PO, Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ. 2016 Mar;23(3):454-68
1J:169736 Gualco E, Urbanska K, Perez-Liz G, Sweet T, Peruzzi F, Reiss K, Del Valle L, IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors. Cell Death Differ. 2010 Mar;17(3):439-51
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4J:126292 Gugasyan R, Christou A, O'Reilly LA, Strasser A, Gerondakis S, Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA. Cell Death Differ. 2006 Jul;13(7):1235-7
1J:274000 Hadden C, Fahmi T, Cooper A, Savenka AV, Lupashin VV, Roberts DJ, Maroteaux L, Hauguel-de Mouzon S, Kilic F, Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway. J Cell Physiol. 2017 Dec;232(12):3520-3529
1J:100886 Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S, A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
1J:220518 Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M, Schrotter S, Eickholt BJ, van den Heuvel L, Casamina C, Stoltenburg-Didinger G, Ropers HH, Wienker TF, Hubner C, Kaindl AM, Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness. Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35
2J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
5*J:34352 Ishii N, Wanaka A, Ohno K, Matsumoto K, Eguchi Y, Mori T, Tsujimoto Y, Tohyama M, Localization of bcl-2, bax, and bcl-x mRNAs in the developing inner ear of the mouse. Brain Res. 1996 Jul 8;726(1-2):123-8
3J:333870 Jazwiec PA, Patterson VS, Ribeiro TA, Yeo E, Kennedy KM, Mathias PCF, Petrik JJ, Sloboda DM, Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biol Reprod. 2022 Aug 9;107(2):574-589
1J:225072 Jimenez-Sanchez M, Menzies FM, Chang YY, Simecek N, Neufeld TP, Rubinsztein DC, The Hedgehog signalling pathway regulates autophagy. Nat Commun. 2012;3:1200
12*J:173710 Jin XL, O'Neill C, Regulation of the expression of proto-oncogenes by autocrine embryotropins in the early mouse embryo. Biol Reprod. 2011 Jun;84(6):1216-24
4J:84726 Joswig A, Gabriel HD, Kibschull M, Winterhager E, Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol. 2003 May 26;1(1):44
8*J:50202 Jurisicova A, Latham KE, Casper RF, Casper RF, Varmuza SL, Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol Reprod Dev. 1998 Nov;51(3):243-53
2J:245423 Kadmiel M, Matson BC, Espenschied ST, Lenhart PM, Caron KM, Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. PLoS One. 2017;12(7):e0181597
1J:243551 Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H, Bhlha9 regulates apical ectodermal ridge formation during limb development. J Bone Miner Metab. 2018 Jan;36(1):64-72
1J:326350 Keppner A, Correia M, Santambrogio S, Koay TW, Maric D, Osterhof C, Winter DV, Clerc A, Stumpe M, Chalmel F, Dewilde S, Odermatt A, Kressler D, Hankeln T, Wenger RH, Hoogewijs D, Androglobin, a chimeric mammalian globin, is required for male fertility. Elife. 2022 Jun 14;11:e72374
1*J:149153 Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Bruning JC, PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol. 2009 Jun;29(11):3173-85
1J:128547 Kluppel M, Wight TN, Chan C, Hinek A, Wrana JL, Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development. 2005 Sep;132(17):3989-4003
2J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
14J:79412 Krajewska M, Mai JK, Zapata JM, Ashwell KW, Schendel SL, Reed JC, Krajewski S, Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system. Cell Death Differ. 2002 Feb;9(2):145-57
6J:47840 Krajewski S, Hugger A, Krajewska M, Reed JC, Mai JK, Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth. Cell Death Differ. 1998 May;5(5):408-15
1*J:60156 Lee K, Lanske B, Karaplis AC, Deeds JD, Kohno H, Nissenson RA, Kronenberg HM, Segre GV, Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996 Nov;137(11):5109-18
1J:177567 Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W, Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
1J:320355 Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J, Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Oncogene. 2016 Mar 17;35(11):1468-74
2*J:316150 Li R, Yang YG, Gao Y, Wang ZQ, Tong WM, A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res. 2012 May;22(5):859-72
1*J:179984 Liu WM, Pang RT, Chiu PC, Wong BP, Lao K, Lee KF, Yeung WS, Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):490-4
4*J:130988 Londhe VA, Nguyen HT, Jeng JM, Li X, Li C, Tiozzo C, Zhu N, Minoo P, NF-kB induces lung maturation during mouse lung morphogenesis. Dev Dyn. 2008 Feb;237(2):328-38
2J:335566 Lu C, Zhang J, Wang B, Gao Q, Ma K, Pei S, Li J, Cui S, Casein kinase 1alpha is required to maintain murine hypothalamic pro-opiomelanocortin expression. iScience. 2023 May 19;26(5):106670
2J:196359 Lu Y, Abbassi S, Li F, Ding M, Wu G, Gu J, Zheng Q, Distinct function of P63 isoforms during embryonic skeletal development. Gene. 2013 May 1;519(2):251-9
1J:199588 Luo XJ, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L, GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Hum Mol Genet. 2013 Sep 15;22(18):3609-23
2J:253948 Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD, Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol. 2016 Aug;97:1-14
1J:175527 Mak MC, Lam KM, Chan PK, Lau YB, Tang WH, Yeung PK, Ko BC, Chung SM, Chung SK, Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function. PLoS One. 2011;6(7):e19186
1J:220108 Marotta P, Amendola E, Scarfo M, De Luca P, Zoppoli P, Amoresano A, De Felice M, Di Lauro R, The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36
1J:68367 Melnick M, Chen H, Zhou YM, Jaskoll T, Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001;168(4):233-45
7J:16873 Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ, bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development. 1994 Feb;120(2):301-11
2*J:84732 Min SH, Hwang DY, Kang TS, Hwang JH, Lim CH, Lee SH, Lim HJ, Seo SJ, Sheen YY, Paik SG, Cho JS, Kim YK, Differential expression of proteins of caspases and Bcl-2 families in the brain of mice. Int J Mol Med. 2003 Aug;12(2):181-3
1J:231873 Mohamed BA, Barakat AZ, Held T, Elkenani M, Muhlfeld C, Manner J, Adham IM, Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014 Apr;50(4):817-24
4*J:16976 Moore NC, Anderson G, Williams GT, Owen JJ, Jenkinson EJ, Developmental regulation of bcl-2 expression in the thymus. Immunology. 1994 Jan;81(1):115-9
1J:42260 Moser M, Pscherer A, Roth C, Becker J, Mucher G, Zerres K, Dixkens C , Weis J , Guay-Woodford L , Buettner R , Fassler R, Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
2*J:75884 Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Fujii E, Hosono T, Murata Y, Sugimoto Y, Ichikawa A, Apoptosis and Related Proteins during Parturition in Prostaglandin F Receptor-Deficient Mice. Biochem Biophys Res Commun. 2002 Apr 5;292(3):675-81
1J:167548 Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M, An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19356-61
1J:230332 Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K, Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Genes Cells. 2015 Jun;20(6):500-11
1J:296081 Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL, Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020 Feb;27(2):742-757
4*J:285867 Ni HM, Chen X, Chen L, DiFrancesca D, Harada H, Yin XM, The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice. Apoptosis. 2008 Jan;13(1):53-62
1J:324629 Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, Matsuda E, Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression. Cell Prolif. 2022 Apr;55(4):e13215
2J:97328 Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T, Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J Clin Invest. 2005 Apr 1;115(4):910-918
10*J:19108 Novack DV, Korsmeyer SJ, Bcl-2 protein expression during murine development [see comments]. Am J Pathol. 1994 Jul;145(1):61-73
3J:90966 Orelio C, Harvey KN, Miles C, Oostendorp RA, van der Horn K, Dzierzak E, The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. Blood. 2004 Jun 1;103(11):4084-92
1J:327300 Pakarinen E, Lindholm P, Saarma M, Lindahl M, CDNF and MANF regulate ER stress in a tissue-specific manner. Cell Mol Life Sci. 2022 Feb 7;79(2):124
1J:110210 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A, Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8090-5
1J:212629 Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K, Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28;111(8):1012-26
1J:142530 Pitera JE, Scambler PJ, Woolf AS, Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet. 2008 Dec 15;17(24):3953-64
1J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
1J:92421 Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM, NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
1J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
5*J:59317 Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P, Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):466-71
1J:63161 Rucker EB 3rd, Dierisseau P, Wagner KU, Garrett L, Wynshaw-Boris A, Flaws JA, Hennighausen L, Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol. 2000 Jul;14(7):1038-52
1J:171312 Sammeta N, Hardin DL, McClintock TS, Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium. Mol Cell Neurosci. 2010 Dec;45(4):398-407
1J:317430 Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021 Dec;17(12):e1009982
4J:185290 Song XF, Ren H, Andreasen A, Thomsen JS, Zhai XY, Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. PLoS One. 2012;7(2):e32771
1*J:34503 Sorenson CM, Rogers SA, Hammerman MR, Abnormal renal development in the Os/+ mouse is intrinsic to the kidney. Am J Physiol. 1996 Jul;271(1 Pt 2):F234-8
2J:236406 Takada Y, Fukuda A, Chiba T, Seno H, Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development. 2016 Oct 1;143(19):3532-3539
1*J:102178 Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG, Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov;25(21):9369-82
1J:242317 Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG, Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4*J:14432 Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ, Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol. 1993 Sep 1;151(5):2546-54
2*J:15224 Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ, Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 1993 Oct 22;75(2):229-40
2J:83651 Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R, Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9
1J:284292 Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X, Zheng Y, Sun M, Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 1;9(5):520
2J:140089 Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX, Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008 Oct 7;14(4):312-23
1J:146172 Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK, Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009 Jan 12;184(1):143-58
1J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14
5*J:49788 Warner CM, Exley GE, McElhinny AS, Tang C, Genetic regulation of preimplantation mouse embryo survival. J Exp Zool. 1998 Sep-Oct 1;282(1-2):272-9
5J:93311 Wiggins AK, Wei G, Doxakis E, Wong C, Tang AA, Zang K, Luo EJ, Neve RL, Reichardt LF, Huang EJ, Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 2004 Nov 25;167(2):257-67
2J:40102 Wlodarczyk BC, Craig JC, Bennett GD, Calvin JA, Finnell RH, Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology. 1996 Dec;54(6):284-97
1J:341382 Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B, Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
1J:212272 Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W, Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
1J:175387 Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I, Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism. Dev Biol. 2011 Aug 15;356(2):337-49
1*J:43079 Yang C, Li SW, Helminen HJ, Khillan JS, Bao Y, Prockop DJ, Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res. 1997 Sep 15;235(2):370-3
1*J:272566 Yang R, Wang H, Kang B, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Xu P, Chang Y, Jia Y, Huang Y, CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
3*J:182696 Yang RT, Zhang C, Liu Y, Zhou HH, Li ZB, Autophagy Prior to Chondrocyte Cell Death During the Degeneration of Meckel's Cartilage. Anat Rec (Hoboken). 2012 May;295(5):734-41
1*J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1J:210623 Yeh ML, Gonda Y, Mommersteeg MT, Barber M, Ypsilanti AR, Hanashima C, Parnavelas JG, Andrews WD, Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
1J:304122 Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H, Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 Jul 17;9(7):1714
1J:58207 Zorbas M, Sicurella C, Bertoncello I, Venter D, Ellis S, Mucenski ML, Ramsay RG, c-Myb is critical for murine colon development. Oncogene. 1999 Oct 14;18(42):5821-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory