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Avp Gene Detail
Summary
  • Symbol
    Avp
  • Name
    arginine vasopressin
  • Synonyms
    Vp, Vsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88121
    NCBI Gene: 11998
  • Gene Overview
    MyGene.info: AVP
Location & Maps
more
  • Sequence Map
    Chr2:130580620-130582554 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1935 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    AVP, arginine vasopressin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AVP, arginine vasopressin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADH, ARVP, AVP-NPII, AVRP, VP
  • Links
    NCBI Gene ID: 551
    neXtProt AC: NX_P01185

  • Chr Location
    20p13; chr20:3082555-3093521 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Avp mouse models; 1 with human AVP associations

Human Disease Mouse Models
       Diabetes Insipidus, Neurohypophyseal   OMIM: 125700 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Avp
  • Incidental Mutations
    APF
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015526 VEGA Gene Model | MGI Sequence Detail 1935 C57BL/6J ±  kb
transcript OTTMUST00000036871 VEGA | MGI Sequence Detail 577 Not Applicable  
polypeptide OTTMUSP00000016544 VEGA | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004523 vasopressin-neurophysin 2-copeptin
  • InterPro Domains
    IPR000981 Neurohypophysial hormone
    IPR022423 Neurohypophysial hormone, conserved site
Molecular
Reagents
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  • All nucleic 29
    Genomic 10
    cDNA 17
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416
References
more
  • Summaries
    All 106
    Developmental Gene Expression 47
    Diseases 2
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:10931 Hara Y, et al., Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res. 1990 Oct;8(4):319-24
  • Latest
    J:229100 Goto M, et al., Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development. Brain Res. 2015 Nov 2;1625:206-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory