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Avp Gene Detail
Summary
  • Symbol
    Avp
  • Name
    arginine vasopressin
  • Synonyms
    Vp, Vsp
Location &
Maps
more
  • Sequence Map
    Chr2:130422540-130424474 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88121
 protein coding gene Chr2:130422540-130424508 (-)
129S1/SvImJ ENSMUSG00200047631
 protein coding gene Chr2:127465349-127467283 (-)
A/J ENSMUSG00195027711
 protein coding gene Chr2:127498530-127500465 (-)
AKR/J ENSMUSG00220040096
 protein coding gene Chr2:127258930-127260864 (-)
BALB/cJ ENSMUSG00180048020
 protein coding gene Chr2:127308355-127310288 (-)
C3H/HeJ ENSMUSG00175045922
 protein coding gene Chr2:127845986-127847920 (-)
C57BL/6NJ ENSMUSG00215031146
 protein coding gene Chr2:127346579-127348513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024307
 protein coding gene Chr2:123364046-123366006 (-)
CAST/EiJ ENSTCUG00005035333
 protein coding gene Chr2:126616813-126618746 (-)
CBA/J ENSMUSG00210027879
 protein coding gene Chr2:127702878-127704812 (-)
DBA/2J ENSMUSG00185031596
 protein coding gene Chr2:127351456-127353390 (-)
FVB/NJ ENSMUSG00205039841
 protein coding gene Chr2:126517983-126519917 (-)
JF1/MsJ ENSUMUG00000018475
 protein coding gene Chr2:127161875-127163808 (-)
LP/J ENSMUSG00230038882
 protein coding gene Chr2:129100562-129102496 (-)
NOD/ShiLtJ ENSMUSG00190014333
 protein coding gene Chr2:127460386-127462320 (-)
NZO/HlLtJ ENSMUSG00225026880
 protein coding gene Chr2:137009400-137011334 (-)
PWK/PhJ ENSLUMG00010037900
 protein coding gene Chr2:127120844-127122777 (-)
SPRET/EiJ ENSMSPG00010026845
 protein coding gene Chr2:129506142-129508046 (-)
WSB/EiJ ENSIUOG00005037556
 protein coding gene Chr2:127282163-127284097 (-)



Homology
more
  • Human Ortholog
    AVP, arginine vasopressin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AVP, arginine vasopressin
  • Synonyms
    ADH, ARVP, AVP-NPII, AVRP, VP
  • Links
    NCBI Gene ID: 551
    UniProt: P01185

  • Chr Location
    20p13; chr20:3082556-3084724 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Avp mouse models; 4 with human AVP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 5 genetic backgrounds
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1070
  • Tissues
    228
  • cDNA Data
    18
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037727 Ensembl Gene Model | MGI Sequence Detail 1935 C57BL/6J ±  kb
    transcript ENSMUST00000046001 Ensembl | MGI Sequence Detail 577 Not Applicable  
    polypeptide ENSMUSP00000035551 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004523 vasopressin-neurophysin 2-copeptin
      (term hierarchy)
    • InterPro Domains
      IPR000981 Neurohypophysial hormone
      IPR022423 Neurohypophysial hormone, conserved site
      IPR036387 Neurohypophysial hormone domain superfamily
    • GlyGen
      P35455 1 site, 4 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 10
      cDNA 19
      Primer pair 4
      Other 7
      Antibodies 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416
    References
    more
    • Summaries
      All 234
      Developmental Gene Expression 66
      Diseases 2
      Gene Ontology 6
      Phenotypes 94
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391089 Morones N, et al., The role of supraoptic hypothalamic arginine vasopressin neurons in aging-associated water balance and thermoregulatory deficits in male mice. Nat Commun. 2026 Jun 27;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory