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Avp
Gene Detail
 Symbol
Name
ID
Avp
arginine vasopressin
MGI:88121
Synonyms Vp, Vsp
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:130580620-130582554 bp, - strand
From VEGA annotation of GRCm38

  1935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nonapeptide hormone precursor
Gene Tree: Avp

Human
homologs
Human Homolog AVP, arginine vasopressin
NCBI Gene ID 551
neXtProt AC  NX_P01185
Human Synonyms  ADH, ARVP, AVP-NPII, AVRP, VP
Human Chr (Location)  20p13; chr20:3082556-3084724 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AVP
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
 
Human Diseases Modeled Using Mouse Avp (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process ERK1 and ERK2 cascade, grooming behavior, ...
Component dendrite, extracellular region, ...
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (284)    Tissues (189)    Images (21)
Theiler Stages: 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 30
RNA in situ 254
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(29) Genomic(10) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015526 (Evidence)
Ensembl Gene ModelENSMUSG00000037727 (Evidence)
Entrez Gene11998 (Evidence)
UniGene6190
DFCITC1586254
DoTSDT.489029
Consensus CDS ProjectCCDS16746.1
International Mouse Knockout Project StatusAvp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015526 VEGA Gene Model | MGI Sequence Detail 1935 C57BL/6J ±  kb
transcript OTTMUST00000036871 VEGA | MGI Sequence Detail 577 Not Applicable 
polypeptide OTTMUSP00000016544 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000981 Neurohypophysial hormone
InterPro IPR022423 Neurohypophysial hormone, conserved site
Protein Ontology PR:000004523 vasopressin-neurophysin 2-copeptin
References (Earliest) J:10931 Hara Y, et al., Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res. 1990 Oct;8(4):319-24
(Latest) J:198684 Trowe MO, et al., Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
All references(94)
Other
accession IDs
MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory