About   Help   FAQ
Avp Gene Detail
Summary
  • Symbol
    Avp
  • Name
    arginine vasopressin
  • Synonyms
    Vp, Vsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88121
    NCBI Gene: 11998
  • Gene Overview
    MyGene.info: AVP
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130580620-130582554 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88121
protein coding gene Chr2:130580620-130582588 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026509
protein coding gene Chr2:134046637-134048571 (-)
A/J MGP_AJ_G0026473
protein coding gene Chr2:128620032-128621966 (-)
AKR/J MGP_AKRJ_G0026448
protein coding gene Chr2:132329674-132331608 (-)
BALB/cJ MGP_BALBcJ_G0026485
protein coding gene Chr2:128975051-128976984 (-)
C3H/HeJ MGP_C3HHeJ_G0026228
protein coding gene Chr2:132760919-132762853 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026930
protein coding gene Chr2:138187376-138189310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024307
protein coding gene Chr2:123364046-123366006 (-)
CAST/EiJ MGP_CASTEiJ_G0025689
protein coding gene Chr2:133016668-133018601 (-)
CBA/J MGP_CBAJ_G0026208
protein coding gene Chr2:143295937-143297871 (-)
DBA/2J MGP_DBA2J_G0026342
protein coding gene Chr2:128006870-128008804 (-)
FVB/NJ MGP_FVBNJ_G0026306
protein coding gene Chr2:126634534-126636468 (-)
LP/J MGP_LPJ_G0026447
protein coding gene Chr2:134291833-134293767 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026326
protein coding gene Chr2:147144975-147146909 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026985
protein coding gene Chr2:132283979-132285913 (-)
PWK/PhJ MGP_PWKPhJ_G0025425
protein coding gene Chr2:127563245-127565178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025227
protein coding gene Chr2:131407030-131408934 (-)
WSB/EiJ MGP_WSBEiJ_G0025763
protein coding gene Chr2:133206754-133208688 (-)



Homology
more
  • Human Ortholog
    AVP, arginine vasopressin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AVP, arginine vasopressin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADH, ARVP, AVP-NPII, AVRP, VP
  • Links
    NCBI Gene ID: 551
    neXtProt AC: NX_P01185
    UniProt: P01185

  • Chr Location
    20p13; chr20:3082555-3093521 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Avp mouse models; 1 with human AVP associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037727 Ensembl Gene Model | MGI Sequence Detail 1935 C57BL/6J ±  kb
    transcript ENSMUST00000046001 Ensembl | MGI Sequence Detail 577 Not Applicable  
    polypeptide ENSMUSP00000035551 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 10
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 51
      Diseases 2
      Gene Ontology 4
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263835 Newman EA, et al., Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Jul 15;439(2):102-111

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory