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Atp1b1
Gene Detail
 Symbol
Name
ID
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
MGI:88108
Synonyms Atpb, Atpb-1, sodium/potassium ATPase beta subunit
Feature Type protein coding gene
Genetic Map
Chromosome 1
71.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:164437267-164458355 bp, - strand
From NCBI annotation of GRCm38

  21089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase beta chain
Gene Tree: Atp1b1

Human
homologs
Human Homolog ATP1B1, ATPase, Na+/K+ transporting, beta 1 polypeptide
NCBI Gene ID 481
neXtProt AC  NX_P05026
Human Synonyms  ATP1B
Human Chr (Location)  1q24; chr1:169106709-169132722 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATP1B1
Alleles
and
phenotypes
All alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditional allele activated in cardiac tissue exhibit age-related cardiac hypertrophy and reduced cardiac function, insensitivity to ouabain, and increased heart dysfunction following aortic constriction.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ATP catabolic process, blastocyst development, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function MHC class II protein complex binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (678)    Tissues (372)    Images (65)
Theiler Stages: 3, 4, 5, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 642
Northern blot 10
Western blot 10
RT-PCR 6
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000026576 (Evidence)
Entrez Gene11931 (Evidence)
DFCITC1573235, TC1643717, TC1748689
NIA Mouse Gene IndexU021983
Consensus CDS ProjectCCDS35755.1
International Mouse Knockout Project StatusAtp1b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11931 NCBI Gene Model | MGI Sequence Detail 21089 C57BL/6J ±  kb
transcript NM_009721 RefSeq | MGI Sequence Detail 2590 C57BL/6 
polypeptide P14094 UniProt | EBI | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000402 Sodium/potassium-transporting ATPase subunit beta
InterPro IPR015565 Sodium/potassium-transporting ATPase subunit beta, chordates
Protein Ontology PR:000004439 sodium/potassium-transporting ATPase subunit beta-1
Graphical View of Protein Domain Structure
References (Earliest) J:19611 Mercer RW, et al., Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986 Nov;6(11):3884-90
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(76)
Other
accession IDs
MGD-MRK-1460, MGD-MRK-1473, MGD-MRK-1474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory