Atp1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
MGI:88108

49 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aqp5^{tm1.1(cre)Pfl}/? Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro 129S-Atp1b1^tm1.1Zboro Aqp5^{tm1.1(cre)Pfl}	impaired pulmonary alveolar fluid clearance	J:233742
	normal respiratory system phenotype	J:233742
Atp1b1^em1(IMPC)Mbp/Atp1b1⁺ C57BL/6NCrl-Atp1b1^em1(IMPC)Mbp/Mmucd	abnormal retina morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	decreased locomotor activity	J:211773
	enlarged testis	J:211773
	eye hemorrhage	J:211773
	increased startle reflex	J:211773
	persistence of hyaloid vascular system	J:211773
	shortened QRS complex duration	J:211773
Atp1b1^em1(IMPC)Mbp/Atp1b1^em1(IMPC)Mbp C57BL/6NCrl-Atp1b1^em1(IMPC)Mbp/Mmucd	abnormal embryo turning	J:211773
	abnormal forebrain morphology	J:374598
	abnormal head shape	J:374598
	abnormal heart morphology	J:211773, J:374598
	abnormal heart shape	J:374598
	abnormal neural tube closure	J:211773
	abnormal neural tube morphology	J:211773
	abnormal optic vesicle formation	J:211773
	abnormal pharyngeal arch morphology	J:211773, J:374598
	abnormal somite shape	J:211773
	abnormal visceral yolk sac morphology	J:211773
	abnormal vitelline vasculature morphology	J:211773
	decreased embryo size	J:374598
	delayed rostral neuropore closure	J:374598
	normal embryo phenotype	J:374598
	embryonic growth retardation	J:211773, J:374598
	embryonic lethality during organogenesis, complete penetrance	J:374598
	failure of initiation of embryo turning	J:374598
	incomplete embryo turning	J:374598
	incomplete rostral neuropore closure	J:374598
	kinked neural tube	J:374598
	kinked tail	J:374598
	pericardial edema	J:374598
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra involves: 129S/SvEv	no abnormal phenotype detected	J:152596
Atp1b1^tm1.1Akra/Atp1b1^tm1.1Akra Myl2^tm1(cre)Krc/Myl2⁺ involves: 129S/SvEv * 129S4/SvJae	abnormal cardiac muscle contractility	J:152596
	abnormal myocardial fiber physiology	J:152596
	cardiac hypertrophy	J:152596
	decreased heart ventricle muscle contractility	J:152596
	decreased physiological sensitivity to xenobiotic	J:152596
	increased heart weight	J:152596
	increased response of heart to induced stress	J:152596
	increased susceptibility to induced morbidity/mortality	J:152596
Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Nkx2-1-cre)2Sand/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	postnatal lethality, complete penetrance	J:233742
Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Sftpc-cre)1Blh/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal respiratory epithelial sodium ion transmembrane transport	J:233742
	impaired pulmonary alveolar fluid clearance	J:233742
	normal respiratory system phenotype	J:233742

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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