Atp1a3
Gene Detail

Symbol Name ID

Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide MGI:88107

Synonyms

Atpa-2, MGC:27631, MGC:38713, MGC:38914, MGC:39036

Feature Type

protein coding gene

Genetic Map

Chromosome 7

13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr7:24978167-25005957 bp, - strand From VEGA annotation of GRCm38   27791 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Atp1a3 ± 2 cM)

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a3

Human ortholog

ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide NCBI Gene ID 478
Human Synonyms: AHC2, DYT12, RDP
Human Chr19:42470734-42498382 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ATP1A3 (2)

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Chemically induced(1)
 

Mice homozygous for a mutation in this gene display neonatal lethality. Heterozygous mice display hyperactivity, increased activity in responses to methamphetamine, and impaired spatial learning. Mice heterozygous for an ENU mutation exhibit convulsive and vestibular stress induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	adult locomotory behavior, ATP biosynthetic process, ...
Component	axon, cytoplasm, ...
Function	ATP binding, cation-transporting ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (132)    Tissues (109)    Images (15)
Theiler Stages: 2, 3, 4, 5, 22, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	94
Western blot	15
RT-PCR	19

cDNA source data(116)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(125) cDNA(121) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016491 (Evidence)
Ensembl Gene Model	ENSMUSG00000040907 (Evidence)
Entrez Gene	232975 (Evidence)
UniGene	44101
DFCI	TC1575876, TC1596218
DoTS	DT.40137679, DT.99852178
NIA Mouse Gene Index	U028264
EC	3.6.3.9
Consensus CDS Project	CCDS20969.1
International Mouse Knockout Project Status	Atp1a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016491	VEGA Gene Model | MGI Sequence Detail	27791	C57BL/6J
transcript	OTTMUST00000039800	VEGA | MGI Sequence Detail	3895	Not Applicable
polypeptide	OTTMUSP00000017755	VEGA | MGI Sequence Detail	1053	Not Applicable

All sequences(37) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(5) : SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR005775	ATPase, P-type cation exchange, alpha subunit, eukaryotic
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004437	sodium/potassium-transporting ATPase subunit alpha-3

References

(Earliest) J:8782 Kent RB, et al., Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5369-73
(Latest) J:185703 Kirshenbaum GS, et al., Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress. Genes Brain Behav. 2011 Jul;10(5):542-50
All references(55)

Other accession IDs

MGD-MRK-1459, MGD-MRK-1471