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Atp1a3
Gene Detail
Symbol

Name
ID
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
MGI:88107
Synonyms
Atpa-2, MGC:27631, MGC:38713, MGC:38914, MGC:39036
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr7:24978167-25005957 bp, - strand
From VEGA annotation of GRCm38

  27791 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a3

Human
homologs
Human Homolog ATP1A3, ATPase, Na+/K+ transporting, alpha 3 polypeptide
NCBI Gene ID 478
neXtProt AC  NX_P13637
Human Synonyms  AHC2, CAPOS, DYT12, RDP
Human Chr (Location)  19q13.31; chr19:41966476-41994276 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ATP1A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a mutation in this gene display neonatal lethality. Heterozygous mice display hyperactivity, increased activity in responses to methamphetamine, and impaired spatial learning. Mice heterozygous for an ENU mutation exhibit convulsive and vestibular stress induced seizures.
 
Interactions
Atp1a3 interacts with 90 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process adult locomotory behavior, ATP catabolic process, ...
Component axon, cytoplasm, ...
Function ATP binding, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (120)    Tissues (107)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 94
Western blot 13
RT-PCR 9
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016491 (Evidence)
Ensembl Gene ModelENSMUSG00000040907 (Evidence)
Entrez Gene232975 (Evidence)
DFCITC1575876, TC1596218
DoTSDT.40137679, DT.99852178
NIA Mouse Gene IndexU028264
EC3.6.3.9
Consensus CDS ProjectCCDS20969.1
International Mouse Knockout Project StatusAtp1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016491 VEGA Gene Model | MGI Sequence Detail 27791 C57BL/6J ±  kb
transcript OTTMUST00000039800 VEGA | MGI Sequence Detail 3895 Not Applicable 
polypeptide OTTMUSP00000017755 VEGA | MGI Sequence Detail 1053 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(5) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004437 sodium/potassium-transporting ATPase subunit alpha-3
References
(Earliest) J:8782 Kent RB, et al., Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5369-73
(Latest) J:208021 Kirshenbaum GS, et al., Attenuation of mania-like behavior in Na(+),K(+)-ATPase alpha3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise. Neuroscience. 2014 Feb 28;260:195-204
All references(60)
Other
accession IDs
MGD-MRK-1459, MGD-MRK-1471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory