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Apoc3 Gene Detail
Summary
  • Symbol
    Apoc3
  • Name
    apolipoprotein C-III
  • Feature Type
    protein coding gene
  • IDs
    MGI:88055
    NCBI Gene: 11814
  • Gene Overview
    MyGene.info: APOC3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46233050-46235636 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    5 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88055
protein coding gene Chr9:46232933-46235636 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034749
protein coding gene Chr9:44863037-44867006 (-)
A/J MGP_AJ_G0034730
protein coding gene Chr9:43578727-43581485 (-)
AKR/J MGP_AKRJ_G0034657
protein coding gene Chr9:44466896-44469627 (-)
BALB/cJ MGP_BALBcJ_G0034721
protein coding gene Chr9:43300238-43302908 (-)
C3H/HeJ MGP_C3HHeJ_G0034432
protein coding gene Chr9:44940961-44943631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035242
protein coding gene Chr9:46143798-46146471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032156
protein coding gene Chr9:43109265-43111941 (-)
CAST/EiJ MGP_CASTEiJ_G0033754
protein coding gene Chr9:44799050-44803658 (-)
CBA/J MGP_CBAJ_G0034404
protein coding gene Chr9:47829041-47831728 (-)
DBA/2J MGP_DBA2J_G0034563
protein coding gene Chr9:43450011-43452720 (-)
FVB/NJ MGP_FVBNJ_G0034504
protein coding gene Chr9:42713766-42716438 (-)
LP/J MGP_LPJ_G0034644
protein coding gene Chr9:45181558-45184229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034548
protein coding gene Chr9:49577709-49580397 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035263
protein coding gene Chr9:44386016-44388720 (-)
PWK/PhJ MGP_PWKPhJ_G0033459
protein coding gene Chr9:43369005-43371757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033295
protein coding gene Chr9:44714638-44717327 (-)
WSB/EiJ MGP_WSBEiJ_G0033867
protein coding gene Chr9:44435012-44437693 (-)



Homology
more
  • Human Ortholog
    APOC3, apolipoprotein C3
  • Vertebrate Orthologs
    2
  • Human Ortholog
    APOC3, apolipoprotein C3
    Orthology source: HGNC
  • Synonyms
    APOCIII
  • Links
    NCBI Gene ID: 345
    neXtProt AC: NX_P02656
    UniProt: P02656

  • Chr Location
    11q23.3; chr11:116829908-116833071 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human APOC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced fasted triglyceride levels, increased triglyceride secretion rate, and loss of postprandial and obesity-associated hypertriglyceridemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11814 NCBI Gene Model | MGI Sequence Detail 2587 C57BL/6J ±  kb
    transcript NM_001289755 RefSeq | MGI Sequence Detail 631 C57BL/6  
    polypeptide P33622 UniProt | EBI | MGI Sequence Detail 99 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      Genomic 3
      cDNA 150

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1371, MGD-MRK-1374
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
    • Latest
      J:287457 Zhang Y, et al., Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice. Cell Death Dis. 2019 Sep 30;10(10):728

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory