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Apoc3 Gene Detail
Summary
  • Symbol
    Apoc3
  • Name
    apolipoprotein C-III
  • Feature Type
    protein coding gene
  • IDs
    MGI:88055
    NCBI Gene: 11814
  • Gene Overview
    MyGene.info: APOC3
Location & Maps
more
  • Sequence Map
    Chr9:46232933-46235636 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2704 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    5 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    APOC3, apolipoprotein C3
  • Vertebrate Orthologs
    2
  • Human Ortholog
    APOC3, apolipoprotein C3
    Orthology source: HGNC
  • Synonyms
    APOCIII, HALP2
  • Links
    NCBI Gene ID: 345
    neXtProt AC: NX_P02656

  • Chr Location
    11q23.3; chr11:116829908-116833071 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human APOC3 associations

Human Disease Mouse Models
       Apolipoprotein C-Iii Deficiency   OMIM: 614028
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    4
  • Genomic Mutations
    1 involving Apoc3
Homozygotes for a targeted null mutation exhibit reduced fasted triglyceride levels, increased triglyceride secretion rate, and loss of postprandial and obesity-associated hypertriglyceridemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028703 VEGA Gene Model | MGI Sequence Detail 2704 C57BL/6J ±  kb
transcript OTTMUST00000071086 VEGA | MGI Sequence Detail 709 Not Applicable  
polypeptide OTTMUSP00000036350 VEGA | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 152
    Genomic 3
    cDNA 149

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-1371, MGD-MRK-1374
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 8
    Phenotypes 27
  • Earliest
    J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
  • Latest
    J:221652 Avall K, et al., Apolipoprotein CIII links islet insulin resistance to beta-cell failure in diabetes. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2611-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory