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Apoc2 Gene Detail
Summary
  • Symbol
    Apoc2
  • Name
    apolipoprotein C-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88054
    NCBI Gene: 11813
  • Gene Overview
    MyGene.info: APOC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:19671579-19677941 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6363 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    APOC2, apolipoprotein C2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APOC2, apolipoprotein C2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APO-CII, APOC-II
  • Links
    NCBI Gene ID: 344
    neXtProt AC: NX_P02655
    UniProt: P02655

  • Chr Location
    19q13.32; chr19:44945982-44949565 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032974 VEGA Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
    transcript OTTMUST00000082221 VEGA | MGI Sequence Detail 727 Not Applicable  
    polypeptide OTTMUSP00000044049 VEGA | MGI Sequence Detail 97 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      72 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      Genomic 1
      cDNA 101
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1373
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 15
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:227332 Sakurai T, et al., Creation of ApoC-II Mutant Mice and Correction of their Hypertriglyceridemia with an ApoC-II Mimetic Peptide. J Pharmacol Exp Ther. 2015 Nov 16;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory