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Apoc2 Gene Detail
Summary
  • Symbol
    Apoc2
  • Name
    apolipoprotein C-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88054
    NCBI Gene: 11813
  • Gene Overview
    MyGene.info: APOC2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19671579-19677941 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88054
protein coding gene Chr7:19671579-19677941 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031789
protein coding gene Chr7:17711938-17721164 (-)
A/J MGP_AJ_G0031765
protein coding gene Chr7:17321205-17331193 (-)
AKR/J MGP_AKRJ_G0031691
protein coding gene Chr7:17800309-17811212 (-)
BALB/cJ MGP_BALBcJ_G0031770
protein coding gene Chr7:17527785-17536446 (-)
C3H/HeJ MGP_C3HHeJ_G0031492
protein coding gene Chr7:18067193-18076118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032236
protein coding gene Chr7:18577328-18589037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029302
protein coding gene Chr7:18971125-18981262 (-)
CAST/EiJ MGP_CASTEiJ_G0030835
protein coding gene Chr7:14503550-14512535 (-)
CBA/J MGP_CBAJ_G0031454
protein coding gene Chr7:19260749-19269864 (-)
DBA/2J MGP_DBA2J_G0031609
protein coding gene Chr7:17272998-17284841 (-)
FVB/NJ MGP_FVBNJ_G0031561
protein coding gene Chr7:17142976-17153415 (-)
LP/J MGP_LPJ_G0031692
protein coding gene Chr7:18023310-18032787 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031597
protein coding gene Chr7:19085061-19093894 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032264
protein coding gene Chr7:17412618-17423829 (-)
PWK/PhJ MGP_PWKPhJ_G0030559
protein coding gene Chr7:14371109-14382647 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030386
protein coding gene Chr7:12122731-12131573 (-)
WSB/EiJ MGP_WSBEiJ_G0030935
protein coding gene Chr7:17629798-17640064 (-)



Homology
more
  • Human Ortholog
    APOC2, apolipoprotein C2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APOC2, apolipoprotein C2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APO-CII, APOC-II
  • Links
    NCBI Gene ID: 344
    neXtProt AC: NX_P02655
    UniProt: P02655

  • Chr Location
    19q13.32; chr19:44945982-44949565 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11813 NCBI Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
    transcript NM_001277944 RefSeq | MGI Sequence Detail 727 C57BL/6  
    polypeptide NP_001264873 RefSeq | MGI Sequence Detail 97 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 102
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1373
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 16
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory