About   Help   FAQ
Apoc2 Gene Detail
Summary
  • Symbol
    Apoc2
  • Name
    apolipoprotein C-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88054
    NCBI Gene: 11813
  • Gene Overview
    MyGene.info: APOC2
Location & Maps
more
  • Sequence Map
    Chr7:19671579-19677941 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6363 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    APOC2, apolipoprotein C2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APOC2, apolipoprotein C2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APO-CII, APOC-II
  • Links
    NCBI Gene ID: 344
    neXtProt AC: NX_P02655

  • Chr Location
    19q13.32; chr19:44945982-44949565 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human APOC2 associations

Human Disease Mouse Models
       Apolipoprotein C-II Deficiency   OMIM: 207750
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Endonuclease-mediated
    2
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032974 VEGA Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
transcript OTTMUST00000082221 VEGA | MGI Sequence Detail 727 Not Applicable  
polypeptide OTTMUSP00000044049 VEGA | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    72 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    Genomic 1
    cDNA 101
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1373
References
more
  • Summaries
    All 40
    Developmental Gene Expression 15
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
  • Latest
    J:227332 Sakurai T, et al., Creation of ApoC-II Mutant Mice and Correction of their Hypertriglyceridemia with an ApoC-II Mimetic Peptide. J Pharmacol Exp Ther. 2015 Nov 16;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory