Apoa1
Gene Detail

Symbol Name ID

Apoa1 apolipoprotein A-I MGI:88049

Synonyms

Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

25.36 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(69)

Sequence Map

Chr9:46228580-46230466 bp, + strand From VEGA annotation of GRCm38   1887 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:47900  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Apoa1

Human homologs

Human Homolog		APOA1, apolipoprotein A-I
NCBI Gene ID		335
neXtProt AC		NX_P02647
Human Chr (Location)		11q23-q24; chr11:116835751-116837622 (-)  GRCh38
Disease Associations		(3) Diseases Associated with Human APOA1

Alleles and phenotypes

All alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.

 

Gene Ontology (GO) classifications

All GO classifications: (97 annotations)

Process	adrenal gland development, blood vessel endothelial cell migration, ...
Component	blood microparticle, cell surface, ...
Function	apolipoprotein A-I receptor binding, apolipoprotein receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (31 records)

Data Summary: Results (50)    Tissues (15)    Images (28)
Theiler Stages: 13, 15, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	29
Northern blot	4
RT-PCR	17

cDNA source data(1024)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1036) Genomic(5) cDNA(1025) Primer pair(5) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028707 (Evidence)
Ensembl Gene Model	ENSMUSG00000032083 (Evidence)
Entrez Gene	11806 (Evidence)
UniGene	26743
DFCI	TC1573793, TC1592521
DoTS	DT.101741108, DT.40176266, DT.94156432, DT.99871655
NIA Mouse Gene Index	U010434
PDB	2LEM
Consensus CDS Project	CCDS40610.1
International Mouse Knockout Project Status	Apoa1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028707	VEGA Gene Model | MGI Sequence Detail	1887	C57BL/6J
transcript	OTTMUST00000071093	VEGA | MGI Sequence Detail	1035	Not Applicable
polypeptide	OTTMUSP00000036355	VEGA | MGI Sequence Detail	264	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000074	Apolipoprotein A1/A4/E
Protein Ontology	PR:000004140	apolipoprotein A-I

References

(Earliest) J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
(Latest) J:206959 Huang Y, et al., An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med. 2014 Feb;20(2):193-203
All references(235)

Other accession IDs

MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639