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Apoa1 Gene Detail
Summary
  • Symbol
    Apoa1
  • Name
    apolipoprotein A-I
  • Synonyms
    Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88049
    NCBI Gene: 11806
  • Gene Overview
    MyGene.info: APOA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:46228580-46230466 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1887 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM, cytoband A2-A4
  • Mapping Data
    69 experiments
Homology
more
  • Human Ortholog
    APOA1, apolipoprotein A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    APOA1, apolipoprotein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    apo(a)
  • Links
    NCBI Gene ID: 335
    neXtProt AC: NX_P02647
    UniProt: P02647

  • Chr Location
    11q23.3; chr11:116835751-116837950 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 47900
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APOA1
  • Gene Tree
    Apoa1
Human Diseases
more
  • Diseases
    1 with human APOA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 6 genetic backgrounds
    38 phenotypes from multigenic genotypes
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    50
  • Tissues
    15
  • cDNA Data
    1025
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028707 VEGA Gene Model | MGI Sequence Detail 1887 C57BL/6J ±  kb
    transcript OTTMUST00000071093 VEGA | MGI Sequence Detail 1035 Not Applicable  
    polypeptide OTTMUSP00000036355 VEGA | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      64 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1037
      Genomic 5
      cDNA 1026
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639
    References
    more
    • Summaries
      All 311
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 38
      Phenotypes 124
    • Earliest
      J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
    • Latest
      J:263208 Yang M, et al., Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure. Sci Rep. 2018 Apr 4;8(1):5620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory