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Apoa1
Gene Detail
Symbol

Name
ID
Apoa1
apolipoprotein A-I
MGI:88049
Synonyms
Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.36 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(69)
Sequence Map
Chr9:46228580-46230466 bp, + strand
From VEGA annotation of GRCm38

  1887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47900  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: APOA1
Gene Tree: Apoa1

Human
homologs
APOA1, apolipoprotein A-I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 335
neXtProt AC: NX_P02647

Human Chr (Location): 11q23-q24; chr11:116835751-116837647 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human APOA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Genomic Mutations involving Apoa1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.
 
Interactions
Apoa1 interacts with 10 markers (Mir147, Mir325, Mir471, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (31 records)
Data Summary: Results (50)    Tissues (15)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Northern blot 4
RT-PCR 17
cDNA source data(1024)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apoa1 ; ZFIN apoa1a, apoa1b    NEW 
Molecular
reagents
All nucleic(1036) Genomic(5) cDNA(1025) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028707 (Evidence)
Ensembl Gene Model ENSMUSG00000032083 (Evidence)
Entrez Gene 11806 (Evidence)
UniGene 26743
DFCI TC1573793, TC1592521
DoTS DT.101741108, DT.40176266, DT.94156432, DT.99871655
NIA Mouse Gene Index U010434
PDB 2LEM
Consensus CDS Project CCDS40610.1
International Mouse Phenotyping Consortium Status Apoa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028707 VEGA Gene Model | MGI Sequence Detail 1887 C57BL/6J ±  kb
transcript OTTMUST00000071093 VEGA | MGI Sequence Detail 1035 Not Applicable 
polypeptide OTTMUSP00000036355 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004140 apolipoprotein A-I
References
(Earliest) J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
(Latest) J:219836 Sontag TJ, et al., Alginic acid cell entrapment: a novel method for measuring in vivo macrophage cholesterol homeostasis. J Lipid Res. 2015 Feb;56(2):470-83
All references(236)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory