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Apoa1
Gene Detail
 Symbol
Name
ID
Apoa1
apolipoprotein A-I
MGI:88049
Synonyms Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
25.36 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(69)
Sequence Map
Chr9:46228580-46230466 bp, + strand
From VEGA annotation of GRCm38

  1887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47900  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Apoa1

Human
homologs
Human Homolog APOA1, apolipoprotein A-I
NCBI Gene ID 335
neXtProt AC  NX_P02647
Human Chr (Location)  11q23-q24; chr11:116835751-116837622 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human APOA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.
 
Interactions
Apoa1 interacts with 10 markers (Mir147, Mir325, Mir471, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process adrenal gland development, blood vessel endothelial cell migration, ...
Component blood microparticle, cell surface, ...
Function apolipoprotein A-I receptor binding, apolipoprotein receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (50)    Tissues (15)    Images (28)
Theiler Stages: 13, 15, 17, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 29
Northern blot 4
RT-PCR 17
cDNA source data(1024)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1036) Genomic(5) cDNA(1025) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028707 (Evidence)
Ensembl Gene ModelENSMUSG00000032083 (Evidence)
Entrez Gene11806 (Evidence)
UniGene26743
DFCITC1573793, TC1592521
DoTSDT.101741108, DT.40176266, DT.94156432, DT.99871655
NIA Mouse Gene IndexU010434
PDB2LEM
Consensus CDS ProjectCCDS40610.1
International Mouse Knockout Project StatusApoa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028707 VEGA Gene Model | MGI Sequence Detail 1887 C57BL/6J ±  kb
transcript OTTMUST00000071093 VEGA | MGI Sequence Detail 1035 Not Applicable 
polypeptide OTTMUSP00000036355 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004140 apolipoprotein A-I
References (Earliest) J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
(Latest) J:206959 Huang Y, et al., An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med. 2014 Feb;20(2):193-203
All references(235)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory