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Apoa1 Gene Detail
Summary
  • Symbol
    Apoa1
  • Name
    apolipoprotein A-I
  • Synonyms
    Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88049
    NCBI Gene: 11806
  • Gene Overview
    MyGene.info: APOA1
Location & Maps
more
  • Sequence Map
    Chr9:46228580-46230466 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1887 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM, cytoband A2-A4
  • Mapping Data
    69 experiments
Homology
more
  • Human Ortholog
    APOA1, apolipoprotein A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    APOA1, apolipoprotein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    apo(a)
  • Links
    NCBI Gene ID: 335
    neXtProt AC: NX_P02647

  • Chr Location
    11q23.3; chr11:116835751-116837647 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 47900
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: APOA1
  • Gene Tree
    Apoa1
Human Diseases
more
  • Diseases
    3 with human APOA1 associations

Human Disease Mouse Models
       Amyloidosis, Familial Visceral   OMIM: 105200
Apolipoprotein A-I; APOA1   OMIM: 107680
Hypoalphalipoproteinemia, Primary   OMIM: 604091
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 7 genetic backgrounds
    36 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    3
  • Genomic Mutations
    1 involving Apoa1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    50
  • Tissues
    15
  • cDNA Data
    1024
  • Literature Summary
    31
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028707 VEGA Gene Model | MGI Sequence Detail 1887 C57BL/6J ±  kb
transcript OTTMUST00000071093 VEGA | MGI Sequence Detail 1035 Not Applicable  
polypeptide OTTMUSP00000036355 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1036
    Genomic 5
    cDNA 1025
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639
References
more
  • Summaries
    All 238
    Developmental Gene Expression 31
    Diseases 3
    Gene Ontology 38
    Phenotypes 119
  • Earliest
    J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
  • Latest
    J:231194 Petropoulou PI, et al., Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2106-15
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory