Apoa1 MGI Mouse Gene Detail - MGI:88049

Apoa1 Gene Detail

Symbol

Apoa1
Name

apolipoprotein A-I
Synonyms

Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2

Feature Type

protein coding gene
IDs

MGI:88049
NCBI Gene: 11806
Gene Overview

MyGene.info: APOA1

Sequence Map

Chr9:46228580-46230466 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

1887 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 25.36 cM, cytoband A2-A4
Mapping Data

69 experiments

Human Ortholog

APOA1, apolipoprotein A1

Vertebrate Orthologs

11

Human Ortholog

APOA1, apolipoprotein A1
Orthology source: HomoloGene, HGNC
Synonyms

apo(a)
Links

HGNC:600

NCBI Gene ID: 335

neXtProt AC: NX_P02647

UniProt: P02647
Chr Location

11q23.3; chr11:116835751-116837950 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 47900
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: APOA1
Gene Tree

Apoa1

Diseases

1 with human APOA1 associations

				Human Disease	Mouse Models
				familial visceral amyloidosis IDs familial visceral amyloidosis DOID:0050636 OMIM:105200

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 4 alleles in 7 genetic backgrounds
36 phenotypes from multigenic genotypes
121 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

1
Targeted

6
Transgenic

3
Genomic Mutations

1 involving Apoa1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

9 strains or lines available

Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.

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All GO Annotations

132
GO References

38

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

50
Tissues

15
cDNA Data

1024
Literature Summary

31

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN apoa1a, apoa1b

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Apoa1 interacts with 10 markers (Mir147, Mir325, Mir471, ...) View All

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All Sequences

31
RefSeq

2
UniProt

4
CCDS

CCDS40610.1
UniGene

26743

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028707	VEGA Gene Model \| MGI Sequence Detail	1887	C57BL/6J	± kb
transcript	OTTMUST00000071093	VEGA \| MGI Sequence Detail	1035	Not Applicable
polypeptide	OTTMUSP00000036355	VEGA \| MGI Sequence Detail	264	Not Applicable

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SNPs within 2kb

64 from dbSNP Build 142

RFLP

1

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UniProt

4 Sequences
Protein Ontology

PR:000004140 apolipoprotein A-I

(term hierarchy)
PDB

2LEM
InterPro Domains

IPR000074 Apolipoprotein A/E

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All nucleic 1036

Genomic 5

cDNA 1025

Primer pair 5

Other 1

Microarray probesets 4

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MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639

Summaries

All 281

Developmental Gene Expression 31

Diseases 1

Gene Ontology 38

Phenotypes 121
Earliest

J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
Latest

J:237669 Ossoli A, et al., Plasma-derived and synthetic high-density lipoprotein inhibit tissue factor in endothelial cells and monocytes. Biochem J. 2016 Jan 15;473(2):211-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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