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Apoa1 Gene Detail
Summary
  • Symbol
    Apoa1
  • Name
    apolipoprotein A-I
  • Synonyms
    Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep2, Sep-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88049
    NCBI Gene: 11806
  • Gene Overview
    MyGene.info: APOA1
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46228630-46230469 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.36 cM, cytoband A2-A4
  • Mapping Data
    69 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88049
protein coding gene Chr9:46228580-46230469 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034748
protein coding gene Chr9:44858667-44860553 (+)
A/J MGP_AJ_G0034729
protein coding gene Chr9:43574365-43576263 (+)
AKR/J MGP_AKRJ_G0034656
protein coding gene Chr9:44462543-44464429 (+)
BALB/cJ MGP_BALBcJ_G0034720
protein coding gene Chr9:43295876-43297774 (+)
C3H/HeJ MGP_C3HHeJ_G0034431
protein coding gene Chr9:44936599-44938497 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035241
protein coding gene Chr9:46139445-46141331 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032155
protein coding gene Chr9:43105006-43106903 (+)
CAST/EiJ MGP_CASTEiJ_G0033753
protein coding gene Chr9:44794642-44796528 (+)
CBA/J MGP_CBAJ_G0034403
protein coding gene Chr9:47824679-47826577 (+)
DBA/2J MGP_DBA2J_G0034562
protein coding gene Chr9:43445649-43447547 (+)
FVB/NJ MGP_FVBNJ_G0034503
protein coding gene Chr9:42709404-42711302 (+)
LP/J MGP_LPJ_G0034643
protein coding gene Chr9:45177188-45179074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034547
protein coding gene Chr9:49573347-49575245 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035262
protein coding gene Chr9:44381663-44383549 (+)
PWK/PhJ MGP_PWKPhJ_G0033458
protein coding gene Chr9:43364635-43366521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033294
protein coding gene Chr9:44710282-44712143 (+)
WSB/EiJ MGP_WSBEiJ_G0033866
protein coding gene Chr9:44430654-44432545 (+)



Homology
more
  • Human Ortholog
    APOA1, apolipoprotein A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    APOA1, apolipoprotein A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    apo(a)
  • Links
    NCBI Gene ID: 335
    neXtProt AC: NX_P02647
    UniProt: P02647

  • Chr Location
    11q23.3; chr11:116835751-116837950 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 47900
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APOA1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human APOA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 6 genetic backgrounds
    38 phenotypes from multigenic genotypes
    125 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11806 NCBI Gene Model | MGI Sequence Detail 1840 C57BL/6J ±  kb
    transcript NM_009692 RefSeq | MGI Sequence Detail 988 C57BL/6  
    polypeptide Q00623 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1037
      Genomic 5
      cDNA 1026
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639
    References
    more
    • Summaries
      All 312
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 39
      Phenotypes 125
    • Earliest
      J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
    • Latest
      J:266131 Santander N, et al., Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure. BMC Genomics. 2018 Oct 5;19(1):731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory