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Fabp4 Gene Detail
Summary
  • Symbol
    Fabp4
  • Name
    fatty acid binding protein 4, adipocyte
  • Synonyms
    422/aP2, ALBP/Ap2, Ap2, Lbpl
  • Feature Type
    protein coding gene
  • IDs
    MGI:88038
    NCBI Gene: 11770
  • Gene Overview
    MyGene.info: FABP4
Location & Maps
more
  • Sequence Map
    Chr3:10204088-10208576 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4489 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.56 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    FABP4, fatty acid binding protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FABP4, fatty acid binding protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AFABP, A-FABP, ALBP, aP2, HEL-S-104
  • Links
    NCBI Gene ID: 2167
    neXtProt AC: NX_P15090

  • Chr Location
    8q21; chr8:81478497-81483238 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit susceptibility to diet-induced obesity, attenuated dibutyryl cAMP-induced adipocyte release of glycerol and free fatty acid, and reduced acute insulin secretion in response to beta-adrenergic stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051458 VEGA Gene Model | MGI Sequence Detail 4489 C57BL/6J ±  kb
transcript OTTMUST00000130031 VEGA | MGI Sequence Detail 896 Not Applicable  
polypeptide OTTMUSP00000069766 VEGA | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    113 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 252
    Genomic 8
    cDNA 237
    Primer pair 6
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1345, MGD-MRK-36068, MGI:107500
References
more
  • Summaries
    All 106
    Developmental Gene Expression 37
    Gene Ontology 8
    Phenotypes 33
  • Earliest
    J:7568 Bernlohr DA, et al., Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5468-72
  • Latest
    J:232408 Van De Pette M, et al., Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016 Mar;12(3):e1005916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory