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Fabp4
Gene Detail
Symbol

Name
ID
Fabp4
fatty acid binding protein 4, adipocyte
MGI:88038
Synonyms
422/aP2, ALBP/Ap2, Ap2, Lbpl
Feature Type
protein coding gene
Genetic Map
Chromosome 3
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:10204342-10208602 bp, - strand
From NCBI annotation of GRCm38

  4261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Fabp4

Human
homologs
Human Homolog FABP4, fatty acid binding protein 4, adipocyte
NCBI Gene ID 2167
neXtProt AC  NX_P15090
Human Synonyms  AFABP, A-FABP, ALBP, aP2, HEL-S-104
Human Chr (Location)  8q21; chr8:81478497-81483238 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit susceptibility to diet-induced obesity, attenuated dibutyryl cAMP-induced adipocyte release of glycerol and free fatty acid, and reduced acute insulin secretion in response to beta-adrenergic stimulation.
 
Interactions
Fabp4 interacts with 34 markers (Mir141, Mir142, Mir154, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process brown fat cell differentiation, cellular response to lithium ion, ...
Component cytoplasm, cytosol, ...
Function lipid binding, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (202)    Tissues (66)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 166
Northern blot 25
RT-PCR 9
cDNA source data(234)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(252) Genomic(8) cDNA(237) Primer pair(6) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000062515 (Evidence)
Entrez Gene11770 (Evidence)
UniGene582
DFCITC1572806, TC1587108, TC1587943
DoTSDT.537572, DT.94383239
NIA Mouse Gene IndexU023829
PDB1A2D, 1ACD, 1ADL, 1ALB, 1G7N, 1LIB, 1LIC, 1LID, 1LIE, 1LIF, 2ANS, 2Q9S, 3JSQ, 1A18, 1AB0, 1G74, 2QM9, 3HK1, 3JS1
Consensus CDS ProjectCCDS17238.1
International Mouse Knockout Project StatusFabp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11770 NCBI Gene Model | MGI Sequence Detail 4261 C57BL/6J ±  kb
transcript NM_024406 RefSeq | MGI Sequence Detail 646 C57BL/6 
polypeptide P04117 UniProt | EBI | MGI Sequence Detail 132 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(7) : PCR(5) RFLP(2) SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR000463 Cytosolic fatty-acid binding
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology PR:000007312 fatty acid-binding protein, adipocyte
Graphical View of Protein Domain Structure
References
(Earliest) J:7568 Bernlohr DA, et al., Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5468-72
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(96)
Other
accession IDs
MGD-MRK-1345, MGD-MRK-36068, MGI:107500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory