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Fabp4 Gene Detail
Summary
  • Symbol
    Fabp4
  • Name
    fatty acid binding protein 4, adipocyte
  • Synonyms
    422/aP2, ALBP/Ap2, Ap2, Lbpl
  • Feature Type
    protein coding gene
  • IDs
    MGI:88038
    NCBI Gene: 11770
  • Gene Overview
    MyGene.info: FABP4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:10204342-10208602 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.56 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88038
protein coding gene Chr3:10204088-10208602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027063
protein coding gene Chr3:7169881-7174369 (-)
A/J MGP_AJ_G0027027
protein coding gene Chr3:7331665-7336153 (-)
AKR/J MGP_AKRJ_G0026997
protein coding gene Chr3:7230330-7234818 (-)
BALB/cJ MGP_BALBcJ_G0027036
protein coding gene Chr3:7026749-7031237 (-)
C3H/HeJ MGP_C3HHeJ_G0026776
protein coding gene Chr3:7535921-7540409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027480
protein coding gene Chr3:7806753-7811241 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024842
protein coding gene Chr3:6210276-6214943 (-)
CAST/EiJ MGP_CASTEiJ_G0026234
protein coding gene Chr3:7558818-7563310 (-)
CBA/J MGP_CBAJ_G0026754
protein coding gene Chr3:7817419-7821907 (-)
DBA/2J MGP_DBA2J_G0026890
protein coding gene Chr3:6893937-6898426 (-)
FVB/NJ MGP_FVBNJ_G0026857
protein coding gene Chr3:6821749-6826237 (-)
LP/J MGP_LPJ_G0027000
protein coding gene Chr3:7692015-7696503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026878
protein coding gene Chr3:8842379-8846867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027540
protein coding gene Chr3:7092065-7096553 (-)
PWK/PhJ MGP_PWKPhJ_G0025969
protein coding gene Chr3:7121635-7126294 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025772
protein coding gene Chr3:7234214-7238755 (-)
WSB/EiJ MGP_WSBEiJ_G0026305
protein coding gene Chr3:7123169-7128987 (-)



Homology
more
  • Human Ortholog
    FABP4, fatty acid binding protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FABP4, fatty acid binding protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFABP, A-FABP, ALBP, aP2, HEL-S-104
  • Links
    NCBI Gene ID: 2167
    neXtProt AC: NX_P15090
    UniProt: P15090

  • Chr Location
    8q21.13; chr8:81478497-81483238 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit susceptibility to diet-induced obesity, attenuated dibutyryl cAMP-induced adipocyte release of glycerol and free fatty acid, and reduced acute insulin secretion in response to beta-adrenergic stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11770 NCBI Gene Model | MGI Sequence Detail 4261 C57BL/6J ±  kb
    transcript NM_024406 RefSeq | MGI Sequence Detail 696 C57BL/6  
    polypeptide P04117 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 253
      Genomic 8
      cDNA 238
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1345, MGD-MRK-36068, MGI:107500
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 45
      Gene Ontology 12
      Phenotypes 41
    • Earliest
      J:7568 Bernlohr DA, et al., Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5468-72
    • Latest
      J:266447 Zhang Y, et al., Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes. J Invest Dermatol. 2018 Sep;138(9):1925-1934

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory