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Fabp4
Gene Detail
 Symbol
Name
ID
Fabp4
fatty acid binding protein 4, adipocyte
MGI:88038
Synonyms 422/aP2, ALBP/Ap2, Ap2, Lbpl
Feature Type protein coding gene
Genetic Map
Chromosome 3
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:10204347-10208576 bp, - strand
From Ensembl annotation of GRCm38

  4230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Fabp4

Human
homologs
Human Homolog FABP4, fatty acid binding protein 4, adipocyte
NCBI Gene ID 2167
neXtProt AC  NX_P15090
Human Synonyms  AFABP, A-FABP, ALBP, aP2, HEL-S-104
Human Chr (Location)  8q21; chr8:81478497-81483238 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit susceptibility to diet-induced obesity, attenuated dibutyryl cAMP-induced adipocyte release of glycerol and free fatty acid, and reduced acute insulin secretion in response to beta-adrenergic stimulation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process brown fat cell differentiation, cellular response to lithium ion, ...
Component cytoplasm, cytosol, ...
Function lipid binding, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (202)    Tissues (65)    Images (47)
Theiler Stages: 19, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 166
Northern blot 25
RT-PCR 9
cDNA source data(234)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(252) Genomic(8) cDNA(237) Primer pair(6) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000062515 (Evidence)
Entrez Gene11770 (Evidence)
UniGene582
DFCITC1572806, TC1587108, TC1587943
DoTSDT.537572, DT.94383239
NIA Mouse Gene IndexU023829
PDB1A2D, 1ACD, 1ADL, 1ALB, 1G7N, 1LIB, 1LIC, 1LID, 1LIE, 1LIF, 2ANS, 2Q9S, 3JSQ, 1A18, 1AB0, 1G74, 2QM9, 3HK1, 3JS1
Consensus CDS ProjectCCDS17238.1
International Mouse Knockout Project StatusFabp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062515 Ensembl Gene Model | MGI Sequence Detail 4230 C57BL/6J ±  kb
transcript ENSMUST00000029041 Ensembl | MGI Sequence Detail 637 Not Applicable 
polypeptide ENSMUSP00000029041 Ensembl | MGI Sequence Detail 132 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(7) : PCR(5) RFLP(2) SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR000463 Cytosolic fatty-acid binding
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology PR:000007312 fatty acid-binding protein, adipocyte
References (Earliest) J:7568 Bernlohr DA, et al., Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5468-72
(Latest) J:209701 Syamsunarno MR, et al., A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One. 2013;8(11):e79386
All references(93)
Other
accession IDs
MGD-MRK-1345, MGD-MRK-36068, MGI:107500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory