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Aox1 Gene Detail
Summary
  • Symbol
    Aox1
  • Name
    aldehyde oxidase 1
  • Synonyms
    Aox-1, Aox2, Aox-2, MGC:13774, retinal oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88035
    NCBI Gene: 11761
  • Gene Overview
    MyGene.info: AOX1
Location & Maps
more
  • Sequence Map
    Chr1:58029931-58106413 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76483 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AOX1, aldehyde oxidase 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AOX1, aldehyde oxidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AO, AOH1
  • Links
    NCBI Gene ID: 316
    neXtProt AC: NX_Q06278

  • Chr Location
    2q33; chr2:200585952-200682241 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Aox1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029784 VEGA Gene Model | MGI Sequence Detail 76483 C57BL/6J ±  kb
transcript OTTMUST00000073919 VEGA | MGI Sequence Detail 4423 Not Applicable  
polypeptide OTTMUSP00000038321 VEGA | MGI Sequence Detail 1333 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    619 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004089 aldehyde oxidase
  • EC
  • InterPro Domains
    IPR002888 [2Fe-2S]-binding
    IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR014313 Aldehyde oxidase
    IPR016208 Aldehyde oxidase/xanthine dehydrogenase
    IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
    IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
    IPR012675 Beta-grasp domain
    IPR005107 CO dehydrogenase flavoprotein, C-terminal
    IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    IPR016166 FAD-binding, type 2
    IPR016167 FAD-binding, type 2, subdomain 1
    IPR002346 Molybdopterin dehydrogenase, FAD-binding
    IPR022407 Oxidoreductase, molybdopterin binding site
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1340, MGD-MRK-1341, MGD-MRK-1342, MGD-MRK-1343, MGI:2138173, MGI:2138181, MGI:88036
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:5024 Gluecksohn-Waelsch S, et al., Genetic variations of an oxidase in mammals. J Biol Chem. 1967 Mar 25;242(6):1271-3
  • Latest
    J:220143 Kamli MR, et al., Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1291-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory