About   Help   FAQ
Aox1 Gene Detail
Summary
  • Symbol
    Aox1
  • Name
    aldehyde oxidase 1
  • Synonyms
    Aox-1, Aox2, Aox-2, MGC:13774, retinal oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88035
    NCBI Gene: 11761
  • Gene Overview
    MyGene.info: AOX1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58029931-58106413 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.86 cM, cytoband C1-C2
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    619 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88035
protein coding gene Chr1:58029806-58106413 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016045
protein coding gene Chr1:57863978-57944970 (+)
A/J MGP_AJ_G0016028
protein coding gene Chr1:55851751-55929423 (+)
AKR/J MGP_AKRJ_G0015984
protein coding gene Chr1:57355382-57431736 (+)
BALB/cJ MGP_BALBcJ_G0015983
protein coding gene Chr1:55885826-55960764 (+)
C3H/HeJ MGP_C3HHeJ_G0015815
protein coding gene Chr1:57629137-57709134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016436
protein coding gene Chr1:60231857-60310903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014158
protein coding gene Chr1:51792925-51865573 (+)
CAST/EiJ MGP_CASTEiJ_G0015397
protein coding gene Chr1:56888566-56962619 (+)
CBA/J MGP_CBAJ_G0015787
protein coding gene Chr1:61979738-62063017 (+)
DBA/2J MGP_DBA2J_G0015888
protein coding gene Chr1:55258621-55333566 (+)
FVB/NJ MGP_FVBNJ_G0015890
protein coding gene Chr1:54594008-54669620 (+)
LP/J MGP_LPJ_G0015960
protein coding gene Chr1:58758582-58832993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015910
protein coding gene Chr1:64997591-65077819 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016483
protein coding gene Chr1:57341138-57419064 (+)
PWK/PhJ MGP_PWKPhJ_G0015183
protein coding gene Chr1:54630103-54714630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014964
protein coding gene Chr1:56919903-57005920 (+)
WSB/EiJ MGP_WSBEiJ_G0015460
protein coding gene Chr1:57015028-57098907 (+)



Homology
more
  • Human Ortholog
    AOX1, aldehyde oxidase 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AOX1, aldehyde oxidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AO, AOH1
  • Links
    NCBI Gene ID: 316
    neXtProt AC: NX_Q06278
    UniProt: Q06278

  • Chr Location
    2q33.1; chr2:200585952-200677064 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063558 Ensembl Gene Model | MGI Sequence Detail 76483 C57BL/6J ±  kb
transcript ENSMUST00000001027 Ensembl | MGI Sequence Detail 4423 Not Applicable  
polypeptide ENSMUSP00000001027 Ensembl | MGI Sequence Detail 1333 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR002888 [2Fe-2S]-binding
    IPR036884 [2Fe-2S]-binding domain superfamily
    IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
    IPR036010 2Fe-2S ferredoxin-like superfamily
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR014313 Aldehyde oxidase
    IPR016208 Aldehyde oxidase/xanthine dehydrogenase
    IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
    IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
    IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
    IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
    IPR005107 CO dehydrogenase flavoprotein, C-terminal
    IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
    IPR016166 FAD-binding domain, PCMH-type
    IPR036318 FAD-binding, type PCMH-like superfamily
    IPR002346 Molybdopterin dehydrogenase, FAD-binding
    IPR022407 Oxidoreductase, molybdopterin binding site
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1340, MGD-MRK-1341, MGD-MRK-1342, MGD-MRK-1343, MGI:2138173, MGI:2138181, MGI:88036
References
more
  • Summaries
    All 60
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:5024 Gluecksohn-Waelsch S, et al., Genetic variations of an oxidase in mammals. J Biol Chem. 1967 Mar 25;242(6):1271-3
  • Latest
    J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory