About   Help   FAQ
Aox1
Gene Detail
Symbol

Name
ID
Aox1
aldehyde oxidase 1
MGI:88035
Synonyms
Aox-1, Aox2, Aox-2, MGC:13774, retinal oxidase
Feature Type
protein coding gene
Genetic Map
Chromosome 1
28.86 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr1:58029931-58106413 bp, + strand
From VEGA annotation of GRCm38

  76483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AOX1
Protein SuperFamily: xanthine dehydrogenase
Gene Tree: Aox1

Human
homologs
AOX1, aldehyde oxidase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 316
neXtProt AC: NX_Q06278

Human Synonyms: AO, AOH1

Human Chr (Location): 2q33; chr2:200585952-200682241 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Aox1 interacts with 79 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process oxidation-reduction process
Component cytoplasm, extracellular exosome
Function 2 iron, 2 sulfur cluster binding, aldehyde oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aox1    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029784 (Evidence)
Ensembl Gene Model ENSMUSG00000063558 (Evidence)
Entrez Gene 11761 (Evidence)
UniGene 26787
DFCI TC1586059
DoTS DT.40151490, DT.40152617
NIA Mouse Gene Index U000301
EC 1.17.3.-, 1.2.3.1
Consensus CDS Project CCDS35575.1
International Mouse Phenotyping Consortium Status Aox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029784 VEGA Gene Model | MGI Sequence Detail 76483 C57BL/6J ±  kb
transcript OTTMUST00000073919 VEGA | MGI Sequence Detail 4423 Not Applicable 
polypeptide OTTMUSP00000038321 VEGA | MGI Sequence Detail 1333 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(632 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002888 [2Fe-2S]-binding
InterPro IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR014313 Aldehyde oxidase
InterPro IPR016208 Aldehyde oxidase/xanthine dehydrogenase
InterPro IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
InterPro IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
InterPro IPR012675 Beta-grasp domain
InterPro IPR005107 CO dehydrogenase flavoprotein, C-terminal
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR002346 Molybdopterin dehydrogenase, FAD-binding
InterPro IPR022407 Oxidoreductase, molybdopterin binding site
Protein Ontology PR:000004089 aldehyde oxidase
References
(Earliest) J:5024 Gluecksohn-Waelsch S, et al., Genetic variations of an oxidase in mammals. J Biol Chem. 1967 Mar 25;242(6):1271-3
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(53)
Other
accession IDs
MGD-MRK-1340, MGD-MRK-1341, MGD-MRK-1342, MGD-MRK-1343, MGI:2138173, MGI:2138181, MGI:88036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory