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Ank3
Gene Detail
Symbol

Name
ID
Ank3
ankyrin 3, epithelial
MGI:88026
Synonyms
2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
Feature Type
protein coding gene
Genetic Map
Chromosome 10
36.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:69533772-70027438 bp, + strand
From VEGA annotation of GRCm38

  493667 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ank3

Human
homologs
Human Homolog ANK3, ankyrin 3, node of Ranvier (ankyrin G)
NCBI Gene ID 288
neXtProt AC  NX_Q12955
Human Synonyms  ANKYRIN-G, MRT37
Human Chr (Location)  10q21; chr10:60026298-60733526 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANK3
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.
 
Interactions
Ank3 interacts with 433 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process axon guidance, axonogenesis, ...
Component axon, axon initial segment, ...
Function cadherin binding, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(146)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(157) cDNA(155) Primer pair(2)
Microarray probesets(9)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043361 VEGA Gene Model | MGI Sequence Detail 493667 C57BL/6J ±  kb
transcript OTTMUST00000124840 VEGA | MGI Sequence Detail 8612 Not Applicable 
polypeptide OTTMUSP00000067834 VEGA | MGI Sequence Detail 2871 Not Applicable 

For the selected sequences
All sequences(306) RefSeq(54) UniProt(50)
Polymorphisms
All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(3749 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000906 ZU5
Protein Ontology PR:000004035 ankyrin-3
References
(Earliest) J:14772 Peters LL, et al., Chromosomal location and tissue dependent alternative mRNA processing of murine Ank-3, a new member of the ankyrin gene family. Blood. 1992;80(10 Suppl 1):272a (Abstr.)
(Latest) J:214712 Le Bras B, et al., In vivo assembly of the axon initial segment in motor neurons. Brain Struct Funct. 2014 Jul;219(4):1433-50
All references(70)
Other
accession IDs
MGD-MRK-1326, MGD-MRK-1329, MGI:1920263, MGI:2143560

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory