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Ank3 Gene Detail
Summary
  • Symbol
    Ank3
  • Name
    ankyrin 3, epithelial
  • Synonyms
    2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88026
    NCBI Gene: 11735
  • Gene Overview
    MyGene.info: ANK3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:69533772-70027438 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      493667 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 36.10 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    ANK3, ankyrin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANK3, ankyrin 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANKYRIN-G, MRT37
  • Links
    NCBI Gene ID: 288
    neXtProt AC: NX_Q12955
    UniProt: Q12955

  • Chr Location
    10q21.2; chr10:60026298-60733526 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56908
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANK3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ANK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000043361 VEGA Gene Model | MGI Sequence Detail 493667 C57BL/6J ±  kb
    transcript OTTMUST00000124840 VEGA | MGI Sequence Detail 8612 Not Applicable  
    polypeptide OTTMUSP00000067834 VEGA | MGI Sequence Detail 2871 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4566 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      cDNA 157
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-1326, MGD-MRK-1329, MGI:1920263, MGI:2143560
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 13
      Gene Ontology 19
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261596 Schilders K, et al., Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res. 2018 Feb;27(1):75-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory