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Ank3 Gene Detail
Summary
  • Symbol
    Ank3
  • Name
    ankyrin 3, epithelial
  • Synonyms
    2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88026
    NCBI Gene: 11735
  • Gene Overview
    MyGene.info: ANK3
Location & Maps
more
  • Sequence Map
    Chr10:69533772-70027438 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      493667 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ANK3, ankyrin 3, node of Ranvier (ankyrin G)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANK3, ankyrin 3, node of Ranvier (ankyrin G)
    Orthology source: HomoloGene
  • Synonyms
    ANKYRIN-G, MRT37
  • Links
    NCBI Gene ID: 288
    neXtProt AC: NX_Q12955

  • Chr Location
    10q21; chr10:60026298-60733526 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56908
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ANK3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ANK3 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 37; MRT37   OMIM: 615493
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ank3
  • Incidental Mutations
Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043361 VEGA Gene Model | MGI Sequence Detail 493667 C57BL/6J ±  kb
transcript OTTMUST00000124840 VEGA | MGI Sequence Detail 8612 Not Applicable  
polypeptide OTTMUSP00000067834 VEGA | MGI Sequence Detail 2871 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4566 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 157
    cDNA 155
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-1326, MGD-MRK-1329, MGI:1920263, MGI:2143560
References
more
  • Summaries
    All 72
    Developmental Gene Expression 9
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:14772 Peters LL, et al., Chromosomal location and tissue dependent alternative mRNA processing of murine Ank-3, a new member of the ankyrin gene family. Blood. 1992;80(10 Suppl 1):272a (Abstr.)
  • Latest
    J:219896 Zhang A, et al., Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015 Feb 4;35(5):2246-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory