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Ank3
Gene Detail
 Symbol
Name
ID
Ank3
ankyrin 3, epithelial
MGI:88026
Synonyms 2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
Feature Type protein coding gene
Genetic Map
Chromosome 10
36.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:69533772-70027438 bp, + strand
From VEGA annotation of GRCm38

  493667 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ank3

Human
homologs
Human Homolog ANK3, ankyrin 3, node of Ranvier (ankyrin G)
NCBI Gene ID 288
neXtProt AC  NX_Q12955
Human Synonyms  ANKYRIN-G, MRT37
Human Chr (Location)  10q21; chr10:60026298-60733526 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANK3
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.
 
Interactions
Ank3 interacts with 433 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process axon guidance, axonogenesis, ...
Component axon, axon initial segment, ...
Function cadherin binding, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (2)    Tissues (2)    Images (2)
Theiler Stages: 11, 13
Assay TypeResults
RNA in situ 2
cDNA source data(146)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(157) cDNA(155) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000043361 (Evidence)
Ensembl Gene ModelENSMUSG00000069601 (Evidence)
Entrez Gene11735 (Evidence)
UniGene235960
DFCITC1578590, TC1584086, TC1592413, TC1597706, TC1599120, TC1601689, TC1604488, TC1606240, TC1614684, TC1626863, TC1635661
DoTSDT.101297485, DT.101386820, DT.101386821, DT.101737096, DT.482116, DT.531596, DT.55279211, DT.87047076, DT.91313498, DT.91330064, DT.91361960, DT.91404116, DT.91422796, DT.91570402, DT.94251727, DT.94256275, DT.94297757, DT.94339681, DT.97391197, DT.99808781, DT.99848201, DT.99848204, DT.99848792
NIA Mouse Gene IndexU011625
Consensus CDS ProjectCCDS23909.1, CCDS23910.1, CCDS23911.1, CCDS23912.1, CCDS35931.1, CCDS48590.1, CCDS59545.1, CCDS59546.1
International Mouse Knockout Project StatusAnk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043361 VEGA Gene Model | MGI Sequence Detail 493667 C57BL/6J ±  kb
transcript OTTMUST00000124840 VEGA | MGI Sequence Detail 8612 Not Applicable 
polypeptide OTTMUSP00000067834 VEGA | MGI Sequence Detail 2871 Not Applicable 

For the selected sequences
All sequences(282) RefSeq(54) UniProt(26)
Polymorphisms All PCR and RFLP(7) : PCR(2) RFLP(5) SNPs within 2kb(3749 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000906 ZU5
Protein Ontology PR:000004035 ankyrin-3
References (Earliest) J:14772 Peters LL, et al., Chromosomal location and tissue dependent alternative mRNA processing of murine Ank-3, a new member of the ankyrin gene family. Blood. 1992;80(10 Suppl 1):272a (Abstr.)
(Latest) J:198370 Jenkins PM, et al., E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. J Biol Chem. 2013 May 17;288(20):14018-31
All references(68)
Other
accession IDs
MGD-MRK-1326, MGD-MRK-1329, MGI:1920263, MGI:2143560

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory