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Amh Gene Detail
Summary
  • Symbol
    Amh
  • Name
    anti-Mullerian hormone
  • Synonyms
    MIS, Mullerian inhibiting substance
  • Feature Type
    protein coding gene
  • IDs
    MGI:88006
    NCBI Gene: 11705
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:80805243-80807648 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2406 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    AMH, anti-Mullerian hormone
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AMH, anti-Mullerian hormone
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MIF, MIS
  • Links
    NCBI Gene ID: 268
    neXtProt AC: NX_P03971
    UniProt: P03971

  • Chr Location
    19p13.3; chr19:2249114-2252073 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AMH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 7 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035262 Ensembl Gene Model | MGI Sequence Detail 2406 C57BL/6J ±  kb
    transcript ENSMUST00000036016 Ensembl | MGI Sequence Detail 1670 Not Applicable  
    polypeptide ENSMUSP00000043153 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      29 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 7
      cDNA 10
      Primer pair 10
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1297
    References
    more
    • Summaries
      All 257
      Developmental Gene Expression 187
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265083 Mullen RD, et al., Osterix functions downstream of anti-Mullerian hormone signaling to regulate Mullerian duct regression. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8382-8387

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory