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Amh
Gene Detail
 Symbol
Name
ID
Amh
anti-Mullerian hormone
MGI:88006
Synonyms MIS, Mullerian inhibiting substance
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr10:80805248-80807648 bp, + strand
From NCBI annotation of GRCm38

  2401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: Muellerian-inhibiting factor
Gene Tree: Amh

Human
homologs
Human Homolog AMH, anti-Mullerian hormone
NCBI Gene ID 268
neXtProt AC  NX_P03971
Human Synonyms  MIF, MIS
Human Chr (Location)  19p13.3; chr19:2249114-2252073 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMH
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process Mullerian duct regression, ovarian follicle development, ...
Component cytoplasm, extracellular region, ...
Function growth factor activity, receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (247)    Tissues (75)    Images (71)
Theiler Stages: 4, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 46
Northern blot 18
RT-PCR 108
RNase protection 46
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(9) Primer pair(8) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035262 (Evidence)
Entrez Gene11705 (Evidence)
UniGene376094
DFCITC1598501
DoTSDT.91304243
Consensus CDS ProjectCCDS24033.1
International Mouse Knockout Project StatusAmh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11705 NCBI Gene Model | MGI Sequence Detail 2401 C57BL/6J ±  kb
transcript NM_007445 RefSeq | MGI Sequence Detail 1665 C57BL/6 
polypeptide NP_031471 RefSeq | MGI Sequence Detail 554 C57BL/6 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms RFLP(6) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006799 Anti-Mullerian hormone, N-terminal
InterPro IPR021203 Muellerian-inhibiting factor
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
Protein Ontology PR:000000073 anti-Muellerian hormone
References (Earliest) J:11966 Womack JE, et al., Syntenic mapping of 37 loci in cattle. Chromosomal conservation with mouse and man. Cytogenet Cell Genet. 1989;51:1109
(Latest) J:204550 Fujimoto Y, et al., Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
All references(201)
Other
accession IDs
MGD-MRK-1297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory