Amh
Gene Detail

Symbol Name ID

Amh anti-Mullerian hormone MGI:88006

Synonyms

MIS, Mullerian inhibiting substance

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr10:80805248-80807648 bp, + strand From NCBI annotation of GRCm38   2401 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken

Protein SuperFamily: Muellerian-inhibiting factor
Gene Tree: Amh

Human homologs

Human Homolog		AMH, anti-Mullerian hormone
NCBI Gene ID		268
neXtProt AC		NX_P03971
Human Synonyms		MIF, MIS
Human Chr (Location)		19p13.3; chr19:2249113-2252072 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AMH

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	Mullerian duct regression, ovarian follicle development, ...
Component	cytoplasm, extracellular region, ...
Function	growth factor activity, receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (132 records)
Data Summary: Results (230)    Tissues (71)    Images (51)
Theiler Stages: 4, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	16
RNA in situ	41
Northern blot	18
RT-PCR	108
RNase protection	47

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(7) cDNA(8) Primer pair(8) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035262 (Evidence)
Entrez Gene	11705 (Evidence)
UniGene	376094
DFCI	TC1598501
DoTS	DT.91304243
Consensus CDS Project	CCDS24033.1
International Mouse Knockout Project Status	Amh

Sequences

Length	Strain/Species
genomic	11705	NCBI Gene Model | MGI Sequence Detail	2401	C57BL/6J
transcript	NM_007445	RefSeq | MGI Sequence Detail	1665	C57BL/6
polypeptide	NP_031471	RefSeq | MGI Sequence Detail	554	C57BL/6

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(6) : SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006799	Anti-Mullerian hormone, N-terminal
InterPro	IPR021203	Muellerian-inhibiting factor
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
Protein Ontology	PR:000000073	anti-Muellerian hormone

References

(Earliest) J:11966 Womack JE, et al., Syntenic mapping of 37 loci in cattle. Chromosomal conservation with mouse and man. Cytogenet Cell Genet. 1989;51:1109
(Latest) J:194924 Lavery R, et al., Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet. 2012;8(12):e1003170
All references(196)

Other accession IDs

MGD-MRK-1297