Amh MGI Mouse Gene Detail - MGI:88006 - anti-Mullerian hormone

Symbol

Amh
Name

anti-Mullerian hormone
Synonyms

MIS, Mullerian inhibiting substance

Feature Type

protein coding gene
IDs

MGI:88006
NCBI Gene: 11705
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr10:80641077-80643482 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

10 experiments

SNPs within 2kb

89 from dbSNP Build 142
Strain Annotations

19
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88006	protein coding gene	Chr10:80641074-80643513 (+)
129S1/SvImJ	ENSMUSG00200044085	protein coding gene	Chr10:77267365-77269770 (+)
A/J	ENSMUSG00195042024	protein coding gene	Chr10:77662934-77665339 (+)
AKR/J	ENSMUSG00220047651	protein coding gene	Chr10:77260627-77263032 (+)
BALB/cJ	ENSMUSG00180047286	protein coding gene	Chr10:77673409-77675814 (+)
C3H/HeJ	ENSMUSG00175046889	protein coding gene	Chr10:77544156-77546561 (+)
C57BL/6NJ	ENSMUSG00215052024	protein coding gene	Chr10:77286014-77288419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015603	protein coding gene	Chr10:74805996-74808388 (+)
CAST/EiJ	ENSTCUG00005048163	protein coding gene	Chr10:77171499-77173904 (+)
CBA/J	ENSMUSG00210045344	protein coding gene	Chr10:77400193-77402598 (+)
DBA/2J	ENSMUSG00185050302	protein coding gene	Chr10:77742622-77745027 (+)
FVB/NJ	ENSMUSG00205044902	protein coding gene	Chr10:77455421-77457826 (+)
JF1/MsJ	ENSUMUG00000053186	protein coding gene	Chr10:78973960-78976365 (+)
LP/J	ENSMUSG00230050060	protein coding gene	Chr10:79512253-79514658 (+)
NOD/ShiLtJ	ENSMUSG00190049892	protein coding gene	Chr10:77656343-77658748 (+)
NZO/HlLtJ	ENSMUSG00225050977	protein coding gene	Chr10:83798747-83801152 (+)
PWK/PhJ	ENSLUMG00010038745	protein coding gene	Chr10:77334328-77336733 (+)
SPRET/EiJ	ENSMSPG00010042629	protein coding gene	Chr10:78950351-78952759 (+)
WSB/EiJ	ENSIUOG00005044742	protein coding gene	Chr10:77360082-77362487 (+)

Human Ortholog

AMH, anti-Mullerian hormone

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMH, anti-Mullerian hormone
Synonyms

MIF, MIS
Links

HGNC:464

NCBI Gene ID: 268

UniProt: P03971
Chr Location

19p13.3; chr19:2249309-2252073 (+) GRCh38

MGI Vertebrate Homology

Amh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AMH
Protein SuperFamily

Muellerian-inhibiting_factor
Gene Tree

Amh

Diseases

3 with human AMH associations

				Human Disease	Mouse Models
				disorder of sexual development IDs disorder of sexual development DOID:1923 MESH:D012734 UMLS_CUI:C0036875
				ovarian carcinoma IDs ovarian carcinoma DOID:4001 EFO:0001075
				persistent Mullerian duct syndrome IDs persistent Mullerian duct syndrome DOID:0050791 MESH:C536665 NCI:C120188 OMIM:261550 UMLS_CUI:C1849930

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 7 alleles in 2 genetic backgrounds
11 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

14
Genomic Mutations

1 involving Amh
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles.

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All GO Annotations

33
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1286
Tissues

121
cDNA Data

9
Literature Summary

257

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMH

Xenbase amh

ZFIN amh

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS24033.1

Ensembl

ENSMUSG00000035262 (Evidence)
NCBI Gene

11705

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035262	Ensembl Gene Model \| MGI Sequence Detail	2406	C57BL/6J	± kb
transcript	ENSMUST00000036016	Ensembl \| MGI Sequence Detail	1670	Not Applicable
polypeptide	ENSMUSP00000043153	Ensembl \| MGI Sequence Detail	554	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000000073 anti-Muellerian hormone

(term hierarchy)
InterPro Domains

IPR006799 Anti-Mullerian hormone, N-terminal

IPR029034 Cystine-knot cytokine

IPR021203 Muellerian-inhibiting factor

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal
GlyGen

P27106 4 sites, 1 O-linked glycan (1 site)

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All nucleic 48

Genomic 7

cDNA 10

Primer pair 22

Other 9

Antibodies 23

Microarray probesets 3

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MGD-MRK-1297

Summaries

All 350

Developmental Gene Expression 257

Gene Ontology 14

Phenotypes 33
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:389270 Chen M, et al., Wt1 Is Required for the Regression of Mullerian Ducts in Male Mice by Inducing Wif1 and Osx Expression. Cell Prolif. 2026 Jul 14;:e70264

TSS for Amh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94614	Chr10:80639115-80639126 (+)	-1,956 bp
Tssr94615	Chr10:80639435-80639451 (+)	-1,634 bp
Tssr94616	Chr10:80639479-80639494 (+)	-1,590 bp
Tssr94617	Chr10:80639497-80639516 (+)	-1,570 bp
Tssr94618	Chr10:80639871-80639897 (+)	-1,193 bp
Tssr94619	Chr10:80639902-80639924 (+)	-1,164 bp
Tssr94620	Chr10:80639934-80639952 (+)	-1,134 bp
Tssr94621	Chr10:80639958-80639984 (+)	-1,106 bp
Tssr94622	Chr10:80640045-80640061 (+)	-1,024 bp
Tssr94623	Chr10:80640554-80640574 (+)	-513 bp
Tssr94624	Chr10:80641067-80641083 (+)	-2 bp
Tssr94625	Chr10:80641962-80641975 (+)	892 bp
Tssr94626	Chr10:80642233-80642244 (+)	1,162 bp
Tssr94627	Chr10:80642664-80642674 (+)	1,592 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24