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Amh
Gene Detail
Symbol

Name
ID
Amh
anti-Mullerian hormone
MGI:88006
Synonyms
MIS, Mullerian inhibiting substance
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr10:80805248-80807648 bp, + strand
From Ensembl annotation of GRCm38

  2401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: AMH
Protein SuperFamily: Muellerian-inhibiting factor
Gene Tree: Amh

Human
homologs
AMH, anti-Mullerian hormone
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 268
neXtProt AC: NX_P03971

Human Synonyms: MIF, MIS

Human Chr (Location): 19p13.3; chr19:2249114-2252073 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AMH

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell-cell signaling, Mullerian duct regression, ...
Component cytoplasm, extracellular space
Function hormone activity, receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (156 records)
Data Summary: Results (253)    Tissues (84)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 35
RNA in situ 46
Northern blot 18
RT-PCR 108
RNase protection 46
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AMH ZFIN amh    NEW 
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(9) Primer pair(8) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035262 (Evidence)
Entrez Gene 11705 (Evidence)
UniGene 376094
DFCI TC1598501
DoTS DT.91304243
Consensus CDS Project CCDS24033.1
International Mouse Phenotyping Consortium Status Amh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035262 Ensembl Gene Model | MGI Sequence Detail 2401 C57BL/6J ±  kb
transcript ENSMUST00000036016 Ensembl | MGI Sequence Detail 1665 Not Applicable 
polypeptide ENSMUSP00000043153 Ensembl | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006799 Anti-Mullerian hormone, N-terminal
InterPro IPR021203 Muellerian-inhibiting factor
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
Protein Ontology PR:000000073 anti-Muellerian hormone
References
(Earliest) J:48607 Guerrier D, et al., The persistent Mullerian duct syndrome: a molecular approach. J Clin Endocrinol Metab. 1989 Jan;68(1):46-52
(Latest) J:222626 McClelland KS, et al., Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145
All references(216)
Other
accession IDs
MGD-MRK-1297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory