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Alox15
Gene Detail
Symbol

Name
ID
Alox15
arachidonate 15-lipoxygenase
MGI:87997
Synonyms
12-LO, Alox12l, L-12LO
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:70344152-70352031 bp, - strand
From VEGA annotation of GRCm38

  7880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44935  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ALOX15
Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox15

Human
homologs
ALOX15, arachidonate 15-lipoxygenase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 246
neXtProt AC: NX_P16050

Human Synonyms: 12-LOX, 15-LOX-1, 15LOX-1

Human Chr (Location): 17p13.3; chr17:4630919-4641665 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Genomic Mutations involving Alox15 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia.
 
Interactions
Alox15 interacts with 73 markers (Mir23a, Mir23b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apoptotic cell clearance, arachidonic acid metabolic process, ...
Component cytoplasm, cytosol, ...
Function arachidonate 12-lipoxygenase activity, arachidonate 15-lipoxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (97)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006044 (Evidence)
Ensembl Gene Model ENSMUSG00000018924 (Evidence)
Entrez Gene 11687 (Evidence)
UniGene 4584
DFCI TC1586256, TC1593061
DoTS DT.101180723, DT.55165862
NIA Mouse Gene Index U033000
EC 1.13.11.31, 1.13.11.33
Consensus CDS Project CCDS24944.1
International Mouse Phenotyping Consortium Status Alox15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006044 VEGA Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
transcript OTTMUST00000013609 VEGA | MGI Sequence Detail 2409 Not Applicable 
polypeptide OTTMUSP00000006312 VEGA | MGI Sequence Detail 663 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR001885 Lipoxygenase, mammalian
Protein Ontology PR:000003959 arachidonate 15-lipoxygenase
References
(Earliest) J:18190 Chen XS, et al., cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994 May 13;269(19):13979-87
(Latest) J:222716 Lefevre L, et al., LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARgamma ligand synthesis. Nat Commun. 2015;6:6801
All references(111)
Other
accession IDs
MGD-MRK-1284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory