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Alox15
Gene Detail
Symbol

Name
ID
Alox15
arachidonate 15-lipoxygenase
MGI:87997
Synonyms
12-LO, Alox12l, L-12LO
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:70344152-70352031 bp, - strand
From VEGA annotation of GRCm38

  7880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44935  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox15

Human
homologs
Human Homolog ALOX15, arachidonate 15-lipoxygenase
NCBI Gene ID 246
neXtProt AC  NX_P16050
Human Synonyms  12-LOX, 15-LOX-1, 15LOX-1
Human Chr (Location)  17p13.3; chr17:4630919-4641665 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia.
 
Interactions
Alox15 interacts with 73 markers (Mir23a, Mir23b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apoptotic cell clearance, arachidonic acid metabolic process, ...
Component cytoplasm, cytosol, ...
Function arachidonate 12-lipoxygenase activity, arachidonate 15-lipoxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (97)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006044 (Evidence)
Ensembl Gene ModelENSMUSG00000018924 (Evidence)
Entrez Gene11687 (Evidence)
UniGene4584
DFCITC1593061, TC1586256
DoTSDT.55165862, DT.101180723
NIA Mouse Gene IndexU033000
EC1.13.11.33, 1.13.11.31
Consensus CDS ProjectCCDS24944.1
International Mouse Knockout Project StatusAlox15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006044 VEGA Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
transcript OTTMUST00000013609 VEGA | MGI Sequence Detail 2409 Not Applicable 
polypeptide OTTMUSP00000006312 VEGA | MGI Sequence Detail 663 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR001885 Lipoxygenase, mammalian
Protein Ontology PR:000003959 arachidonate 15-lipoxygenase
References
(Earliest) J:18190 Chen XS, et al., cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994 May 13;269(19):13979-87
(Latest) J:213640 Mayer-Barber KD, et al., Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature. 2014 Jul 3;511(7507):99-103
All references(107)
Other
accession IDs
MGD-MRK-1284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory