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Alox15 Gene Detail
Summary
  • Symbol
    Alox15
  • Name
    arachidonate 15-lipoxygenase
  • Synonyms
    12-LO, Alox12l, L-12LO
  • Feature Type
    protein coding gene
  • IDs
    MGI:87997
    NCBI Gene: 11687
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70234978-70242857 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87997
 protein coding gene Chr11:70234973-70279465 (-)
129S1/SvImJ ENSMUSG00200046173
 protein coding gene Chr11:67182010-67189889 (-)
A/J ENSMUSG00195035868
 protein coding gene Chr11:67208520-67216399 (-)
AKR/J ENSMUSG00220039127
 protein coding gene Chr11:67317519-67325399 (-)
BALB/cJ ENSMUSG00180053452
 protein coding gene Chr11:67277074-67284937 (-)
C3H/HeJ ENSMUSG00175053410
 protein coding gene Chr11:67227287-67235150 (-)
C57BL/6NJ ENSMUSG00215053776
 protein coding gene Chr11:67004424-67012304 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016628
 protein coding gene Chr11:65108543-65116473 (-)
CAST/EiJ ENSTCUG00005048144
 protein coding gene Chr11:66769414-66777394 (-)
CBA/J ENSMUSG00210054271
 protein coding gene Chr11:67081330-67089193 (-)
DBA/2J ENSMUSG00185041105
 protein coding gene Chr11:67285378-67293355 (-)
FVB/NJ ENSMUSG00205050118
 protein coding gene Chr11:67173352-67181316 (-)
JF1/MsJ ENSUMUG00000027371
 protein coding gene Chr11:67683896-67691874 (-)
LP/J ENSMUSG00230053374
 protein coding gene Chr11:68392321-68400200 (-)
NOD/ShiLtJ ENSMUSG00190053490
 protein coding gene Chr11:67311221-67319100 (-)
NZO/HlLtJ ENSMUSG00225045247
 protein coding gene Chr11:70573773-70581652 (-)
PWK/PhJ ENSLUMG00010040508
 protein coding gene Chr11:67190088-67198065 (-)
SPRET/EiJ ENSMSPG00010040165
 protein coding gene Chr11:67917075-67948481 (-)
WSB/EiJ ENSIUOG00005038546
 protein coding gene Chr11:67206178-67214066 (-)



Homology
more
  • Human Ortholog
    ALOX15, arachidonate 15-lipoxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALOX15, arachidonate 15-lipoxygenase
  • Synonyms
    12-LOX, 15-LOX, 15-LOX-1, LOG15
  • Links
    NCBI Gene ID: 246
    UniProt: P16050

  • Chr Location
    17p13.2; chr17:4630919-4642294 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    152 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    115
  • cDNA Data
    16
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018924 Ensembl Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
    transcript ENSMUST00000019068 Ensembl | MGI Sequence Detail 2409 Not Applicable  
    polypeptide ENSMUSP00000019068 Ensembl | MGI Sequence Detail 663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 16
      Primer pair 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1284
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 8
      Gene Ontology 21
      Phenotypes 152
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:386399 Asplund H, et al., Splenic erythrophagocytosis is regulated by ALX/FPR2 signaling. Haematologica. 2026 May 1;111(5):1759-1773
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory