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Aldoa Gene Detail
Summary
  • Symbol
    Aldoa
  • Name
    aldolase A, fructose-bisphosphate
  • Synonyms
    Aldo1, Aldo-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87994
    NCBI Gene: 11674
Location & Maps
more
  • Sequence Map
    Chr7:126795234-126800751 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5518 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ALDOA, aldolase, fructose-bisphosphate A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALDOA, aldolase, fructose-bisphosphate A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALDA, GSD12, HEL-S-87p
  • Links
    NCBI Gene ID: 226
    neXtProt AC: NX_P04075

  • Chr Location
    16p11.2; chr16:30053090-30070420 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ALDOA associations

Human Disease Mouse Models
       Glycogen Storage Disease Xii; GSD12   OMIM: 611881
Click on a disease name to see all genes associated with that disease.

  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    34
  • Gene trapped
    28
  • Targeted
    6
  • Genomic Mutations
    3 involving Aldoa
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025167 VEGA Gene Model | MGI Sequence Detail 5518 C57BL/6J ±  kb
transcript OTTMUST00000061918 VEGA | MGI Sequence Detail 1549 Not Applicable  
polypeptide OTTMUSP00000030465 VEGA | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    9 from dbSNP Build 137
Molecular
Reagents
less
  • All nucleic 1046
    Genomic 2
    cDNA 1042
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1276, MGD-MRK-1278
References
more
  • Summaries
    All 52
    Developmental Gene Expression 10
    Diseases 5
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:21434 Paolella G, et al., Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A. Eur J Biochem. 1986 Apr 15;156(2):229-35
  • Latest
    J:220330 Oppelt SA, et al., Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. Mol Genet Metab. 2015 Mar;114(3):445-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory