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Agtr2
Gene Detail
 Symbol
Name
ID
Agtr2
angiotensin II receptor, type 2
MGI:87966
Synonyms AT2 receptor
Feature Type protein coding gene
Genetic Map
Chromosome X
16.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
ChrX:21484544-21489164 bp, + strand
From VEGA annotation of GRCm38

  4621 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr2

Human
homologs
Human Homolog AGTR2, angiotensin II receptor, type 2
NCBI Gene ID 186
neXtProt AC  NX_P50052
Human Synonyms  AT2, ATGR2, MRX88
Human Chr (Location)  Xq22-q23; chrX:116170705-116174972 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele may exhibit abnormal response to angiotensin II, induced pancreatitis, and myocardial infarction; cardiovascular morphology and physiology; renal and urinary morphology and physiology; and glucose and lipid homeostasis.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process aldosterone secretion, angiotensin-activated signaling pathway, ...
Component integral component of membrane, intracellular, ...
Function angiotensin type II receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (69)    Tissues (46)    Images (13)
Theiler Stages: 19, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 31
Northern blot 23
RT-PCR 15
cDNA source data(42)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) Genomic(6) cDNA(42) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017210 (Evidence)
Ensembl Gene ModelENSMUSG00000068122 (Evidence)
Entrez Gene11609 (Evidence)
UniGene2679
DFCITC1574258
DoTSDT.40154773
NIA Mouse Gene IndexU019760
Consensus CDS ProjectCCDS40889.1
International Mouse Knockout Project StatusAgtr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017210 VEGA Gene Model | MGI Sequence Detail 4621 C57BL/6J ±  kb
transcript OTTMUST00000041678 VEGA | MGI Sequence Detail 3283 Not Applicable 
polypeptide OTTMUSP00000018718 VEGA | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000248 Angiotensin II receptor family
InterPro IPR000147 Angiotensin II receptor type 2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001191 angiotensin II receptor 2
References (Earliest) J:30921 Tsutsumi K, et al., Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol Pharmacol. 1992 Feb;41(2):290-7
(Latest) J:200118 Daugherty A, et al., PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism. PLoS One. 2013;8(4):e61849
All references(146)
Other
accession IDs
MGD-MRK-1197, MGI:2147867, MGI:2147996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory