Agtr2 MGI Mouse Gene Detail - MGI:87966 - angiotensin II receptor, type 2

Symbol

Agtr2
Name

angiotensin II receptor, type 2
Synonyms

AT2 receptor

Feature Type

protein coding gene
IDs

MGI:87966
NCBI Gene: 11609
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:21350863-21355072 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.71 cM
Mapping Data

15 experiments

SNPs within 2kb

16 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87966	protein coding gene	ChrX:21350783-21355403 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035608	protein coding gene	ChrX:16400450-16405070 (+)
A/J	MGP_AJ_G0035585	protein coding gene	ChrX:16497426-16502073 (+)
AKR/J	MGP_AKRJ_G0035518	protein coding gene	ChrX:17086053-17090674 (+)
BALB/cJ	MGP_BALBcJ_G0035578	protein coding gene	ChrX:16242330-16246950 (+)
C3H/HeJ	MGP_C3HHeJ_G0035296	protein coding gene	ChrX:16608000-16612620 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036114	protein coding gene	ChrX:16867860-16872480 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032978	protein coding gene	ChrX:14779244-14783891 (+)
CAST/EiJ	MGP_CASTEiJ_G0034587	protein coding gene	ChrX:15901034-15905653 (+)
CBA/J	MGP_CBAJ_G0035265	protein coding gene	ChrX:17621305-17625925 (+)
DBA/2J	MGP_DBA2J_G0035417	protein coding gene	ChrX:16311853-16316473 (+)
FVB/NJ	MGP_FVBNJ_G0035363	protein coding gene	ChrX:16192881-16197501 (+)
LP/J	MGP_LPJ_G0035499	protein coding gene	ChrX:16675597-16680217 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035407	protein coding gene	ChrX:17893807-17898427 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036121	protein coding gene	ChrX:16328235-16332855 (+)
PWK/PhJ	MGP_PWKPhJ_G0034288	protein coding gene	ChrX:15465662-15470281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034128	protein coding gene	ChrX:16339017-16343641 (+)
WSB/EiJ	MGP_WSBEiJ_G0034722	protein coding gene	ChrX:16185708-16190327 (+)

Human Ortholog

AGTR2, angiotensin II receptor type 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGTR2, angiotensin II receptor type 2
Synonyms

AT2, ATGR2, MRX88
Links

HGNC:338

NCBI Gene ID: 186

neXtProt AC: NX_P50052

UniProt: P50052
Chr Location

Xq23; chrX:116170744-116174974 (+) GRCh38

MGI Vertebrate Homology

Agtr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGTR2
Gene Tree

Agtr2

Diseases

5 with human AGTR2 associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783
				hypoglycemia IDs hypoglycemia DOID:9993 ICD10CM:E16.2 ICD9CM:251.2 MESH:D007003 NCI:C3126 UMLS_CUI:C0020615
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				intellectual disability IDs intellectual disability DOID:1059 NCI:C84392 UMLS_CUI:C0025362
				vesicoureteral reflux IDs vesicoureteral reflux DOID:9620 ICD10CM:N13.7 ICD9CM:593.7 MESH:D014718 NCI:C84467 OMIM:193000 OMIM:314550 OMIM:610878 OMIM:613674 OMIM:614317 OMIM:614318 OMIM:614319 OMIM:614674 OMIM:615390 OMIM:615963 ORDO:289365 UMLS_CUI:C0042580

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

103 phenotypes from 3 alleles in 8 genetic backgrounds
20 phenotypes from multigenic genotypes
1 images
110 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele may exhibit abnormal response to angiotensin II, induced pancreatitis, and myocardial infarction; cardiovascular morphology and physiology; renal and urinary morphology and physiology; and glucose and lipid homeostasis.

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All GO Annotations

56
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

157
cDNA Data

46
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGTR2

Xenbase agtr2

ZFIN agtr2

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS40889.1

Ensembl

ENSMUSG00000068122 (Evidence)
NCBI Gene

11609

			Length	Strain/Species	Flank
genomic	11609	NCBI Gene Model \| MGI Sequence Detail	4210	C57BL/6J	± kb
transcript	NM_007429	RefSeq \| MGI Sequence Detail	2872	ZRU/MplStud
polypeptide	P35374	UniProt \| EBI \| MGI Sequence Detail	363	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001191 angiotensin II receptor 2

(term hierarchy)
InterPro Domains

IPR000248 Angiotensin II receptor family

IPR000147 Angiotensin II receptor type 2

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 63

Genomic 6

cDNA 46

Primer pair 11

Microarray probesets 4

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MGD-MRK-1197, MGI:2147867, MGI:2147996

Summaries

All 214

Developmental Gene Expression 25

Diseases 1

Gene Ontology 15

Phenotypes 110
Earliest

J:30921 Tsutsumi K, et al., Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol Pharmacol. 1992 Feb;41(2):290-7
Latest

J:333852 Vieira TN, et al., Angiotensin type 2 receptor antagonism as a new target to manage gout. Inflammopharmacology. 2022 Dec;30(6):2399-2410

TSS for Agtr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160705	ChrX:21350771-21350786 (+)	-84 bp
Tssr160706	ChrX:21350800-21350812 (+)	-57 bp
Tssr160707	ChrX:21350846-21350877 (+)	-1 bp
Tssr160708	ChrX:21353548-21353574 (+)	2,698 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23