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Agtr2
Gene Detail
Symbol

Name
ID
Agtr2
angiotensin II receptor, type 2
MGI:87966
Synonyms
AT2 receptor
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
ChrX:21484544-21489164 bp, + strand
From VEGA annotation of GRCm38

  4621 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGTR2
Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr2

Human
homologs
AGTR2, angiotensin II receptor, type 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 186
neXtProt AC: NX_P50052

Human Synonyms: AT2, ATGR2, MRX88

Human Chr (Location): Xq22-q23; chrX:116170705-116174972 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele may exhibit abnormal response to angiotensin II, induced pancreatitis, and myocardial infarction; cardiovascular morphology and physiology; renal and urinary morphology and physiology; and glucose and lipid homeostasis.
 
Phenotype Images(1)
Interactions
Agtr2 interacts with 269 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (69)    Tissues (47)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Northern blot 23
RT-PCR 15
cDNA source data(42)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase agtr2 ; ZFIN agtr2    NEW 
Molecular
reagents
All nucleic(55) Genomic(6) cDNA(42) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017210 (Evidence)
Ensembl Gene Model ENSMUSG00000068122 (Evidence)
Entrez Gene 11609 (Evidence)
UniGene 2679
DFCI TC1574258
DoTS DT.40154773
NIA Mouse Gene Index U019760
Consensus CDS Project CCDS40889.1
International Mouse Phenotyping Consortium Status Agtr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017210 VEGA Gene Model | MGI Sequence Detail 4621 C57BL/6J ±  kb
transcript OTTMUST00000041678 VEGA | MGI Sequence Detail 3283 Not Applicable 
polypeptide OTTMUSP00000018718 VEGA | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000248 Angiotensin II receptor family
InterPro IPR000147 Angiotensin II receptor type 2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001191 angiotensin II receptor 2
References
(Earliest) J:30921 Tsutsumi K, et al., Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol Pharmacol. 1992 Feb;41(2):290-7
(Latest) J:218046 Cuffe JS, et al., The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
All references(151)
Other
accession IDs
MGD-MRK-1197, MGI:2147867, MGI:2147996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory