Agrn
Gene Detail

Symbol Name ID

Agrn agrin MGI:87961

Synonyms

Agrin, nmf380, NMF380

Feature Type

protein coding gene

Genetic Map

Chromosome 4

88.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:156165290-156185901 bp, - strand From VEGA annotation of GRCm38   20612 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:27907  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: agrin
Gene Tree: Agrn

Human homologs

Human Homolog		AGRN, agrin
NCBI Gene ID		375790
neXtProt AC		NX_O00468
Human Chr (Location)		1p36.33; chr1:955503-991499 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AGRN

Alleles and phenotypes

All alleles(13) : Targeted(5) Gene trapped(7) Chemically induced(1)
 

Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death.

 
Human Diseases Modeled Using Mouse Agrn (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	basal lamina, basement membrane, ...
Function	acetylcholine receptor regulator activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (57)    Tissues (21)    Images (13)
Theiler Stages: 17, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	18
Western blot	36

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(17) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000011080 (Evidence)
Ensembl Gene Model	ENSMUSG00000041936 (Evidence)
Entrez Gene	11603 (Evidence)
DFCI	TC1574714, TC1597868, TC1601048, TC1601749, TC1621503, TC1647471, TC1712317
DoTS	DT.101739055, DT.492497, DT.528497, DT.91387187, DT.91436257, DT.94291521, DT.94350853
NIA Mouse Gene Index	U025890
PDB	3PVE
Consensus CDS Project	CCDS19060.1
International Mouse Knockout Project Status	Agrn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011080	VEGA Gene Model | MGI Sequence Detail	20612	C57BL/6J
transcript	OTTMUST00000025918	VEGA | MGI Sequence Detail	7262	Not Applicable
polypeptide	OTTMUSP00000011875	VEGA | MGI Sequence Detail	1950	Not Applicable

All sequences(80) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(1) : SNPs(214 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004850	Agrin NtA
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR003645	Follistatin-like, N-terminal
InterPro	IPR011497	Kazal-type serine protease inhibitor domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR002350	Proteinase inhibitor I1, Kazal
InterPro	IPR000082	SEA
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000003845	agrin

References

(Earliest) J:3071 Rupp F, et al., Structure and chromosomal localization of the mammalian agrin gene. J Neurosci. 1992 Sep;12(9):3535-44
(Latest) J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
All references(108)

Other accession IDs

MGD-MRK-1190, MGI:3614576