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Gene Detail
adrenergic receptor kinase, beta 1
Synonyms Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1, GRK2
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.98 cM
Detailed Genetic Map ± 1 cM

Mapping data(8)
Sequence Map
Chr19:4286001-4306222 bp, - strand
From VEGA annotation of GRCm38

  20222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: beta-adrenergic-receptor kinase
Gene Tree: Adrbk1

Human Homolog ADRBK1, adrenergic, beta, receptor kinase 1
NCBI Gene ID 156
neXtProt AC  NX_P25098
Human Synonyms  BARK1, BETA-ARK1, GRK2
Human Chr (Location)  11q13.1; chr11:67266434-67286558 (+)  GRCh38
alleles, and
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.
Phenotype Images(1)
Adrbk1 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (52 annotations)
Process cardiac muscle contraction, desensitization of G-protein coupled receptor protein signaling pathway, ...
Component apical plasma membrane, axon, ...
Function ATP binding, beta-adrenergic receptor kinase activity, ...
External Resources: FuncBase
Literature Summary: (6 records)
Data Summary: Results (117)    Tissues (73)    Images (38)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 103
Northern blot 14
cDNA source data(125)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(130) Genomic(1) cDNA(127) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000035343 (Evidence)
Ensembl Gene ModelENSMUSG00000024858 (Evidence)
Entrez Gene110355 (Evidence)
DFCITC1575359, TC1622026, TC1646850
DoTSDT.101231533, DT.535368, DT.94375993
NIA Mouse Gene IndexU019093
Consensus CDS ProjectCCDS29426.1, CCDS70915.1
International Mouse Knockout Project StatusAdrbk1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035343 VEGA Gene Model | MGI Sequence Detail 20222 C57BL/6J ±  kb
transcript OTTMUST00000090208 VEGA | MGI Sequence Detail 3376 Not Applicable 
polypeptide OTTMUSP00000049443 VEGA | MGI Sequence Detail 689 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(57 from dbSNP Build 137)
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003791 beta-adrenergic receptor kinase 1
References (Earliest) J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
(Latest) J:204684 Rivas V, et al., Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest. 2013 Nov 1;123(11):4714-30
All references(89)
accession IDs
MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory