About   Help   FAQ
Adrbk1
Gene Detail
Symbol

Name
ID
Adrbk1
adrenergic receptor kinase, beta 1
MGI:87940
Synonyms
Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1, GRK2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:4286001-4306222 bp, - strand
From VEGA annotation of GRCm38

  20222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: ADRBK1
Protein SuperFamily: beta-adrenergic-receptor kinase
Gene Tree: Adrbk1

Human
homologs
ADRBK1, adrenergic, beta, receptor kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 156
neXtProt AC: NX_P25098

Human Synonyms: BARK1, BETA-ARK1, GRK2

Human Chr (Location): 11q13.1; chr11:67266400-67286558 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.
 
Phenotype Images(1)
Interactions
Adrbk1 interacts with 320 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (117)    Tissues (73)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 14
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(130) Genomic(1) cDNA(127) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035343 (Evidence)
Ensembl Gene Model ENSMUSG00000024858 (Evidence)
Entrez Gene 110355 (Evidence)
UniGene 254144
DFCI TC1575359, TC1622026, TC1646850
DoTS DT.101231533, DT.535368, DT.94375993
NIA Mouse Gene Index U019093
EC 2.7.11.15
Consensus CDS Project CCDS29426.1, CCDS70915.1
International Mouse Phenotyping Consortium Status Adrbk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035343 VEGA Gene Model | MGI Sequence Detail 20222 C57BL/6J ±  kb
transcript OTTMUST00000090208 VEGA | MGI Sequence Detail 3376 Not Applicable 
polypeptide OTTMUSP00000049443 VEGA | MGI Sequence Detail 689 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003791 beta-adrenergic receptor kinase 1
References
(Earliest) J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
(Latest) J:212993 Gao Y, et al., TGFBR1 is required for mouse myometrial development. Mol Endocrinol. 2014 Mar;28(3):380-94
All references(91)
Other
accession IDs
MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory