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Grk2 Gene Detail
Summary
  • Symbol
    Grk2
  • Name
    G protein-coupled receptor kinase 2
  • Synonyms
    Adrbk1, Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87940
    NCBI Gene: 110355
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:4286001-4306222 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20222 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.98 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    GRK2, G protein-coupled receptor kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GRK2, G protein-coupled receptor kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRBK1, BARK1, BETA-ARK1
  • Links
    NCBI Gene ID: 156
    neXtProt AC: NX_P25098
    UniProt: P25098

  • Chr Location
    11q13.2; chr11:67266420-67286558 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035343 VEGA Gene Model | MGI Sequence Detail 20222 C57BL/6J ±  kb
    transcript OTTMUST00000090208 VEGA | MGI Sequence Detail 3376 Not Applicable  
    polypeptide OTTMUSP00000049443 VEGA | MGI Sequence Detail 689 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      56 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 1
      cDNA 127
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 53
    • Earliest
      J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
    • Latest
      J:247008 Steury MD, et al., G-protein-coupled receptor kinase-2 is a critical regulator of TNFalpha signaling in colon epithelial cells. Biochem J. 2017 Jun 27;474(14):2301-2313

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory