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Grk2 Gene Detail
Summary
  • Symbol
    Grk2
  • Name
    G protein-coupled receptor kinase 2
  • Synonyms
    Adrbk1, Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87940
    NCBI Gene: 110355
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4286001-4306222 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.98 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87940
protein coding gene Chr19:4285999-4306222 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024661
protein coding gene Chr19:1140948-1166630 (-)
A/J MGP_AJ_G0024627
protein coding gene Chr19:1089684-1110806 (-)
AKR/J MGP_AKRJ_G0024600
protein coding gene Chr19:1118532-1138693 (-)
BALB/cJ MGP_BALBcJ_G0024627
protein coding gene Chr19:1079208-1100401 (-)
C3H/HeJ MGP_C3HHeJ_G0024395
protein coding gene Chr19:1117414-1139367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025075
protein coding gene Chr19:1184391-1208657 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022504
protein coding gene Chr19:1027912-1048067 (-)
CAST/EiJ MGP_CASTEiJ_G0023867
protein coding gene Chr19:1128186-1148233 (-)
CBA/J MGP_CBAJ_G0024366
protein coding gene Chr19:1244633-1268130 (-)
DBA/2J MGP_DBA2J_G0024494
protein coding gene Chr19:1050481-1070730 (-)
FVB/NJ MGP_FVBNJ_G0024461
protein coding gene Chr19:1060172-1083832 (-)
LP/J MGP_LPJ_G0024580
protein coding gene Chr19:1144255-1169170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024491
protein coding gene Chr19:1181830-1205245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025122
protein coding gene Chr19:1117508-1142141 (-)
PWK/PhJ MGP_PWKPhJ_G0023613
protein coding gene Chr19:1104804-1125639 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023418
protein coding gene Chr19:1100527-1120480 (-)
WSB/EiJ MGP_WSBEiJ_G0023929
protein coding gene Chr19:1111786-1134013 (-)



Homology
more
  • Human Ortholog
    GRK2, G protein-coupled receptor kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GRK2, G protein-coupled receptor kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRBK1, BARK1, BETA-ARK1
  • Links
    NCBI Gene ID: 156
    neXtProt AC: NX_P25098
    UniProt: P25098

  • Chr Location
    11q13.2; chr11:67266420-67286558 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024858 Ensembl Gene Model | MGI Sequence Detail 20222 C57BL/6J ±  kb
    transcript ENSMUST00000088737 Ensembl | MGI Sequence Detail 3376 Not Applicable  
    polypeptide ENSMUSP00000086114 Ensembl | MGI Sequence Detail 689 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 2
      cDNA 127
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 58
    • Earliest
      J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
    • Latest
      J:263790 Franco A, et al., G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. J Mol Cell Cardiol. 2018 Jun 30;121:60-68

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory