Adrbk1
Gene Detail

Symbol Name ID

Adrbk1 adrenergic receptor kinase, beta 1 MGI:87940

Synonyms

Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1, GRK2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr19:4286001-4306222 bp, - strand From VEGA annotation of GRCm38   20222 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: beta-adrenergic-receptor kinase
Gene Tree: Adrbk1

Human homologs

Human Homolog		ADRBK1, adrenergic, beta, receptor kinase 1
NCBI Gene ID		156
neXtProt AC		NX_P25098
Human Synonyms		BARK1, BETA-ARK1, GRK2
Human Chr (Location)		11q13.1; chr11:67033905-67054029 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(11)
 

Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	cardiac muscle contraction, desensitization of G-protein coupled receptor protein signaling pathway, ...
Component	apical plasma membrane, axon, ...
Function	ATP binding, beta-adrenergic receptor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (117)    Tissues (73)    Images (38)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	103
Northern blot	14

cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(130) Genomic(1) cDNA(127) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035343 (Evidence)
Ensembl Gene Model	ENSMUSG00000024858 (Evidence)
Entrez Gene	110355 (Evidence)
UniGene	254144
DFCI	TC1575359, TC1622026, TC1646850
DoTS	DT.101231533, DT.535368, DT.94375993
NIA Mouse Gene Index	U019093
EC	2.7.11.15
Consensus CDS Project	CCDS29426.1
International Mouse Knockout Project Status	Adrbk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035343	VEGA Gene Model | MGI Sequence Detail	20222	C57BL/6J
transcript	OTTMUST00000090208	VEGA | MGI Sequence Detail	3376	Not Applicable
polypeptide	OTTMUSP00000049443	VEGA | MGI Sequence Detail	689	Not Applicable

All sequences(70) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000239	GPCR kinase
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003791	beta-adrenergic receptor kinase 1

References

(Earliest) J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
(Latest) J:187717 Daigle TL, et al., Elimination of GRK2 from Cholinergic Neurons Reduces Behavioral Sensitivity to Muscarinic Receptor Activation. J Neurosci. 2012 Aug 15;32(33):11461-6
All references(84)

Other accession IDs

MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496