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Adrbk1 Gene Detail
Summary
  • Symbol
    Adrbk1
  • Name
    adrenergic receptor kinase, beta 1
  • Synonyms
    Adrbk-1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, betaARK1, beta ARK1, beta-AR kinase-1, GRK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87940
    NCBI Gene: 110355
Location & Maps
more
  • Sequence Map
    Chr19:4286001-4306222 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20222 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADRBK1, adrenergic, beta, receptor kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADRBK1, adrenergic, beta, receptor kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BARK1, BETA-ARK1, GRK2
  • Links
    NCBI Gene ID: 156
    neXtProt AC: NX_P25098

  • Chr Location
    11q13.1; chr11:67266400-67286558 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    11
  • Targeted
    4
  • Transgenic
    2
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035343 VEGA Gene Model | MGI Sequence Detail 20222 C57BL/6J ±  kb
transcript OTTMUST00000090208 VEGA | MGI Sequence Detail 3376 Not Applicable  
polypeptide OTTMUSP00000049443 VEGA | MGI Sequence Detail 689 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 130
    Genomic 1
    cDNA 127
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496
References
more
  • Summaries
    All 89
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 45
  • Earliest
    J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
  • Latest
    J:212993 Gao Y, et al., TGFBR1 is required for mouse myometrial development. Mol Endocrinol. 2014 Mar;28(3):380-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory