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Adrb3
Gene Detail
 Symbol
Name
ID
Adrb3
adrenergic receptor, beta 3
MGI:87939
Synonyms Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor, beta 3-AR, Beta-3 AR
Feature Type protein coding gene
Genetic Map
Chromosome 8
15.94 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:27225776-27229588 bp, - strand
From VEGA annotation of GRCm38

  3813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb3

Human
homologs
Human Homolog ADRB3, adrenoceptor beta 3
NCBI Gene ID 155
neXtProt AC  NX_P13945
Human Synonyms  BETA3AR
Human Chr (Location)  8p12; chr8:37962995-37966666 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADRB3
Alleles
and
phenotypes
All alleles(13) : Targeted(3) Gene trapped(10)
 
Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process activation of adenylate cyclase activity, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function adrenergic receptor activity, beta3-adrenergic receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (58)    Tissues (37)    Images (15)
Theiler Stages: 3, 4, 5, 19, 23, 28
Assay TypeResults
RNA in situ 42
RT-PCR 16
cDNA source data(13)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(13) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028657 (Evidence)
Ensembl Gene ModelENSMUSG00000031489 (Evidence)
Entrez Gene11556 (Evidence)
UniGene278475
DFCITC1584849
DoTSDT.110907547, DT.484228, DT.485819
NIA Mouse Gene IndexU029687
Consensus CDS ProjectCCDS22213.1
International Mouse Knockout Project StatusAdrb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028657 VEGA Gene Model | MGI Sequence Detail 3813 C57BL/6J ±  kb
transcript OTTMUST00000070996 VEGA | MGI Sequence Detail 1336 Not Applicable 
polypeptide OTTMUSP00000036280 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(7) UniProt(3)
Polymorphisms SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000681 Adrenergic receptor beta 3
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001194 beta-3 adrenergic receptor
References (Earliest) J:1532 Nahmias C, et al., Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991 Dec;10(12):3721-7
(Latest) J:203813 Fujikawa T, et al., Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013 Sep 3;18(3):431-44
All references(101)
Other
accession IDs
MGD-MRK-1145, MGD-MRK-1148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory