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Adrb3 Gene Detail
Summary
  • Symbol
    Adrb3
  • Name
    adrenergic receptor, beta 3
  • Synonyms
    Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor, beta 3-AR, Beta-3 AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87939
    NCBI Gene: 11556
  • Gene Overview
    MyGene.info: ADRB3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27225776-27230807 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 15.94 cM, cytoband A2-A4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87939
protein coding gene Chr8:27225776-27250616 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033505
protein coding gene Chr8:25420886-25424698 (-)
A/J MGP_AJ_G0033485
protein coding gene Chr8:24446709-24450521 (-)
AKR/J MGP_AKRJ_G0033410
protein coding gene Chr8:25272971-25276788 (-)
BALB/cJ MGP_BALBcJ_G0033481
protein coding gene Chr8:24616266-24620078 (-)
C3H/HeJ MGP_C3HHeJ_G0033195
protein coding gene Chr8:25478007-25481844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033997
protein coding gene Chr8:26397293-26401105 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030947
protein coding gene Chr8:21698659-21702516 (-)
CAST/EiJ MGP_CASTEiJ_G0032521
protein coding gene Chr8:24972352-24976168 (-)
CBA/J MGP_CBAJ_G0033170
protein coding gene Chr8:27445834-27449646 (-)
DBA/2J MGP_DBA2J_G0033325
protein coding gene Chr8:24416224-24420517 (-)
FVB/NJ MGP_FVBNJ_G0033269
protein coding gene Chr8:24227012-24230824 (-)
LP/J MGP_LPJ_G0033414
protein coding gene Chr8:25375030-25378842 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033312
protein coding gene Chr8:26883091-26886903 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034016
protein coding gene Chr8:25242061-25245878 (-)
PWK/PhJ MGP_PWKPhJ_G0032232
protein coding gene Chr8:24078350-24082170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032066
protein coding gene Chr8:24623069-24626905 (-)
WSB/EiJ MGP_WSBEiJ_G0032637
protein coding gene Chr8:25429976-25433802 (-)



Homology
more
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BETA3AR
  • Links
    NCBI Gene ID: 155
    neXtProt AC: NX_P13945
    UniProt: P13945

  • Chr Location
    8p11.23; chr8:37962995-37966666 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ADRB3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11556 NCBI Gene Model | MGI Sequence Detail 5032 C57BL/6J ±  kb
    transcript NM_013462 RefSeq | MGI Sequence Detail 2795 C57BL/6  
    polypeptide P25962 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 6
      cDNA 13
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1145, MGD-MRK-1148
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 59
    • Earliest
      J:1532 Nahmias C, et al., Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991 Dec;10(12):3721-7
    • Latest
      J:262992 Zhuang L, et al., Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory