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Adrb3
Gene Detail
Symbol

Name
ID
Adrb3
adrenergic receptor, beta 3
MGI:87939
Synonyms
Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor, beta 3-AR, Beta-3 AR
Feature Type
protein coding gene
Genetic Map
Chromosome 8
15.94 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:27225776-27229588 bp, - strand
From VEGA annotation of GRCm38

  3813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADRB3
Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb3

Human
homologs
ADRB3, adrenoceptor beta 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 155
neXtProt AC: NX_P13945

Human Synonyms: BETA3AR

Human Chr (Location): 8p12; chr8:37962995-37966666 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADRB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Adrb3 interacts with 128 markers (Mir24-1, Mir24-2, Mir25, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (34)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
RT-PCR 10
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN adrb3a, adrb3b    NEW 
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(13) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028657 (Evidence)
Ensembl Gene Model ENSMUSG00000031489 (Evidence)
Entrez Gene 11556 (Evidence)
UniGene 278475
DFCI TC1584849
DoTS DT.110907547, DT.484228, DT.485819
NIA Mouse Gene Index U029687
Consensus CDS Project CCDS22213.1
International Mouse Phenotyping Consortium Status Adrb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028657 VEGA Gene Model | MGI Sequence Detail 3813 C57BL/6J ±  kb
transcript OTTMUST00000070996 VEGA | MGI Sequence Detail 1336 Not Applicable 
polypeptide OTTMUSP00000036280 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000681 Adrenergic receptor beta 3
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001194 beta-3 adrenergic receptor
References
(Earliest) J:1532 Nahmias C, et al., Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991 Dec;10(12):3721-7
(Latest) J:217117 Arranz L, et al., Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 7;512(7512):78-81
All references(100)
Other
accession IDs
MGD-MRK-1145, MGD-MRK-1148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory