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Adrb3 Gene Detail
Summary
  • Symbol
    Adrb3
  • Name
    adrenergic receptor, beta 3
  • Synonyms
    Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor, beta 3-AR, Beta-3 AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87939
    NCBI Gene: 11556
  • Gene Overview
    MyGene.info: ADRB3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:27225776-27250616 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24841 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 15.94 cM, cytoband A2-A4
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADRB3, adrenoceptor beta 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BETA3AR
  • Links
    NCBI Gene ID: 155
    neXtProt AC: NX_P13945
    UniProt: P13945

  • Chr Location
    8p11.23; chr8:37962995-37966666 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ADRB3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations develop greater adiposity, especially on a high-fat diet, and are unresponsive to the beta3-adrenergic receptor agonist, CL316,243.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028657 VEGA Gene Model | MGI Sequence Detail 24841 C57BL/6J ±  kb
    transcript OTTMUST00000070996 VEGA | MGI Sequence Detail 1336 Not Applicable  
    polypeptide OTTMUSP00000036280 VEGA | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      146 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 6
      cDNA 13
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1145, MGD-MRK-1148
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 57
    • Earliest
      J:1532 Nahmias C, et al., Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 1991 Dec;10(12):3721-7
    • Latest
      J:260521 Masand R, et al., Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018 Mar 6;27(3):616-629.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory