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Adrb1 Gene Detail
Summary
  • Symbol
    Adrb1
  • Name
    adrenergic receptor, beta 1
  • Synonyms
    Adrb-1, beta 1-AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87937
    NCBI Gene: 11554
Location & Maps
more
  • Sequence Map
    Chr19:56722372-56724862 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2491 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
    Orthology source: HomoloGene
  • Synonyms
    ADRB1R, B1AR, BETA1AR, RHR
  • Links
    NCBI Gene ID: 153
    neXtProt AC: NX_P08588

  • Chr Location
    10q25.3; chr10:114044047-114046908 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ADRB1 associations

Human Disease Mouse Models
       Beta-1-Adrenergic Receptor; ADRB1   OMIM: 109630
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11554 NCBI Gene Model | MGI Sequence Detail 2491 C57BL/6J ±  kb
transcript NM_007419 RefSeq | MGI Sequence Detail 2491 C57BL/6  
polypeptide P34971 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 5
    cDNA 13
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1143, MGD-MRK-1146
References
more
  • Summaries
    All 116
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 15
    Phenotypes 49
  • Earliest
    J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
  • Latest
    J:223096 Yang X, et al., Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 2;116(1):e1-e10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory