Adrb1
Gene Detail

Symbol Name ID

Adrb1 adrenergic receptor, beta 1 MGI:87937

Synonyms

Adrb-1, beta 1-AR

Feature Type

protein coding gene

Genetic Map

Chromosome 19

51.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr19:56722372-56724862 bp, + strand From NCBI annotation of GRCm38   2491 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb1

Human homologs

Human Homolog		ADRB1, adrenoceptor beta 1
NCBI Gene ID		153
neXtProt AC		NX_P08588
Human Synonyms		ADRB1R, B1AR, BETA1AR, RHR
Human Chr (Location)		10q25.3; chr10:114044047-114046908 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ADRB1

Alleles and phenotypes

All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, early endosome, ...
Function	adrenergic receptor activity, alpha-2A adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (61)    Tissues (57)    Images (1)
Theiler Stages: 3, 4, 5, 12, 14, 18, 21, 23, 25, 28

Assay Type	Results
RT-PCR	61

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(5) cDNA(13) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035283 (Evidence)
Entrez Gene	11554 (Evidence)
UniGene	46797
DFCI	TC1599167
DoTS	DT.40154163
NIA Mouse Gene Index	U019602
Consensus CDS Project	CCDS29919.1
International Mouse Knockout Project Status	Adrb1

Sequences

Length	Strain/Species
genomic	11554	NCBI Gene Model | MGI Sequence Detail	2491	C57BL/6J
transcript	NM_007419	RefSeq | MGI Sequence Detail	2491	C57BL/6
polypeptide	P34971	UniProt | EBI | MGI Sequence Detail	466	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(5) : SNPs within 2kb(13 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002233	Adrenergic receptor
InterPro	IPR000507	Adrenergic receptor beta 1
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001192	beta-1 adrenergic receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:204379 Jiang Y, et al., beta2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. PLoS One. 2013;8(7):e70555
All references(113)

Other accession IDs

MGD-MRK-1143, MGD-MRK-1146