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Adrb1 Gene Detail
Summary
  • Symbol
    Adrb1
  • Name
    adrenergic receptor, beta 1
  • Synonyms
    Adrb-1, beta 1-AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87937
    NCBI Gene: 11554
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56710549-56713582 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.96 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87937
 protein coding gene Chr19:56710549-56721545 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025267
 protein coding gene Chr19:57094104-57096591 (+)
A/J MGP_AJ_G0025243
 protein coding gene Chr19:54269567-54272051 (+)
AKR/J MGP_AKRJ_G0025212
 protein coding gene Chr19:55987898-55990386 (+)
BALB/cJ MGP_BALBcJ_G0025238
 protein coding gene Chr19:54347583-54350068 (+)
C3H/HeJ MGP_C3HHeJ_G0024998
 protein coding gene Chr19:56220065-56222552 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025681
 protein coding gene Chr19:58469178-58473439 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023093
 protein coding gene Chr19:53193068-53195550 (+)
CAST/EiJ MGP_CASTEiJ_G0024463
 protein coding gene Chr19:56251753-56254233 (+)
CBA/J MGP_CBAJ_G0024978
 protein coding gene Chr19:61371104-61373591 (+)
DBA/2J MGP_DBA2J_G0025110
 protein coding gene Chr19:54056530-54059017 (+)
FVB/NJ MGP_FVBNJ_G0025071
 protein coding gene Chr19:53761416-53763904 (+)
LP/J MGP_LPJ_G0025196
 protein coding gene Chr19:56954429-56956916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025104
 protein coding gene Chr19:60636200-60638686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025739
 protein coding gene Chr19:56191427-56193917 (+)
PWK/PhJ MGP_PWKPhJ_G0024211
 protein coding gene Chr19:54023993-54026471 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024014
 protein coding gene Chr19:54871429-54873908 (+)
WSB/EiJ MGP_WSBEiJ_G0024533
 protein coding gene Chr19:56329183-56333219 (+)



Homology
more
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
  • Synonyms
    ADRB1R, B1AR, BETA1AR, FNSS2, RHR
  • Links
    NCBI Gene ID: 153
    neXtProt AC: NX_P08588
    UniProt: P08588

  • Chr Location
    10q25.3; chr10:114044047-114046908 (+)  GRCh38.p7
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    34 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    59
  • cDNA Data
    13
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11554 NCBI Gene Model | MGI Sequence Detail 3034 C57BL/6J ±  kb
    transcript NM_007419 RefSeq | MGI Sequence Detail 3034 C57BL/6  
    polypeptide P34971 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 5
      cDNA 14
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1143, MGD-MRK-1146
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 19
      Phenotypes 92
    • Earliest
      J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
    • Latest
      J:321449 Paulo E, et al., Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism. Cell Rep. 2021 Sep 21;36(12):109742
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/28/2022
    MGI 6.20     		The Jackson Laboratory