Adrb1
Gene Detail

Symbol

Name
ID

Adrb1
adrenergic receptor, beta 1
MGI:87937

Synonyms

Adrb-1, beta 1-AR

Feature Type

protein coding gene

Genetic Map

Chromosome 19
51.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr19:56722372-56724862 bp, + strand From NCBI annotation of GRCm38   2491 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb1

Human
homologs

Human Homolog		ADRB1, adrenoceptor beta 1
NCBI Gene ID		153
neXtProt AC		NX_P08588
Human Synonyms		ADRB1R, B1AR, BETA1AR, RHR
Human Chr (Location)		10q25.3; chr10:114044047-114046908 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ADRB1

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.

 
Mutations Annotated to Human Diseases (1)   

Interactions

Adrb1 interacts with 164 markers (Mir1b, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (72 annotations)

Process	adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, early endosome, ...
Function	adrenergic receptor activity, alpha-2A adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (58)    Tissues (55)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	58

cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(21) Genomic(5) cDNA(13) Primer pair(3)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000035283 (Evidence)
Entrez Gene	11554 (Evidence)
UniGene	46797
DFCI	TC1599167
DoTS	DT.40154163
NIA Mouse Gene Index	U019602
Consensus CDS Project	CCDS29919.1
International Mouse Knockout Project Status	Adrb1

Sequences

Length	Strain/Species
genomic	11554	NCBI Gene Model | MGI Sequence Detail	2491	C57BL/6J
transcript	NM_007419	RefSeq | MGI Sequence Detail	2491	C57BL/6
polypeptide	P34971	UniProt | EBI | MGI Sequence Detail	466	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(5) : SNPs within 2kb(13 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002233	Adrenergic receptor
InterPro	IPR000507	Adrenergic receptor beta 1
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001192	beta-1 adrenergic receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:215007 Davel AP, et al., Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Gialpha-coupled beta2-adrenoceptor signaling pathway. PLoS One. 2014;9(3):e91877
All references(115)

Other
accession IDs

MGD-MRK-1143, MGD-MRK-1146