Adrb1 MGI Mouse Gene Detail - MGI:87937 - adrenergic receptor, beta 1

Symbol

Adrb1
Name

adrenergic receptor, beta 1
Synonyms

Adrb-1, beta 1-AR

Feature Type

protein coding gene
IDs

MGI:87937
NCBI Gene: 11554
Gene Overview

MyGene.info: ADRB1
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:56722372-56724862 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.96 cM
Mapping Data

14 experiments

SNPs within 2kb

13 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87937	protein coding gene	Chr19:56722372-56724862 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0025267	protein coding gene	Chr19:57094104-57096591 (+)
A/J	MGP_AJ_G0025243	protein coding gene	Chr19:54269567-54272051 (+)
AKR/J	MGP_AKRJ_G0025212	protein coding gene	Chr19:55987898-55990386 (+)
BALB/cJ	MGP_BALBcJ_G0025238	protein coding gene	Chr19:54347583-54350068 (+)
C3H/HeJ	MGP_C3HHeJ_G0024998	protein coding gene	Chr19:56220065-56222552 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025681	protein coding gene	Chr19:58469178-58473439 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023093	protein coding gene	Chr19:53193068-53195550 (+)
CAST/EiJ	MGP_CASTEiJ_G0024463	protein coding gene	Chr19:56251753-56254233 (+)
CBA/J	MGP_CBAJ_G0024978	protein coding gene	Chr19:61371104-61373591 (+)
DBA/2J	MGP_DBA2J_G0025110	protein coding gene	Chr19:54056530-54059017 (+)
FVB/NJ	MGP_FVBNJ_G0025071	protein coding gene	Chr19:53761416-53763904 (+)
LP/J	MGP_LPJ_G0025196	protein coding gene	Chr19:56954429-56956916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025104	protein coding gene	Chr19:60636200-60638686 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025739	protein coding gene	Chr19:56191427-56193917 (+)
PWK/PhJ	MGP_PWKPhJ_G0024211	protein coding gene	Chr19:54023993-54026471 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024014	protein coding gene	Chr19:54871429-54873908 (+)
WSB/EiJ	MGP_WSBEiJ_G0024533	protein coding gene	Chr19:56329183-56333219 (+)

Human Ortholog

ADRB1, adrenoceptor beta 1

Vertebrate Orthologs

9

Human Ortholog

ADRB1, adrenoceptor beta 1
Orthology source: HomoloGene, HGNC
Synonyms

ADRB1R, B1AR, BETA1AR, RHR
Links

HGNC:285

NCBI Gene ID: 153

neXtProt AC: NX_P08588

UniProt: P08588
Chr Location

10q25.3; chr10:114044047-114046908 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20171
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish
HCOP

human homology predictions: ADRB1
Protein SuperFamily

beta adrenergic receptor
Gene Tree

Adrb1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
34 phenotypes from multigenic genotypes
68 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.

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All GO Annotations

94
GO References

19

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

65
Tissues

59
cDNA Data

13
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adrb1

ZFIN adrb1

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Adrb1 interacts with 164 markers (Mir1b, Mir7-2, Mir7b, ...) View All

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS29919.1
UniGene

46797

Ensembl

ENSMUSG00000035283 (Evidence)
NCBI Gene

11554

			Length	Strain/Species	Flank
genomic	11554	NCBI Gene Model \| MGI Sequence Detail	2491	C57BL/6J	± kb
transcript	NM_007419	RefSeq \| MGI Sequence Detail	2491	C57BL/6
polypeptide	P34971	UniProt \| EBI \| MGI Sequence Detail	466	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001192 beta-1 adrenergic receptor

(term hierarchy)
InterPro Domains

IPR002233 Adrenoceptor family

IPR000507 Beta 1 adrenoceptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 22

Genomic 5

cDNA 14

Primer pair 3

Microarray probesets 3

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MGD-MRK-1143, MGD-MRK-1146

Summaries

All 166

Developmental Gene Expression 11

Diseases 1

Gene Ontology 19

Phenotypes 68
Earliest

J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
Latest

J:260521 Masand R, et al., Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018 Mar 6;27(3):616-629.e4

TSS for Adrb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157208	Chr19:56722087-56722094 (+)	-281 bp
Tssr157209	Chr19:56722110-56722128 (+)	-253 bp
Tssr157210	Chr19:56722140-56722153 (+)	-225 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13