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Adrb1
Gene Detail
Symbol

Name
ID
Adrb1
adrenergic receptor, beta 1
MGI:87937
Synonyms
Adrb-1, beta 1-AR
Feature Type
protein coding gene
Genetic Map
Chromosome 19
51.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr19:56722372-56724862 bp, + strand
From NCBI annotation of GRCm38

  2491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb1

Human
homologs
Human Homolog ADRB1, adrenoceptor beta 1
NCBI Gene ID 153
neXtProt AC  NX_P08588
Human Synonyms  ADRB1R, B1AR, BETA1AR, RHR
Human Chr (Location)  10q25.3; chr10:114044047-114046908 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADRB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Adrb1 interacts with 164 markers (Mir1b, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (9 records)
Data Summary: Results (58)    Tissues (55)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 58
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(5) cDNA(13) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035283 (Evidence)
Entrez Gene11554 (Evidence)
UniGene46797
DFCITC1599167
DoTSDT.40154163
NIA Mouse Gene IndexU019602
Consensus CDS ProjectCCDS29919.1
International Mouse Knockout Project StatusAdrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11554 NCBI Gene Model | MGI Sequence Detail 2491 C57BL/6J ±  kb
transcript NM_007419 RefSeq | MGI Sequence Detail 2491 C57BL/6 
polypeptide P34971 UniProt | EBI | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000507 Adrenergic receptor beta 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001192 beta-1 adrenergic receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:212540 Jiang Y, et al., beta1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo. Mol Vis. 2014;20:872-80
All references(114)
Other
accession IDs
MGD-MRK-1143, MGD-MRK-1146

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory