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Adrb1
Gene Detail
 Symbol
Name
ID
Adrb1
adrenergic receptor, beta 1
MGI:87937
Synonyms Adrb-1, beta 1-AR
Feature Type protein coding gene
Genetic Map
Chromosome 19
51.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr19:56722372-56724862 bp, + strand
From NCBI annotation of GRCm38

  2491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb1

Human
homologs
Human Homolog ADRB1, adrenoceptor beta 1
NCBI Gene ID 153
neXtProt AC  NX_P08588
Human Synonyms  ADRB1R, B1AR, BETA1AR, RHR
Human Chr (Location)  10q25.3; chr10:114044047-114046908 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADRB1
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component cytoplasm, early endosome, ...
Function adrenergic receptor activity, alpha-2A adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (61)    Tissues (57)    Images (1)
Theiler Stages: 3, 4, 5, 12, 14, 18, 21, 23, 25, 28
Assay TypeResults
RT-PCR 61
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(5) cDNA(13) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035283 (Evidence)
Entrez Gene11554 (Evidence)
UniGene46797
DFCITC1599167
DoTSDT.40154163
NIA Mouse Gene IndexU019602
Consensus CDS ProjectCCDS29919.1
International Mouse Knockout Project StatusAdrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11554 NCBI Gene Model | MGI Sequence Detail 2491 C57BL/6J ±  kb
transcript NM_007419 RefSeq | MGI Sequence Detail 2491 C57BL/6 
polypeptide P34971 UniProt | EBI | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000507 Adrenergic receptor beta 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001192 beta-1 adrenergic receptor
Graphical View of Protein Domain Structure
References (Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:204379 Jiang Y, et al., beta2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. PLoS One. 2013;8(7):e70555
All references(113)
Other
accession IDs
MGD-MRK-1143, MGD-MRK-1146

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory