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Adrb1 Gene Detail
Summary
  • Symbol
    Adrb1
  • Name
    adrenergic receptor, beta 1
  • Synonyms
    Adrb-1, beta 1-AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87937
    NCBI Gene: 11554
  • Gene Overview
    MyGene.info: ADRB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:56722372-56724862 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2491 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 51.96 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADRB1, adrenoceptor beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRB1R, B1AR, BETA1AR, RHR
  • Links
    NCBI Gene ID: 153
    neXtProt AC: NX_P08588
    UniProt: P08588

  • Chr Location
    10q25.3; chr10:114044047-114046908 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for targeted mutations that inactivate the gene die prenatally, with the penetrance of lethality showing strain dependence. Surviving knockouts appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11554 NCBI Gene Model | MGI Sequence Detail 2491 C57BL/6J ±  kb
    transcript NM_007419 RefSeq | MGI Sequence Detail 2491 C57BL/6  
    polypeptide P34971 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      13 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 5
      cDNA 14
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1143, MGD-MRK-1146
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 18
      Phenotypes 66
    • Earliest
      J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
    • Latest
      J:260521 Masand R, et al., Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018 Mar 6;27(3):616-629.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory