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Add2
Gene Detail
 Symbol
Name
ID
Add2
adducin 2 (beta)
MGI:87919
Synonyms 2900072M03Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
37.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:86078084-86119555 bp, + strand
From NCBI annotation of GRCm38

  41472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Add2

Human
homologs
Human Homolog ADD2, adducin 2 (beta)
NCBI Gene ID 119
neXtProt AC  NX_P35612
Human Synonyms  ADDB
Human Chr (Location)  2p13.3; chr2:70662084-70768243 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for targeted mutations that inactivate the gene display mild anemia with compensated hemolysis, marked alteration in osmotic fragility, predominant presence of elliptocytes in the blood and increased blood pressure.
 
Human Diseases Modeled Using Mouse Add2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process actin filament bundle assembly, barbed-end actin filament capping, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (173)    Tissues (47)    Images (22)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 173
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030000 (Evidence)
Entrez Gene11519 (Evidence)
DFCITC1577110, TC1584489, TC1642182, TC1654427
DoTSDT.101364124, DT.101375466, DT.101375467, DT.101715945, DT.40139230, DT.528092, DT.94172124
NIA Mouse Gene IndexU007110
Consensus CDS ProjectCCDS20308.1
International Mouse Knockout Project StatusAdd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11519 NCBI Gene Model | MGI Sequence Detail 41472 C57BL/6J ±  kb
transcript NM_001271857 RefSeq | MGI Sequence Detail 8223 C57BL/6 
polypeptide Q9QYB8 UniProt | EBI | MGI Sequence Detail 725 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001303 Class II aldolase/adducin N-terminal
Protein Ontology PR:000003764 beta-adducin
Graphical View of Protein Domain Structure
References (Earliest) J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
(Latest) J:185103 Kodippili GC, et al., Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes. J Biol Chem. 2012 Feb 3;287(6):4129-38
All references(53)
Other
accession IDs
MGD-MRK-1109, MGI:1920220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory