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Add2 Gene Detail
Summary
  • Symbol
    Add2
  • Name
    adducin 2 (beta)
  • Synonyms
    2900072M03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87919
    NCBI Gene: 11519
  • Gene Overview
    MyGene.info: ADD2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86028681-86124409 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.55 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87919
protein coding gene Chr6:86028681-86124409 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030970
protein coding gene Chr6:87282228-87384282 (+)
A/J MGP_AJ_G0030936
protein coding gene Chr6:83921808-84019110 (+)
AKR/J MGP_AKRJ_G0030867
protein coding gene Chr6:86354320-86450001 (+)
BALB/cJ MGP_BALBcJ_G0030949
protein coding gene Chr6:83925881-84022194 (+)
C3H/HeJ MGP_C3HHeJ_G0030761
protein coding gene Chr6:98011363-98110506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031406
protein coding gene Chr6:89665718-89765435 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028590
protein coding gene Chr6:82081063-82176237 (+)
CAST/EiJ MGP_CASTEiJ_G0030058
protein coding gene Chr6:86402550-86503491 (+)
CBA/J MGP_CBAJ_G0030633
protein coding gene Chr6:93186314-93287516 (+)
DBA/2J MGP_DBA2J_G0030789
protein coding gene Chr6:83241225-83339619 (+)
FVB/NJ MGP_FVBNJ_G0030742
protein coding gene Chr6:82420226-82513502 (+)
LP/J MGP_LPJ_G0030866
protein coding gene Chr6:87321229-87425717 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030775
protein coding gene Chr6:97340824-97441870 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031433
protein coding gene Chr6:86197990-86298266 (+)
PWK/PhJ MGP_PWKPhJ_G0029773
protein coding gene Chr6:82176255-82271364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029601
protein coding gene Chr6:85030250-85138096 (+)
WSB/EiJ MGP_WSBEiJ_G0030139
protein coding gene Chr6:86641258-86734893 (+)



Homology
more
  • Human Ortholog
    ADD2, adducin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADD2, adducin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADDB
  • Links
    NCBI Gene ID: 119
    neXtProt AC: NX_P35612
    UniProt: P35612

  • Chr Location
    2p13.3; chr2:70656784-70768243 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1221
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADD2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Add2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display mild anemia with compensated hemolysis, marked alteration in osmotic fragility, predominant presence of elliptocytes in the blood and increased blood pressure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11519 NCBI Gene Model | MGI Sequence Detail 95729 C57BL/6J ±  kb
    transcript NM_001271857 RefSeq | MGI Sequence Detail 8223 C57BL/6  
    polypeptide Q9QYB8 UniProt | EBI | MGI Sequence Detail 725 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1109, MGI:1920220
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
    • Latest
      J:228313 Engmann O, et al., DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun. 2015;6:10099

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory