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Add1
Gene Detail
 Symbol
Name
ID
Add1
adducin 1 (alpha)
MGI:87918
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:34573664-34632308 bp, + strand
From VEGA annotation of GRCm38

  58645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Add1

Human
homologs
Human Homolog ADD1, adducin 1 (alpha)
NCBI Gene ID 118
neXtProt AC  NX_P35611
Human Synonyms  ADDA
Human Chr (Location)  4p16.3; chr4:2843727-2930076 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADD1
Alleles
and
phenotypes
All alleles(641) : Gene trapped(639) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted gene deletion leads to reduced growth and compensated hemolytic anemia. RBCs are osmotically fragile, dehydrated, and spherocytic with severe loss of membrane surface area and reduced MCV. ~50% of homozygotes develop lethal hydrocephaly with dilation of the lateral, 3rd, and 4th ventricles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin filament bundle assembly, barbed-end actin filament capping, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (3)    Images (1)
Theiler Stages: 25, 26, 28
Assay TypeResults
Northern blot 6
cDNA source data(311)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(314) cDNA(312) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023097 (Evidence)
Ensembl Gene ModelENSMUSG00000029106 (Evidence)
Entrez Gene11518 (Evidence)
UniGene289106
DFCITC1572146, TC1584400, TC1600717, TC1609311
DoTSDT.101178210, DT.110643348, DT.110643366, DT.110643394, DT.94373286, DT.94394184, DT.99862613
NIA Mouse Gene IndexU005490
Consensus CDS ProjectCCDS19216.1, CCDS39069.1, CCDS51471.1
International Mouse Knockout Project StatusAdd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023097 VEGA Gene Model | MGI Sequence Detail 58645 C57BL/6J ±  kb
transcript OTTMUST00000055850 VEGA | MGI Sequence Detail 3761 Not Applicable 
polypeptide OTTMUSP00000026789 VEGA | MGI Sequence Detail 735 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(34) UniProt(9)
Polymorphisms RFLP(2) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001303 Class II aldolase/adducin N-terminal
Protein Ontology PR:000003763 alpha-adducin
References (Earliest) J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(47)
Other
accession IDs
MGD-MRK-1108, MGI:2140823

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory