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Add1
Gene Detail
Symbol

Name
ID
Add1
adducin 1 (alpha)
MGI:87918
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:34573664-34632308 bp, + strand
From VEGA annotation of GRCm38

  58645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADD1
Gene Tree: Add1

Human
homologs
ADD1, adducin 1 (alpha)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 118
neXtProt AC: NX_P35611

Human Synonyms: ADDA

Human Chr (Location): 4p16.3; chr4:2843727-2930076 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(648) : Chemically induced (ENU)(1) Gene trapped(639) Radiation induced(6) Targeted(2)
Genomic Mutations involving Add1 (7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Targeted gene deletion leads to reduced growth and compensated hemolytic anemia. RBCs are osmotically fragile, dehydrated, and spherocytic with severe loss of membrane surface area and reduced MCV. ~50% of homozygotes develop lethal hydrocephaly with dilation of the lateral, 3rd, and 4th ventricles.
 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Add1 interacts with 241 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process actin filament bundle assembly, barbed-end actin filament capping, ...
Component cell, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (12)    Tissues (6)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
RT-PCR 6
cDNA source data(311)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase add1 ; ZFIN add1    NEW 
Molecular
reagents
All nucleic(315) cDNA(312) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023097 (Evidence)
Ensembl Gene Model ENSMUSG00000029106 (Evidence)
Entrez Gene 11518 (Evidence)
UniGene 289106
DFCI TC1572146, TC1584400, TC1600717, TC1609311
DoTS DT.101178210, DT.110643348, DT.110643366, DT.110643394, DT.94373286, DT.94394184, DT.99862613
NIA Mouse Gene Index U005490
Consensus CDS Project CCDS19216.1, CCDS39069.1, CCDS51471.1
International Mouse Phenotyping Consortium Status Add1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023097 VEGA Gene Model | MGI Sequence Detail 58645 C57BL/6J ±  kb
transcript OTTMUST00000055850 VEGA | MGI Sequence Detail 3761 Not Applicable 
polypeptide OTTMUSP00000026789 VEGA | MGI Sequence Detail 735 Not Applicable 

For the selected sequences
All sequences(147) RefSeq(34) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001303 Class II aldolase/adducin N-terminal
Protein Ontology PR:000003763 alpha-adducin
References
(Earliest) J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(47)
Other
accession IDs
MGD-MRK-1108, MGI:2140823

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory