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Adcy6
Gene Detail
Symbol

Name
ID
Adcy6
adenylate cyclase 6
MGI:87917
Synonyms
AC6
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.59 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98589994-98607633 bp, - strand
From Ensembl annotation of GRCm38

  17640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADCY6
Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy6

Human
homologs
ADCY6, adenylate cyclase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 112
neXtProt AC: NX_O43306

Human Synonyms: AC6, LCCS8

Human Chr (Location): 12q13.12; chr12:48766192-48789037 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADCY6

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Radiation induced(1) Targeted(5)
Genomic Mutations involving Adcy6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruption of this gene show a reduction in calcium uptake and transport in cardiomyocytes as well as mild functional abnormalities in the left ventricle. Mice homozygous for a conditional allele activated in collecting ducts exhibit decreased urine osmilality.
 
Phenotype Images(2)
Interactions
Adcy6 interacts with 287 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (205)    Tissues (147)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
RT-PCR 6
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adcy6    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022994 (Evidence)
Entrez Gene 11512 (Evidence)
DFCI TC1578050
DoTS DT.101295866, DT.50316788, DT.94164987
NIA Mouse Gene Index U036624
EC 4.6.1.1
Consensus CDS Project CCDS27799.1
International Mouse Phenotyping Consortium Status Adcy6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022994 Ensembl Gene Model | MGI Sequence Detail 17640 C57BL/6J ±  kb
transcript ENSMUST00000096224 Ensembl | MGI Sequence Detail 6017 Not Applicable 
polypeptide ENSMUSP00000093939 Ensembl | MGI Sequence Detail 1168 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(15) UniProt(2)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030672 Adenylate cyclase
InterPro IPR009398 Adenylate cyclase, conserved domain
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
InterPro IPR029787 Nucleotide cyclase
Protein Ontology PR:000003757 adenylate cyclase type 6
References
(Earliest) J:1747 Yoshimura M, et al., Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6716-20
(Latest) J:210708 Lee KL, et al., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar;28(3):1157-65
All references(60)
Other
accession IDs
MGD-MRK-1106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory