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Adcy6
Gene Detail
 Symbol
Name
ID
Adcy6
adenylate cyclase 6
MGI:87917
Synonyms AC6
Feature Type protein coding gene
Genetic Map
Chromosome 15
54.59 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:98589994-98607633 bp, - strand
From Ensembl annotation of GRCm38

  17640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy6

Human
homologs
Human Homolog ADCY6, adenylate cyclase 6
NCBI Gene ID 112
neXtProt AC  NX_O43306
Human Synonyms  AC6
Human Chr (Location)  12q12-q13; chr12:48766192-48789037 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Radiation induced(1) Targeted(5)
Genomic Mutations involving Adcy6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene show a reduction in calcium uptake and transport in cardiomyocytes as well as mild functional abnormalities in the left ventricle. Mice homozygous for a conditional allele activated in collecting ducts exhibit decreased urine osmilality.
 
Interactions
Adcy6 interacts with 288 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component cell projection, cilium, ...
Function adenylate cyclase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (205)    Tissues (147)    Images (33)
Theiler Stages: 19, 22, 23, 24, 28
Assay TypeResults
RNA in situ 199
RT-PCR 6
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022994 (Evidence)
Entrez Gene11512 (Evidence)
DFCITC1578050
DoTSDT.101295866, DT.50316788, DT.94164987
NIA Mouse Gene IndexU036624
EC4.6.1.1
Consensus CDS ProjectCCDS27799.1
International Mouse Knockout Project StatusAdcy6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022994 Ensembl Gene Model | MGI Sequence Detail 17640 C57BL/6J ±  kb
transcript ENSMUST00000096224 Ensembl | MGI Sequence Detail 6017 Not Applicable 
polypeptide ENSMUSP00000093939 Ensembl | MGI Sequence Detail 1168 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(35) UniProt(2)
Polymorphisms SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003757 adenylate cyclase type 6
References (Earliest) J:1747 Yoshimura M, et al., Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6716-20
(Latest) J:210708 Lee KL, et al., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar;28(3):1157-65
All references(56)
Other
accession IDs
MGD-MRK-1106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory