About   Help   FAQ
Adcy6 Gene Detail
Summary
  • Symbol
    Adcy6
  • Name
    adenylate cyclase 6
  • Synonyms
    AC6
  • Feature Type
    protein coding gene
  • IDs
    MGI:87917
    NCBI Gene: 11512
  • Gene Overview
    MyGene.info: ADCY6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:98589973-98610076 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20104 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.59 cM, cytoband F
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADCY6, adenylate cyclase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADCY6, adenylate cyclase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AC6, LCCS8
  • Links
    NCBI Gene ID: 112
    neXtProt AC: NX_O43306
    UniProt: O43306

  • Chr Location
    12q13.12; chr12:48766191-48789096 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene show a reduction in calcium uptake and transport in cardiomyocytes as well as mild functional abnormalities in the left ventricle. Mice homozygous for a conditional allele activated in collecting ducts exhibit decreased urine osmilality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022994 Ensembl Gene Model | MGI Sequence Detail 20104 C57BL/6J ±  kb
    transcript ENSMUST00000096224 Ensembl | MGI Sequence Detail 6038 Not Applicable  
    polypeptide ENSMUSP00000093939 Ensembl | MGI Sequence Detail 1168 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      101 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR030672 Adenylate cyclase
      IPR009398 Adenylate cyclase, conserved domain
      IPR032628 Adenylate cyclase, N-terminal
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR029787 Nucleotide cyclase
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1106
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 10
      Phenotypes 42
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:248053 Gao MH, et al., Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained beta-adrenergic stimulation. PLoS One. 2017;12(8):e0181282

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory