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Ada
Gene Detail
Symbol

Name
ID
Ada
adenosine deaminase
MGI:87916
Feature Type
protein coding gene
Genetic Map
Chromosome 2
84.44 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(53)
Sequence Map
Chr2:163726584-163750239 bp, - strand
From VEGA annotation of GRCm38

  23656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenosine deaminase
Gene Tree: Ada

Human
homologs
Human Homolog ADA, adenosine deaminase
NCBI Gene ID 100
neXtProt AC  NX_P00813
Human Chr (Location)  20q13.12; chr20:44619519-44651735 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADA
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene die perinatally with defective purine metabolism and severe liver cell degeneration, but lack thymic abnormalities. Replacement of placental ADA can rescue ADA-deficient fetuses, resulting in mice that are T and B-cell deficient, have elevated dATP levels, and immune deficiencies resembling human ADA deficiency.
 
Human Diseases Modeled Using Mouse Ada (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Ada interacts with 49 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process adenosine catabolic process, adenosine metabolic process, ...
Component cell junction, cell surface, ...
Function adenosine deaminase activity, deaminase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (352)    Tissues (146)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 203
RT-PCR 138
RNase protection 4
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) Genomic(33) cDNA(87) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001154 (Evidence)
Ensembl Gene ModelENSMUSG00000017697 (Evidence)
Entrez Gene11486 (Evidence)
UniGene388
DFCITC1578069, TC1763119
DoTSDT.535284, DT.94296256
NIA Mouse Gene IndexU023620
EC3.5.4.4
PDB1A4L, 1A4M, 1ADD, 1FKW, 1FKX, 1UIO, 1UIP, 2ADA, 3MVI, 3MVT, 3T1G, 3KM8
Consensus CDS ProjectCCDS17015.1
International Mouse Knockout Project StatusAda
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001154 VEGA Gene Model | MGI Sequence Detail 23656 C57BL/6J ±  kb
transcript OTTMUST00000002247 VEGA | MGI Sequence Detail 1688 Not Applicable 
polypeptide OTTMUSP00000001096 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(12) : PCR(1) RFLP(11) SNPs within 2kb(466 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006330 Adenosine/adenine deaminase
InterPro IPR006650 Adenosine/AMP deaminase active site
InterPro IPR001365 Adenosine/AMP deaminase domain
Protein Ontology PR:000003707 adenosine deaminase
References
(Earliest) J:7486 Siciliano MJ, et al., Regional assignment of ADA and ITPA to mouse chromosome 2 (C1----ter). A demonstration of the conserved linkage of enzyme and proto-oncogene loci. J Hered. 1984 May-Jun;75(3):175-80
(Latest) J:191331 Carbonaro DA, et al., Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction. Blood. 2012 Nov 1;120(18):3677-87
All references(141)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory