Ada
Gene Detail

Symbol Name ID

Ada adenosine deaminase MGI:87916

Feature Type

protein coding gene

Genetic Map

Chromosome 2

84.44 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(53)

Sequence Map

Chr2:163726584-163750239 bp, - strand From VEGA annotation of GRCm38   23656 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenosine deaminase
Gene Tree: Ada

Human homologs

Human Homolog		ADA, adenosine deaminase
NCBI Gene ID		100
neXtProt AC		NX_P00813
Human Chr (Location)		20q13.12; chr20:43248163-43280376 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADA

Alleles and phenotypes

All alleles(5) : Targeted(4) Other(1)
 

Mice homozygous for targeted mutations that inactivate the gene die perinatally with defective purine metabolism and severe liver cell degeneration, but lack thymic abnormalities. Replacement of placental ADA can rescue ADA-deficient fetuses, resulting in mice that are T and B-cell deficient, have elevated dATP levels, and immune deficiencies resembling human ADA deficiency.

 
Human Diseases Modeled Using Mouse Ada (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (105 annotations)

Process	adenosine catabolic process, adenosine metabolic process, ...
Component	cell junction, cell surface, ...
Function	adenosine deaminase activity, deaminase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (352)    Tissues (146)    Images (20)
Theiler Stages: 11, 15, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	203
RT-PCR	138
RNase protection	4

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(126) Genomic(33) cDNA(88) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000001154 (Evidence)
Ensembl Gene Model	ENSMUSG00000017697 (Evidence)
Entrez Gene	11486 (Evidence)
UniGene	388
DFCI	TC1578069, TC1763119
DoTS	DT.535284, DT.94296256
NIA Mouse Gene Index	U023620
EC	3.5.4.4
PDB	1A4L, 1A4M, 1ADD, 1FKW, 1FKX, 1UIO, 1UIP, 2ADA, 3MVI, 3MVT, 3T1G, 3KM8
Consensus CDS Project	CCDS17015.1
International Mouse Knockout Project Status	Ada

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001154	VEGA Gene Model | MGI Sequence Detail	23656	C57BL/6J
transcript	OTTMUST00000002247	VEGA | MGI Sequence Detail	1688	Not Applicable
polypeptide	OTTMUSP00000001096	VEGA | MGI Sequence Detail	352	Not Applicable

All sequences(46) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(12) : PCR(1) RFLP(11) SNPs(343 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006330	Adenosine/adenine deaminase
InterPro	IPR006650	Adenosine/AMP deaminase active site
InterPro	IPR001365	Adenosine/AMP deaminase domain
Protein Ontology	PR:000003707	adenosine deaminase

References

(Earliest) J:7486 Siciliano MJ, et al., Regional assignment of ADA and ITPA to mouse chromosome 2 (C1----ter). A demonstration of the conserved linkage of enzyme and proto-oncogene loci. J Hered. 1984 May-Jun;75(3):175-80
(Latest) J:191331 Carbonaro DA, et al., Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction. Blood. 2012 Nov 1;120(18):3677-87
All references(140)

Other accession IDs

MGD-MRK-1104