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Acta2
Gene Detail
Symbol

Name
ID
Acta2
actin, alpha 2, smooth muscle, aorta
MGI:87909
Synonyms
0610041G09Rik, Actvs, alphaSMA, a-SMA, SMalphaA
Feature Type
protein coding gene
Genetic Map
Chromosome 19
29.41 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:34241090-34255336 bp, - strand
From Ensembl annotation of GRCm38

  14247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACTA2
Protein SuperFamily: actin
Gene Tree: Acta2

Human
homologs
ACTA2, actin, alpha 2, smooth muscle, aorta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 59
neXtProt AC: NX_P62736

Human Synonyms: AAT6, ACTSA, MYMY5

Human Chr (Location): 10q23.3; chr10:88935074-88991390 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ACTA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired vascular contractility and blood pressure homeostasis, increased blood-retina barrier permeability, and reduced retinal cone and rod function.
 
Interactions
Acta2 interacts with 126 markers (Mir7-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process muscle contraction, regulation of blood pressure, ...
Component actin cytoskeleton, cytoplasm, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (830 records)
Data Summary: Results (642)    Tissues (294)    Images (269)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 374
RNA in situ 225
Western blot 8
RT-PCR 35
cDNA source data(374)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acta2 ; ZFIN acta2    NEW 
Molecular
reagents
All nucleic(389) Genomic(7) cDNA(374) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035783 (Evidence)
Entrez Gene 11475 (Evidence)
UniGene 213025
DFCI TC1573391, TC1593954, TC1612174
DoTS DT.55135100, DT.87075094, DT.97375089, DT.99868907
NIA Mouse Gene Index U038980
Consensus CDS Project CCDS29757.1
International Mouse Phenotyping Consortium Status Acta2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035783 Ensembl Gene Model | MGI Sequence Detail 14247 C57BL/6J ±  kb
transcript ENSMUST00000039631 Ensembl | MGI Sequence Detail 1781 Not Applicable 
polypeptide ENSMUSP00000048218 Ensembl | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin family
Protein Ontology PR:000003675 actin, aortic smooth muscle
References
(Earliest) J:9473 Min BH, et al., Nucleotide sequence of a mouse vascular smooth muscle alpha-actin cDNA. Nucleic Acids Res. 1988 Nov 11;16(21):10374
(Latest) J:222787 Liu C, et al., Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015;6:6934
All references(890)
Other
accession IDs
MGD-MRK-1095, MGI:1915627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory