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Acta2
Gene Detail
 Symbol
Name
ID
Acta2
actin, alpha 2, smooth muscle, aorta
MGI:87909
Synonyms 0610041G09Rik, Actvs, alphaSMA, a-SMA, SMalphaA
Feature Type protein coding gene
Genetic Map
Chromosome 19
29.41 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:34241091-34255336 bp, - strand
From NCBI annotation of GRCm38

  14246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: actin
Gene Tree: Acta2

Human
homologs
Human Homolog ACTA2, actin, alpha 2, smooth muscle, aorta
NCBI Gene ID 59
neXtProt AC  NX_P62736
Human Synonyms  AAT6, ACTSA, MYMY5
Human Chr (Location)  10q23.3; chr10:88935074-88991390 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ACTA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired vascular contractility and blood pressure homeostasis, increased blood-retina barrier permeability, and reduced retinal cone and rod function.
 
Interactions
Acta2 interacts with 127 markers (Mir7-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process muscle contraction, regulation of blood pressure, ...
Component actin cytoskeleton, cytoplasm, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (728 records)
Data Summary: Results (618)    Tissues (283)    Images (258)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 352
RNA in situ 227
Western blot 6
RT-PCR 33
cDNA source data(374)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(388) Genomic(7) cDNA(374) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035783 (Evidence)
Entrez Gene11475 (Evidence)
UniGene213025
DFCITC1573391, TC1593954, TC1612174
DoTSDT.55135100, DT.87075094, DT.97375089, DT.99868907
NIA Mouse Gene IndexU038980
Consensus CDS ProjectCCDS29757.1
International Mouse Knockout Project StatusActa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11475 NCBI Gene Model | MGI Sequence Detail 14246 C57BL/6J ±  kb
transcript NM_007392 RefSeq | MGI Sequence Detail 2572 C57BL/6 
polypeptide P62737 UniProt | EBI | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003675 actin, aortic smooth muscle
Graphical View of Protein Domain Structure
References (Earliest) J:9473 Min BH, et al., Nucleotide sequence of a mouse vascular smooth muscle alpha-actin cDNA. Nucleic Acids Res. 1988 Nov 11;16(21):10374
(Latest) J:210584 van Berlo JH, et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
All references(788)
Other
accession IDs
MGD-MRK-1095, MGI:1915627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory