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Actb Gene Detail
Summary
  • Symbol
    Actb
  • Name
    actin, beta
  • Synonyms
    Actx, A-X actin-like protein, beta-actin, E430023M04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87904
    NCBI Gene: 11461
  • Gene Overview
    MyGene.info: ACTB
Location & Maps
more
  • Sequence Map
    Chr5:142903115-142906754 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3640 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 81.80 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    ACTB, actin beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACTB, actin beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRWS1, PS1TP5BP1
  • Links
    NCBI Gene ID: 60
    neXtProt AC: NX_P60709

  • Chr Location
    7p22.1; chr7:5527148-5530601 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 110648
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;2 macaque, rhesus
  • HCOP
    human homology predictions: ACTB
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human ACTB associations

Human Disease Mouse Models
       Baraitser-Winter Syndrome 1; BRWS1   OMIM: 243310
Dystonia, Juvenile-Onset; DJO   OMIM: 607371
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 12 alleles in 13 genetic backgrounds
    20 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Gene trapped
    23
  • Targeted
    19
  • Transgenic
    1
  • Incidental Mutations
Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035960 VEGA Gene Model | MGI Sequence Detail 3640 C57BL/6J ±  kb
transcript OTTMUST00000092248 VEGA | MGI Sequence Detail 1920 Not Applicable  
polypeptide OTTMUSP00000050934 VEGA | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    12 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    Genomic 4
    cDNA 89
    Primer pair 9
    Other 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1087, MGD-MRK-1096, MGI:2443247, MGI:87910
References
more
  • Summaries
    All 190
    Developmental Gene Expression 71
    Diseases 1
    Gene Ontology 13
    Phenotypes 50
  • Earliest
    J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
  • Latest
    J:233627 Salinas E, et al., Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016 Feb;90(3):1397-413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory