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Actb
Gene Detail
Symbol

Name
ID
Actb
actin, beta
MGI:87904
Synonyms
Actx, A-X actin-like protein, beta-actin, E430023M04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
81.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:142903115-142906754 bp, - strand
From VEGA annotation of GRCm38

  3640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: actin
Gene Tree: Actb

Human
homologs
Human Homolog ACTB, actin, beta
NCBI Gene ID 60
neXtProt AC  NX_P60709
Human Synonyms  BRWS1, PS1TP5BP1
Human Chr (Location)  7p22; chr7:5527148-5530601 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ACTB
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(23) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter.
 
Interactions
Actb interacts with 177 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process ATP-dependent chromatin remodeling, axonogenesis, ...
Component axon, blood microparticle, ...
Function ATP binding, kinesin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (74)    Tissues (27)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
Northern blot 12
RT-PCR 58
cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) Genomic(4) cDNA(88) Primer pair(9) Other(4)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035960 VEGA Gene Model | MGI Sequence Detail 3640 C57BL/6J ±  kb
transcript OTTMUST00000092248 VEGA | MGI Sequence Detail 1920 Not Applicable 
polypeptide OTTMUSP00000050934 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(206) RefSeq(2) UniProt(45)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003676 actin, cytoplasmic 1
References
(Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(185)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1087, MGD-MRK-1096, MGI:2443247, MGI:87910

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory