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Actb
Gene Detail
 Symbol
Name
ID
Actb
actin, beta
MGI:87904
Synonyms Actx, A-X actin-like protein, beta-actin, E430023M04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
81.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:142903115-142906754 bp, - strand
From VEGA annotation of GRCm38

  3640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: actin
Gene Tree: Actb

Human
homologs
Human Homolog ACTB, actin, beta
NCBI Gene ID 60
neXtProt AC  NX_P60709
Human Synonyms  BRWS1, PS1TP5BP1
Human Chr (Location)  7p22; chr7:5527148-5530601 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ACTB
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(23) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter.
 
Interactions
Actb interacts with 177 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process ATP-dependent chromatin remodeling, axonogenesis, ...
Component axon, blood microparticle, ...
Function ATP binding, kinesin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (74)    Tissues (27)    Images (5)
Theiler Stages: 1, 2, 3, 4, 5, 11, 20, 23, 27, 28
Assay TypeResults
RNA in situ 4
Northern blot 12
RT-PCR 58
cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) Genomic(4) cDNA(88) Primer pair(9) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035960 (Evidence)
Ensembl Gene ModelENSMUSG00000029580 (Evidence)
Entrez Gene11461 (Evidence)
DFCITC1573613, TC1595090, TC1730400
DoTSDT.101299055, DT.101365528, DT.101365836, DT.110665022, DT.110665193, DT.87077887, DT.91351086, DT.91601358, DT.94151071, DT.94160630, DT.97360868, DT.97396027, DT.99872807
Consensus CDS ProjectCCDS19833.1
International Mouse Knockout Project StatusActb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035960 VEGA Gene Model | MGI Sequence Detail 3640 C57BL/6J ±  kb
transcript OTTMUST00000092248 VEGA | MGI Sequence Detail 1920 Not Applicable 
polypeptide OTTMUSP00000050934 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(184) RefSeq(2) UniProt(23)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003676 actin, cytoplasmic 1
References (Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:211201 Yao H, et al., SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L816-28
All references(178)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1087, MGD-MRK-1096, MGI:2443247, MGI:87910

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory