Actb
Gene Detail

Symbol Name ID

Actb actin, beta MGI:87904

Synonyms

Actx, A-X actin-like protein, beta-actin, E430023M04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5

81.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:142903115-142906754 bp, - strand From VEGA annotation of GRCm38   3640 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Actb

Human homologs

Human Homolog		ACTB, actin, beta
NCBI Gene ID		60
neXtProt AC		NX_P60709
Human Synonyms		BRWS1, PS1TP5BP1
Human Chr (Location)		7p22; chr7:5566779-5570232 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ACTB

Alleles and phenotypes

All alleles(39) : Targeted(16) Gene trapped(23)
 

Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	axonogenesis
Component	axon, cortical cytoskeleton, ...
Function	ATP binding, kinesin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (78)    Tissues (28)    Images (4)
Theiler Stages: 1, 2, 3, 4, 5, 11, 23, 28

Assay Type	Results
RNA in situ	2
Northern blot	12
RT-PCR	64

cDNA source data(87)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(104) Genomic(4) cDNA(88) Primer pair(9) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035960 (Evidence)
Ensembl Gene Model	ENSMUSG00000029580 (Evidence)
Entrez Gene	11461 (Evidence)
DFCI	TC1573613, TC1595090, TC1730400
DoTS	DT.101299055, DT.101365528, DT.101365836, DT.110665022, DT.110665193, DT.87077887, DT.91351086, DT.91601358, DT.94151071, DT.94160630, DT.97360868, DT.97396027, DT.99872807
Consensus CDS Project	CCDS19833.1
International Mouse Knockout Project Status	Actb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035960	VEGA Gene Model | MGI Sequence Detail	3640	C57BL/6J
transcript	OTTMUST00000092248	VEGA | MGI Sequence Detail	1920	Not Applicable
polypeptide	OTTMUSP00000050934	VEGA | MGI Sequence Detail	375	Not Applicable

All sequences(187) RefSeq(2) UniProt(24)

Polymorphisms

All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020902	Actin/actin-like conserved site
InterPro	IPR004001	Actin, conserved site
InterPro	IPR004000	Actin-like
Protein Ontology	PR:000003676	actin, cytoplasmic 1

References

(Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:193127 Sasaki T, et al., Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20720-5
All references(171)

Other accession IDs

MGD-MRK-1087, MGD-MRK-1096, MGI:2443247, MGI:87910