Chrnd
Gene Detail

Symbol Name ID

Chrnd cholinergic receptor, nicotinic, delta polypeptide MGI:87893

Synonyms

Achr-4, Acrd

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr1:87190652-87200069 bp, + strand From Ensembl annotation of GRCm38   9418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrnd

Human homologs

Human Homolog		CHRND, cholinergic receptor, nicotinic, delta (muscle)
NCBI Gene ID		1144
neXtProt AC		NX_Q07001
Human Synonyms		ACHRD, CMS2A, FCCMS, SCCMS
Human Chr (Location)		2q37.1; chr2:233390870-233401375 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CHRND

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cation transport, ion transmembrane transport, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (51)    Tissues (8)    Images (25)
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	30
Northern blot	9

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(7) cDNA(15) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026251 (Evidence)
Entrez Gene	11447 (Evidence)
UniGene	2811
DFCI	TC1589939, TC1607499
DoTS	DT.481890, DT.97363109
NIA Mouse Gene Index	U000552
Consensus CDS Project	CCDS15129.1
International Mouse Knockout Project Status	Chrnd

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026251	Ensembl Gene Model | MGI Sequence Detail	9418	C57BL/6J
transcript	ENSMUST00000073252	Ensembl | MGI Sequence Detail	2909	Not Applicable
polypeptide	ENSMUSP00000072983	Ensembl | MGI Sequence Detail	520	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005466	acetylcholine receptor subunit delta

References

(Earliest) J:7701 LaPolla RJ, et al., Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor. Proc Natl Acad Sci U S A. 1984 Dec;81(24):7970-4
(Latest) J:184452 Mouslim C, et al., A role for the calmodulin kinase II-related anchoring protein (alphakap) in maintaining the stability of nicotinic acetylcholine receptors. J Neurosci. 2012 Apr 11;32(15):5177-85
All references(77)

Other accession IDs

MGD-MRK-1039, MGD-MRK-1068, MGI:2138724