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Chrnd
Gene Detail
 Symbol
Name
ID
Chrnd
cholinergic receptor, nicotinic, delta polypeptide
MGI:87893
Synonyms Achr-4, Acrd
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:87190652-87200069 bp, + strand
From Ensembl annotation of GRCm38

  9418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrnd

Human
homologs
Human Homolog CHRND, cholinergic receptor, nicotinic, delta (muscle)
NCBI Gene ID 1144
neXtProt AC  NX_Q07001
Human Synonyms  ACHRD, CMS2A, FCCMS, SCCMS
Human Chr (Location)  2q37.1; chr2:232526160-232536665 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CHRND
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Chrnd interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cation transport, ion transmembrane transport, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (51)    Tissues (8)    Images (25)
Theiler Stages: 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 30
Northern blot 9
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(7) cDNA(15) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026251 (Evidence)
Entrez Gene11447 (Evidence)
UniGene2811
DFCITC1589939, TC1607499
DoTSDT.481890, DT.97363109
NIA Mouse Gene IndexU000552
Consensus CDS ProjectCCDS15129.1
International Mouse Knockout Project StatusChrnd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026251 Ensembl Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
transcript ENSMUST00000073252 Ensembl | MGI Sequence Detail 2909 Not Applicable 
polypeptide ENSMUSP00000072983 Ensembl | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005466 acetylcholine receptor subunit delta
References (Earliest) J:7701 LaPolla RJ, et al., Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor. Proc Natl Acad Sci U S A. 1984 Dec;81(24):7970-4
(Latest) J:198597 Gupta S, et al., Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J Biol Chem. 2013 May 3;288(18):12667-79
All references(78)
Other
accession IDs
MGD-MRK-1039, MGD-MRK-1068, MGI:2138724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory