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Chrnb2
Gene Detail
Symbol

Name
ID
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
MGI:87891
Synonyms
Acrb2, Acrb-2, [b]2-nAchR, C030030P04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89746195-89764632 bp, - strand
From VEGA annotation of GRCm38

  18438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:595  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CHRNB2
Gene Tree: Chrnb2

Human
homologs
CHRNB2, cholinergic receptor, nicotinic, beta 2 (neuronal)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1141
neXtProt AC: NX_P17787

Human Synonyms: EFNL3, nAChRB2

Human Chr (Location): 1q21.3; chr1:154567781-154579878 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHRNB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have impaired responses to nicotine, but show improved passive avoidance behavior. With age, mutants show more neurodegeneration and alterations of the visual system, with decreased cortical visual acuity.
 
Human Diseases Modeled in Mice Using Chrnb2 (3)    Mutations Annotated to Human Diseases (2)   
Interactions
Chrnb2 interacts with 311 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (213)    Tissues (192)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
Northern blot 8
RT-PCR 17
cDNA source data(58)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase chrnb2    NEW 
Molecular
reagents
All nucleic(64) cDNA(60) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000052879 (Evidence)
Ensembl Gene Model ENSMUSG00000027950 (Evidence)
Entrez Gene 11444 (Evidence)
UniGene 35088
DFCI TC1580243, TC1605007
DoTS DT.101735197, DT.87047912
NIA Mouse Gene Index U024284
Consensus CDS Project CCDS17515.1
International Mouse Phenotyping Consortium Status Chrnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052879 VEGA Gene Model | MGI Sequence Detail 18438 C57BL/6J ±  kb
transcript OTTMUST00000132331 VEGA | MGI Sequence Detail 3482 Not Applicable 
polypeptide OTTMUSP00000070559 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005463 neuronal acetylcholine receptor subunit beta-2
References
(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:213058 Golding B, et al., Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Neuron. 2014 Mar 5;81(5):1057-69
All references(156)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1064, MGD-MRK-1066, MGI:2442758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory