Chrnb2
Gene Detail

Symbol Name ID

Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) MGI:87891

Synonyms

Acrb2, Acrb-2, [b]2-nAchR, C030030P04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:89753448-89764632 bp, - strand From NCBI annotation of GRCm38   11185 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:595  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrnb2

Human homologs

Human Homolog		CHRNB2, cholinergic receptor, nicotinic, beta 2 (neuronal)
NCBI Gene ID		1141
neXtProt AC		NX_P17787
Human Synonyms		EFNL3, nAChRB2
Human Chr (Location)		1q21.3; chr1:154540257-154552354 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHRNB2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for targeted null mutations have impaired responses to nicotine, but show improved passive avoidance behavior. With age, mutants show more neurodegeneration and alterations of the visual system, with decreased cortical visual acuity.

 

Gene Ontology (GO) classifications

All GO classifications: (95 annotations)

Process	associative learning, B cell activation, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (169)    Tissues (147)    Images (28)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	144
Northern blot	8
RT-PCR	17

cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(61) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000027950 (Evidence)
Entrez Gene	11444 (Evidence)
UniGene	35088
DFCI	TC1580243, TC1605007
DoTS	DT.101735197, DT.87047912
NIA Mouse Gene Index	U024284
Consensus CDS Project	CCDS17515.1
International Mouse Knockout Project Status	Chrnb2

Sequences

Length	Strain/Species
genomic	11444	NCBI Gene Model | MGI Sequence Detail	11185	C57BL/6J
transcript	NM_009602	RefSeq | MGI Sequence Detail	5405	C57BL/6
polypeptide	Q9ERK7	UniProt | EBI | MGI Sequence Detail	501	Not Applicable

All sequences(30) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR027361	Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005463	neuronal acetylcholine receptor subunit beta-2

Graphical View of Protein Domain Structure

References

(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:191172 Poorthuis RB, et al., Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors. Cereb Cortex. 2013 Jan;23(1):148-61
All references(144)

Other accession IDs

MGD-MRK-1064, MGD-MRK-1066, MGI:2442758