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Chrnb2
Gene Detail
 Symbol
Name
ID
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
MGI:87891
Synonyms Acrb2, Acrb-2, [b]2-nAchR, C030030P04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89753448-89764632 bp, - strand
From NCBI annotation of GRCm38

  11185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:595  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Chrnb2

Human
homologs
Human Homolog CHRNB2, cholinergic receptor, nicotinic, beta 2 (neuronal)
NCBI Gene ID 1141
neXtProt AC  NX_P17787
Human Synonyms  EFNL3, nAChRB2
Human Chr (Location)  1q21.3; chr1:154567781-154580026 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHRNB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have impaired responses to nicotine, but show improved passive avoidance behavior. With age, mutants show more neurodegeneration and alterations of the visual system, with decreased cortical visual acuity.
 
Human Diseases Modeled Using Mouse Chrnb2 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Chrnb2 interacts with 311 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process action potential, associative learning, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (213)    Tissues (192)    Images (30)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 188
Northern blot 8
RT-PCR 17
cDNA source data(58)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) cDNA(60) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000027950 (Evidence)
Entrez Gene11444 (Evidence)
UniGene35088
DFCITC1580243, TC1605007
DoTSDT.101735197, DT.87047912
NIA Mouse Gene IndexU024284
Consensus CDS ProjectCCDS17515.1
International Mouse Knockout Project StatusChrnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11444 NCBI Gene Model | MGI Sequence Detail 11185 C57BL/6J ±  kb
transcript NM_009602 RefSeq | MGI Sequence Detail 5405 C57BL/6 
polypeptide Q9ERK7 UniProt | EBI | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005463 neuronal acetylcholine receptor subunit beta-2
Graphical View of Protein Domain Structure
References (Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:213058 Golding B, et al., Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Neuron. 2014 Mar 5;81(5):1057-69
All references(154)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1064, MGD-MRK-1066, MGI:2442758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory