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Chrnb2 Gene Detail
Summary
  • Symbol
    Chrnb2
  • Name
    cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
  • Synonyms
    Acrb2, Acrb-2, [b]2-nAchR, C030030P04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87891
    NCBI Gene: 11444
  • Gene Overview
    MyGene.info: CHRNB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:89746195-89764632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18438 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.19 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CHRNB2, cholinergic receptor nicotinic beta 2 subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHRNB2, cholinergic receptor nicotinic beta 2 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EFNL3, nAChRB2
  • Links
    NCBI Gene ID: 1141
    neXtProt AC: NX_P17787
    UniProt: P17787

  • Chr Location
    1q21.3; chr1:154567781-154580026 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 595
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHRNB2
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Chrnb2 mouse models; 1 with human CHRNB2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 5 alleles in 10 genetic backgrounds
    25 phenotypes from multigenic genotypes
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have impaired responses to nicotine, but show improved passive avoidance behavior. With age, mutants show more neurodegeneration and alterations of the visual system, with decreased cortical visual acuity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000052879 VEGA Gene Model | MGI Sequence Detail 18438 C57BL/6J ±  kb
    transcript OTTMUST00000132331 VEGA | MGI Sequence Detail 3482 Not Applicable  
    polypeptide OTTMUSP00000070559 VEGA | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      92 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR032932 Neuronal acetylcholine receptor subunit beta-2
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 61
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1064, MGD-MRK-1066, MGI:2442758
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 12
      Diseases 4
      Gene Ontology 42
      Phenotypes 124
    • Earliest
      J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
    • Latest
      J:261146 Donvito G, et al., The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-alpha represents a new antinociceptive signaling pathway in mice. Exp Neurol. 2017 Sep;295:194-201

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory