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Symbol
Name
ID
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
MGI:87891
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Urinary incontinence
Depression
Atypical behavior
Attention deficit hyperactivity disorder
Motor stereotypy
Disease(s) Associated with CHRNB2
autosomal dominant nocturnal frontal lobe epilepsy

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
abnormal behavioral response to nicotine
abnormal associative learning
impaired passive avoidance behavior
abnormal habituation to a new environment
abnormal response to new environment
enhanced spatial learning
decreased anxiety-related response
abnormal response to novelty
enhanced coordination
increased locomotor activity
hyperactivity
fragmentation of sleep/wake states
decreased chemically-elicited antinociception
abnormal social investigation
seizures
increased susceptibility to induction of seizure by inducing agent
Availability Mouse Genotype
Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Chrnb2tm1Jpc/Chrnb2tm1Jpc *
Chrnb2tm1.1Cont/Chrnb2+
Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-Chrnb2*V287L)H3Gica/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory