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Chrnb1 Gene Detail
Summary
  • Symbol
    Chrnb1
  • Name
    cholinergic receptor nicotinic beta 1 subunit
  • Synonyms
    Achr-2, AChR beta, Acrb
  • Feature Type
    protein coding gene
  • IDs
    MGI:87890
    NCBI Gene: 11443
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69674862-69686742 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.87 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87890
protein coding gene Chr11:69674862-69686769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018554
protein coding gene Chr11:70262015-70275788 (-)
A/J MGP_AJ_G0018522
protein coding gene Chr11:67605010-67616910 (-)
AKR/J MGP_AKRJ_G0018491
protein coding gene Chr11:69622837-69636194 (-)
BALB/cJ MGP_BALBcJ_G0018494
protein coding gene Chr11:67930213-67942599 (-)
C3H/HeJ MGP_C3HHeJ_G0018307
protein coding gene Chr11:69654897-69667964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018945
protein coding gene Chr11:72385837-72398031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016590
protein coding gene Chr11:64525926-64539033 (-)
CAST/EiJ MGP_CASTEiJ_G0017862
protein coding gene Chr11:69893800-69905606 (-)
CBA/J MGP_CBAJ_G0018280
protein coding gene Chr11:75624586-75641542 (-)
DBA/2J MGP_DBA2J_G0018389
protein coding gene Chr11:67186890-67199198 (-)
FVB/NJ MGP_FVBNJ_G0018379
protein coding gene Chr11:66828863-66840724 (-)
LP/J MGP_LPJ_G0018459
protein coding gene Chr11:70824566-70839668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018402
protein coding gene Chr11:76234422-76247865 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018987
protein coding gene Chr11:69886801-69898679 (-)
PWK/PhJ MGP_PWKPhJ_G0017636
protein coding gene Chr11:67837787-67849847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017426
protein coding gene Chr11:69707724-69719617 (-)
WSB/EiJ MGP_WSBEiJ_G0017916
protein coding gene Chr11:69553654-69565461 (-)



Homology
more
  • Human Ortholog
    CHRNB1, cholinergic receptor nicotinic beta 1 subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNB1, cholinergic receptor nicotinic beta 1 subunit
  • Synonyms
    ACHRB, CHRNB, CMS1D, CMS2A, CMS2C, SCCMS
  • Links
    NCBI Gene ID: 1140
    neXtProt AC: NX_P11230
    UniProt: P11230

  • Chr Location
    17p13.1; chr17:7445061-7457710 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CHRNB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele lack all tyrosine residues in the beta subunit intracellular loop, display reduced and simplified neuromuscular junctions, and show defective acetylcholine receptor clustering and anchoring at synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11443 NCBI Gene Model | MGI Sequence Detail 11881 C57BL/6J ±  kb
transcript NM_009601 RefSeq | MGI Sequence Detail 2128 ZRU/MplStud  
polypeptide P09690 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005462 acetylcholine receptor subunit beta
  • InterPro Domains
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 43
    Genomic 5
    cDNA 32
    Primer pair 3
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1037, MGD-MRK-1063
References
more
  • Summaries
    All 93
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:5098 Dickerman RC, et al., Position of the acatalasemia gene in linkage group V of the mouse. J Hered. 1968 May-Jun;59(3):177-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory