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Chrna5
Gene Detail
Symbol

Name
ID
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
MGI:87889
Synonyms
Acra5, Acra-5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
29.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:54980880-55007779 bp, + strand
From NCBI annotation of GRCm38

  26900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chrna5

Human
homologs
Human Homolog CHRNA5, cholinergic receptor, nicotinic, alpha 5 (neuronal)
NCBI Gene ID 1138
neXtProt AC  NX_P30532
Human Synonyms  LNCR2
Human Chr (Location)  15q24; chr15:78565520-78595269 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are less sensitive to nicotine-induced seizures than wild-type controls and exhibit a significantly shorter latency time to seizure.
 
Interactions
Chrna5 interacts with 167 markers (Mir16-1, Mir17, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (135)    Tissues (55)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 98
RT-PCR 24
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035594 (Evidence)
Entrez Gene110835 (Evidence)
UniGene103778
DFCITC1587574, TC1591022
DoTSDT.102550793, DT.87048649
NIA Mouse Gene IndexU010516
Consensus CDS ProjectCCDS52800.1
International Mouse Knockout Project StatusChrna5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 110835 NCBI Gene Model | MGI Sequence Detail 26900 C57BL/6J ±  kb
transcript NM_176844 RefSeq | MGI Sequence Detail 2738 C57BL/6 
polypeptide Q2MKA5 UniProt | EBI | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005458 neuronal acetylcholine receptor subunit alpha-5
Graphical View of Protein Domain Structure
References
(Earliest) J:11050 Eng CM, et al., Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics. 1991 Feb;9(2):278-82
(Latest) J:209585 Dao DQ, et al., Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. J Neurosci. 2014 Mar 19;34(12):4273-84
All references(67)
Other
accession IDs
MGD-MRK-1058, MGD-MRK-1062

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory