Chrna5
Gene Detail

Symbol Name ID

Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 MGI:87889

Synonyms

Acra5, Acra-5

Feature Type

protein coding gene

Genetic Map

Chromosome 9

29.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:54980880-55007779 bp, + strand From NCBI annotation of GRCm38   26900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrna5

Human homologs

Human Homolog		CHRNA5, cholinergic receptor, nicotinic, alpha 5 (neuronal)
NCBI Gene ID		1138
neXtProt AC		NX_P30532
Human Synonyms		LNCR2
Human Chr (Location)		15q24; chr15:78857862-78887611 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHRNA5

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele are less sensitive to nicotine-induced seizures than wild-type controls and exhibit a significantly shorter latency time to seizure.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	behavioral response to nicotine, ion transport, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (113)    Tissues (31)    Images (34)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	76
RT-PCR	24

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000035594 (Evidence)
Entrez Gene	110835 (Evidence)
UniGene	103778
DFCI	TC1587574, TC1591022
DoTS	DT.102550793, DT.87048649
NIA Mouse Gene Index	U010516
Consensus CDS Project	CCDS52800.1
International Mouse Knockout Project Status	Chrna5

Sequences

Length	Strain/Species
genomic	110835	NCBI Gene Model | MGI Sequence Detail	26900	C57BL/6J
transcript	NM_176844	RefSeq | MGI Sequence Detail	2738	C57BL/6
polypeptide	Q2MKA5	UniProt | EBI | MGI Sequence Detail	467	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005458	neuronal acetylcholine receptor subunit alpha-5

Graphical View of Protein Domain Structure

References

(Earliest) J:11050 Eng CM, et al., Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics. 1991 Feb;9(2):278-82
(Latest) J:190436 Chakrabarty K, et al., Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open. 2012 Aug 15;1(8):693-704
All references(63)

Other accession IDs

MGD-MRK-1058, MGD-MRK-1062