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Chrna5 Gene Detail
Summary
  • Symbol
    Chrna5
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 5
  • Synonyms
    Acra5, Acra-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:87889
    NCBI Gene: 110835
  • Gene Overview
    MyGene.info: CHRNA5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54980880-55007779 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.84 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87889
protein coding gene Chr9:54979820-55009231 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034835
protein coding gene Chr9:54051935-54087182 (+)
A/J MGP_AJ_G0034816
protein coding gene Chr9:52319930-52347397 (+)
AKR/J MGP_AKRJ_G0034745
protein coding gene Chr9:53513583-53545545 (+)
BALB/cJ MGP_BALBcJ_G0034808
protein coding gene Chr9:52100541-52127816 (+)
C3H/HeJ MGP_C3HHeJ_G0034518
protein coding gene Chr9:53978899-54005564 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035327
protein coding gene Chr9:55560615-55587674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032239
protein coding gene Chr9:51734970-51762250 (+)
CAST/EiJ MGP_CASTEiJ_G0033840
protein coding gene Chr9:54001934-54028593 (+)
CBA/J MGP_CBAJ_G0034489
protein coding gene Chr9:57496686-57526634 (+)
DBA/2J MGP_DBA2J_G0034648
protein coding gene Chr9:52213718-52240556 (+)
FVB/NJ MGP_FVBNJ_G0034590
protein coding gene Chr9:51417943-51445285 (+)
LP/J MGP_LPJ_G0034731
protein coding gene Chr9:54362540-54390772 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034633
protein coding gene Chr9:59013734-59041497 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035349
protein coding gene Chr9:53535189-53563077 (+)
PWK/PhJ MGP_PWKPhJ_G0033544
protein coding gene Chr9:52195744-52223285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033379
protein coding gene Chr9:53789358-53825493 (+)
WSB/EiJ MGP_WSBEiJ_G0033952
protein coding gene Chr9:53496821-53528674 (+)



Homology
more
  • Human Ortholog
    CHRNA5, cholinergic receptor nicotinic alpha 5 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNA5, cholinergic receptor nicotinic alpha 5 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LNCR2
  • Links
    NCBI Gene ID: 1138
    neXtProt AC: NX_P30532
    UniProt: P30532

  • Chr Location
    15q25.1; chr15:78565520-78595269 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55485
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHRNA5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are less sensitive to nicotine-induced seizures than wild-type controls and exhibit a significantly shorter latency time to seizure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035594 Ensembl Gene Model | MGI Sequence Detail 26900 C57BL/6J ±  kb
transcript ENSMUST00000213960 Ensembl | MGI Sequence Detail 1737 Not Applicable  
polypeptide ENSMUSP00000150942 Ensembl | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005458 neuronal acetylcholine receptor subunit alpha-5
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 22
    cDNA 18
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-1058, MGD-MRK-1062
References
more
  • Summaries
    All 74
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:11050 Eng CM, et al., Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics. 1991 Feb;9(2):278-82
  • Latest
    J:264332 Morton G, et al., Chrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposure. J Neurosci. 2018 Jun 28;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory